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Mukosales, gastrointestinales Immunsystem (GIS)

  • Chapter
Immunsystem und Infektiologie

Part of the book series: Handbuch der Molekularen Medizin ((HDBMOLEK,volume 4))

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Zusammenfassung

Die gastrointestinale Mukosa weist die enorme Oberfläche von etwa 100–400 m2 auf. Aufgrund der Vielzahl von verschiedenenen Keimen und Antigenen im Darmlumen muß die intestinale Mukosa wesentliche Schrankenfunktionen erfüllen. Sie stellt somit eine der wichtigsten Körperoberflächen dar. Das gastrointestinale Immunsystem (GALT, gut associated lymphoid tissue) übt an dieser Nahtstelle zwischen Körperinnerem und Umgebung eine zentrale Funktion aus. Ganz verschiedene Reaktionen sind nach Einern Antigenkontakt in diesem hochspezialisierten System möglich. Die Induktion einer lokalen oder systemischen Immunantwort, aber auch die Initiation einer systemischen Toleranz können die Folge eines Antigenkontakts mit dem Darm-assoziierten Immunsystem sein.

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Authors
  1. Georg Köhne
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  2. Thomas Schneider
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  3. Martin Zeitz
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  1. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Str. 10, D-13122, Berlin-Buch, Deutschland

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Köhne, G., Schneider, T., Zeitz, M. (1999). Mukosales, gastrointestinales Immunsystem (GIS). In: Ganten, D., Ruckpaul, K. (eds) Immunsystem und Infektiologie. Handbuch der Molekularen Medizin, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07865-5_4

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  • DOI: https://doi.org/10.1007/978-3-662-07865-5_4

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