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Regulation of C.elegans Life Span by Insulin-Like Signaling

  • Gary Ruvkun
Part of the Research and Perspectives in Endocrine Interactions book series (RPEI)

Abstract

An insulin signaling pathway couples feeding and nutritional status in mammals to the tempo and mode of metabolism in most tissues of the animal (Kahn 1994; Kahn and Weir 1994). Insulin secretion by the pancreas is regulated by nutritional and autonomic neural inputs, and this endocrine signal of metabolic status is detected by target tissues to regulate the activities of metabolic enzymes that synthesize or break down glucose, amino acids, fat, etc. We have shown that an insulin-like signaling pathway regulates longevity and metabolism in C. elegans (Kimura et al. 1997). This regulation may be mechanistically related to the longevity increase caused by caloric restriction in mammals. Our genetic analysis has also revealed outputs of C. elegans insulin -like signaling. We identified human homologs of many of these components in genome databases; many of these homologs have now been shown to transduce insulin and insulin-like signaling in humans.

Keywords

Caenorhabditis Elegans Reproductive Life Span PIP3 Signal Insulin Superfamily Insulin Response Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Gary Ruvkun

There are no affiliations available

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