Abstract
The dilator effect of Ca2+ antagonists on coronary arteries and on the peripheral vascular bed has been known for a long time. Marked coronary dilatation has been reported for diltiazem and nifedipine; this effect is less pronounced with verapamil. Rafflenbeul and Lichtlen have reported only recently (1982) a 29% increase in the calibre of some coronary stenoses after sublingual nifedipine. The same stenoses showed a 33% dilatation after sublingual nitroglycerin. In addition, the authors found that nifedipine and nitroglycerin had an additive effect, enlarging the calibre of coronary stenoses by 48%. This study was to find out whether the calibre of coronary arteries and coronary stenoses is affected by intravenous gallopamil, and how the haemodynamics respond.
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Rafflenbeul W, Lichtlen PR (1982) Release of residual vascular tone in coronary artery stenoses with Nifedipine and Nitroglycerine. Circulation 66:11–81 [Abstr]
Rafflenbeul W, Heim R, Dzuiba M, Henkel B, Lichtlen P (1976) Morphometric analysis of coronary arteries. In: Lichtlen PR (ed) Coronary angiography and angina pectoris. Thieme, Stuttgart, p 255
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© 1984 Springer-Verlag Berlin Heidelberg
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Sebening, H., Sauer, E. (1984). Effect of Gallopamil on Coronary Arteries and Haemodynamics. In: Kaltenbach, M., Hopf, R. (eds) Gallopamil. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07364-3_12
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DOI: https://doi.org/10.1007/978-3-662-07364-3_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-13737-5
Online ISBN: 978-3-662-07364-3
eBook Packages: Springer Book Archive