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Protein-C-Mangelerkrankungen: Pathophysiologie, Diagnostik, Klinik und Therapie

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Hämostaseologie

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Zusammenfassung

Als Protein-C-Mangelpatienten werden prinzipiell Individuen bezeichnet, bei denen Protein-C-Antigen- und/oder Protein-C-Aktivitätswerte unterhalb des Normbereiches gemessen werden, nachdem andere Ursachen einer Protein-C-Verminde-rung, wie Lebererkrankung oder orale Antikoa-gulanzientherapie, ausgeschlossen wurden. Aus einer Studie an Überträgern, also genetisch determinierten Protein-C-Mangelpatienten, ist bekannt, daß die Werte der meisten Protein-C-Mangelpatienten zwischen 35 und 65% liegen. Einzelne Patienten weisen jedoch nach oben und unten stark abweichende Werte auf. Der Bereich der Protein-C-Aktivitäts- und Antigenwerte bei Protein-C-Mangelpatienten vom Typ I betrug 18–88,5%. Daraus kann gefolgert werden, daß einzelne, genetisch determinierte, heterozygote Mangelpatienten durch die Protein-C-Messung allein nicht von normalen Individuen unterschieden werden können.

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Authors
  1. I. Pabinger-Fasching
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Editors and Affiliations

  1. Kerckhoff-Klinik, Abteilung Hämostaseologie und Transfusionsmedizin, Max-Planck-Institut für physiologische und klinische Forschung, Sprudelhof 11, D-61231, Bad Nauheim, Deutschland

    Gert Müller-Berghaus  & Bernd Pötzsch  & 

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© 1999 Springer-Verlag Berlin Heidelberg

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Pabinger-Fasching, I. (1999). Protein-C-Mangelerkrankungen: Pathophysiologie, Diagnostik, Klinik und Therapie. In: Müller-Berghaus, G., Pötzsch, B. (eds) Hämostaseologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07673-6_40

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  • DOI: https://doi.org/10.1007/978-3-662-07673-6_40

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-07674-3

  • Online ISBN: 978-3-662-07673-6

  • eBook Packages: Springer Book Archive

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