Skip to main content
SpringerLink
Log in

Antimikrobielle Therapie

  • Chapter
Intensivtherapie bei Sepsis und Multiorganversagen

  • 48 Accesses

Zusammenfassung

Nach der Definition von Schottmüller aus dem Jahr 1914 ist die Sepsis ein Krankheitsbild, welches entsteht, wenn Infektionserreger aus einem lokalen Infektionsherd nach Durchbrechen der Abwehrmechanismen ständig oder intermittierend in die Blutbahn eingeschwemmt werden, zu systemischen Krankheitszeichen Anlaß geben und darüber hinaus u. U. weitere Infektionsherde ausbilden. Diese Definition ist auch von der Konsensuskonferenz 1992 [2] aufgenommen worden, die für die Definition der Sepsis neben den Zeichen des SIRS einen nachgewiesenen Infektionserreger fordert.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Abele-Horn M, Kopp A, Sternberg U et al. (1996) A randomized study comparing fluconazol with amphotericin B/5-flucytosine for the treatment of systemic Candida infections in intensive care patients. Infection 24: 426 - 432

    Article  PubMed  CAS  Google Scholar 

  2. Anonymous (1992) American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for use of innovative therapies in sepsis. Grit Care Med 20: 864 - 874

    Article  Google Scholar 

  3. Baquero F (1996) Trends in antibiotic resistance of respiratory pathogens: an analysis and commentary on a collaborative surveillance study. J Antimicrob Chemother 38 (Suppl A): 117 - 132

    Article  PubMed  CAS  Google Scholar 

  4. Cohen J, McConnel JS (1986) Release of endotoxin from bacteria exposed to ciprofloxacin and its prevention with polymyxin B. Eur J Clin Microbiol 5: 13 - 17

    Article  PubMed  CAS  Google Scholar 

  5. Crosby H, Bion JF, Penn CW, Elliott TSJ (1994) Antibiotic-induced release of endotoxin from bacteria in vitro. J Med Microbiol 40: 23 - 30

    Article  PubMed  CAS  Google Scholar 

  6. DIN 58940-1 (1995) Beuth-Verlag, Berlin

    Google Scholar 

  7. Ellner PD, Neu HC (1981) The inhibitory quotient. JAMA 246: 1575 - 1578

    Google Scholar 

  8. Eng RHK, Smith SM, Fan-Harvard P, Ogbara T (1993) Effect of antibiotics on endotoxin release from gramnegative bacteria. Diagn Microbiol Infect Dis 16: 185 - 189

    Article  PubMed  CAS  Google Scholar 

  9. Gelfand JA, Elin RJ, Berry FW (1976) Endotoxemia associated with the Jarisch-Herxheimer reaction. N Engl J Med 295: 211 - 213

    Article  PubMed  CAS  Google Scholar 

  10. Holzheimer RG, Hirte JF, Reith B et al. (1996) Different endotoxin release and Il-6 plasma levels after antibiotic administration in surgical intensive care patients. J Endotox Res 3: 261 - 267

    CAS  Google Scholar 

  11. Hurley JC (1995) Antibiotic-induced release of Endotoxin, a therapeutic paradox. Drug Safety 12: 183 - 195

    Article  PubMed  CAS  Google Scholar 

  12. Jackson JJ, Kropp H (1992) 13-Lactam antibiotic-induced release of free endotoxin: in vitro comparison of penicillin-binding protein (PBP) 2-specific imipenem and PBP 3-specific ceftazidime. J Infect Dis 165: 1033 - 1041

    Google Scholar 

  13. Jones RN, Pfaller MA, Marshall SA, Hollis RJ, Wilke WW (1997) Antimicrobial activity against 270 nosocomial blood stream infection isolates caused by non-enteric gramnegative bacilli: Occurrence of resistance, molecular epidemiology, and screening for metallo-enzymes. Diagn Microbiol Infect Dis 29: 187-192

    Google Scholar 

  14. Kresken M, Hafner D (1996) Prävalenz der Antibiotikaresistenz bei klinisch wichtigen Infektionserregern in Mitteleuropa, 3. Aufl. Eigenverlag

    Google Scholar 

  15. Norrby SR, Finch RG, Glauser M, and a European Study Group (1993) Monotherapy in serious hospital-acquired infections: a clinical trial of ceftazidime vs. imipenem/cilastatin. J Antimicrob Chemother 31: 927 - 937

    Article  Google Scholar 

  16. Prins JM, van Agtmael MA, Kuijper ED, Deventer SJH, Speelmann P (1995) Antibiotic-induced endotoxin release in patients with gramnegative urosepsis: a double-blind study comparing imipenem and ceftazidime. J Infect Dis 172: 886 - 891

    Article  PubMed  CAS  Google Scholar 

  17. Reinert, RR, Queck A, Kaufhold A, Kresken M, Lütticken R (1995) Antimicrobial resistance and type distribution of Streptococcus pneumoniae isolates causing systemic infections in Germany, 1992-1994. Clin Infect Dis 21: 1398 - 1401

    Article  PubMed  CAS  Google Scholar 

  18. Rex JH, Bennett JE, Sugar AM et al. (1994) A randomized trial comparing fluconacole with amphothericin B for the treatment of candidemia in patients without neutropenia. N Engl J Med 331: 1325 - 1331

    Article  PubMed  CAS  Google Scholar 

  19. Rosenthal EJK (1986) Septikämie-Erreger 1983-1985. Dtsch Med Wochenschr 111: 1874 - 1880

    Article  PubMed  CAS  Google Scholar 

  20. Rosenthal EJK (1993) Epidemiologie von Septikämie-Erregern. Dtsch Med Wochenschr 118: 1269 - 1275

    Article  PubMed  CAS  Google Scholar 

  21. Sandven P, Hoiby EA (1981) The importance of blood volume cultured on detection of Bacteraemia. Acta Pathol Microbiol Scand Sec B 89: 149 - 152

    CAS  Google Scholar 

  22. Simon C, Stille W (1997) Antibiotikatherapie in Klinik und Praxis. Schattauer, Stuttgart New York

    Google Scholar 

  23. Tauchnitz C, Handrick W (1989) Rationelle antimikrobielle Chemotherapie. J.A. Barth, Leipzig

    Google Scholar 

  24. Washington JA (1975) Blood cultures: Principles and techniques. Mayo Clin Proc 50: 91 - 98

    PubMed  Google Scholar 

Download references

Authors
  1. A. C. Rodloff
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Städt. Krankenhaus Hildesheim Lehrkrankenhaus, Medizinischen Hochschule Hannover, Weinberg 1, 31134, Hildesheim, Deutschland

    Hans-Peter Schuster

  2. Klinikum Kröllwitz/Innere Medizin II, Martin-Luther-Universität, Ernst-Grube-Str. 40, 06097, Halle /Saale, Deutschland

    Karl Werdan

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Rodloff, A.C. (2000). Antimikrobielle Therapie. In: Schuster, HP., Werdan, K. (eds) Intensivtherapie bei Sepsis und Multiorganversagen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07962-1_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-07962-1_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-07963-8

  • Online ISBN: 978-3-662-07962-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation