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Opiatagonist-Antagonisten: Spezielle Pharmakologie

  • K. A. Lehmann

Zusammenfassung

Unter den synthetischen Morphinderivaten mit einem Dreiringsystem, den Benzomorphanen, spielt lediglich das Phenazocin eine gewisse Rolle als Opioidanalgetikum mit rein agonistischer Wirkung. Phenazocin ist etwa 3mal stärker wirksam als Morphin und kann oral, sublingual sowie parenteral appliziert werden.

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Literatur

  1. 1.
    Abboud TK, Moore M, Zhu J, Murakawa K, Minehart M, Longhitano M, Terrasi J, Klepper ID, Choi Y, Kimball S, Chu G (1987) Epidural butorphanol or morphine for the relief of post-cesarean section pain: ventilatory responses to carbon dioxide. Anesth Analg 66: 887–893PubMedGoogle Scholar
  2. 2.
    Adriaensen H, Mattelaer B, Vanmeenen h (1985) A long-term open, clinical and pharmacokinetic assessment of sublingual buprenorphine in patients suffering from chronic pain. Acta Anaesthesiol Belg 36: 33–40Google Scholar
  3. 3.
    Alderman EL, Barry WH, Graham AF, Harrison DC (1972) Hemodynamic effects of morphine and pentazocine differ in cardiac patients. N Engl J Med 287: 623–627PubMedCrossRefGoogle Scholar
  4. 4.
    Alon E, Krayer S, Hossli G (1984) Analgesie und Nebenwirkungen von Nalbuphin ( Nubain) im Vergleich zu Morphin nach Hysterektomie. Anaesthesist 33: 360–362Google Scholar
  5. 5.
    Bahar M, Rosen M, Vickers MD (1985) Self-administered nalbuphine, morphine and pethidine. Comparison, by intravenous route, following cholecystectomy. Anaesthesia 40: 529–532Google Scholar
  6. 6.
    Bailey PL, Clark NJ, Pace NL, Stanley TH, East KA, van Vreeswijk H, van de Pol P, Clissold MA (1987) Antagonism of postoperative opioid-induced respiratory depression: nalbuphine versus naloxone. Anesth Analg 66: 1109–1114PubMedGoogle Scholar
  7. 7.
    Beaver WT, Wallenstein SL, Houde RW, Rogers A (1969) A comparison of the analgesic effects of profadol and morphine in patients with cancer. Clin Pharmacol Ther 10: 314319Google Scholar
  8. 8.
    Beaver WT, Feise GA, Robb D (1981) Analgesic effect of intramuscular and oral nalbuphine in postoperative pain. Clin Pharmacol Ther 29: 174–180PubMedCrossRefGoogle Scholar
  9. 9.
    Bechstein WO, Mehler D, Kirchner E (1984) Akute respiratorische Insuffizienz nach intravenöser Buprenorphin-Gabe. Anästh Intensivmed 25: 449–451Google Scholar
  10. 10.
    Bilsback P, Rolly G, Tampbulon 0 (1985) Efficacy of the extradural administration of lofentanil, buprenorphine or saline in the management of postoperative pain. A double-blind study. Br J Anaesth 57: 943–948Google Scholar
  11. 11.
    Boldt J, Kling D, von Bormann B, Knoblauch K, Görlach G, Hempelmann G (1987) Meptazinol, ein neuartiges Analgetikum. Hämodynamische und respiratorische Effekte. Anaesthesist 36: 622–628Google Scholar
  12. 12.
    Bowdle TA, Greichen SL, Bjustrom RL, Schone RB (1987) Butorphanol improves CO2response and ventilation after fentanyl anesthesia. Anesth Analg 517–522Google Scholar
  13. 13.
    Brewster D, Humphrey HJ, McCleavy MA (1981) The systemic bioavailability of buprenorphine by various routes of administration. J Pharm Pharmacol 35: 500–506CrossRefGoogle Scholar
  14. 14.
    Brewster D, Humphrey HJ, McLeavy MA (1981) Bilary excretion, metabolism and enterohepatic circulation of buprenorphine. Xenobiotica 11: 189–196PubMedCrossRefGoogle Scholar
  15. 15.
    Brogden RN, Speight TM, Avery GS (1973) Pentazocine: a review of its pharmacological properties, therapeutic efficacy and dependence liability. Drugs 5: 6–91PubMedCrossRefGoogle Scholar
  16. 16.
    Bullingham RES, McQuay HJ, Moore A, Bennett MRD (1980) Buprenorphine kinetics. Clin Pharmacol Ther 28: 667–672PubMedCrossRefGoogle Scholar
  17. 17.
    Bullingham RES, McQuay HJ, Moore RA (1983) Clinical pharmacokinetics of narcotic agonist-antagonist drugs. Clin Pharmacokinet 8: 332–343PubMedCrossRefGoogle Scholar
  18. 18.
    Carl P, Crawford ME, Ravlo O, Bach V (1986) Longterm treatment with epidural opioids. A retrospective study comprising 150 patients treated with morphine chloride and buprenorphine. Anaesthesia 41: 32–38PubMedCrossRefGoogle Scholar
  19. 19.
    Carl P, Crawford ME, Madsen NBB, Ravlo O, Bach V, Larsen AI (1987) Pain relief after major abdominal surgery: a double-blind controlled comparison of sublingual buprenorphine, intramuscular buprenorphine, and intramuscular meperidine. Anesth Analg 66: 142–146PubMedCrossRefGoogle Scholar
  20. 20.
    Caruso FS (1986) Butorphanol: clinical analgesic studies. Adv Pain Res Ther 8: 253–257Google Scholar
  21. 21.
    Coltart DJ, Malcolm AD (1979) Pharmacological and clinical importance of narcotic antagonists and mixed agonists - use in cardiology. Br J Clin Pharmacol 7 (Suppl 3): 309S - 313SPubMedCrossRefGoogle Scholar
  22. 22.
    Dadabhoy ZP, Tapia DP, Zsigmond EK (1985) Transplacental transfer of nalbuphine in patients undergoing cesarean section. Anesthesiology 64: 205Google Scholar
  23. 23.
    Derbyshire DR, Vater M, Maile CID, Larsson IM, Aitkenhead AR, Smith G (1984) Non-parenteral postoperative analgesia. A comparison of sublingual buprenorphine and morphine sulphate (slow release) tablets. Anaesthesia 39: 324–328Google Scholar
  24. 24.
    Dick W, Knoche E, Grundlach G, Klein I (1983) Klinisch experimentelle Untersuchungen zur postoperativen Infusionsanalgesie. Anaesthesist 32: 272–278PubMedGoogle Scholar
  25. 25.
    Downing JW, Goodwin NM, Hicks J (1979) The respiratory depressive effect of intravenous buprenorphine in patients in an intensive care unit. S Afr Med J 55: 1023–1027PubMedGoogle Scholar
  26. 26.
    Dryden GE (1986) Voluntary respiratory effects of butorphanol and fentanyl following barbiturate induction: a double-blind study. J Clin Pharmacol 26: 203–207PubMedCrossRefGoogle Scholar
  27. 27.
    Dudziak R (Hrsg) (1984) Nalbuphin. Ein neues Therapiekonzept in der postoperativen Phase. Perimed-Verlag, ErlangenGoogle Scholar
  28. 28.
    Engineer S, Jennett S (1972) Respiratory depression following single and repeated doses of pentazocine and pethidine. Br J Anaesth 44: 795–802PubMedCrossRefGoogle Scholar
  29. 29.
    Errick JK, Heel RC (1983) Nalbuphine. A preliminary review of its pharmacological properties and therapeutic efficacy. Drugs 26: 191–211Google Scholar
  30. 30.
    Finch JS (1980) Analgesic comparison of propiram fumarate with pentazocine, codeine and placebo in postsurgical pain. J Clin Pharmacol 20: 689–692PubMedCrossRefGoogle Scholar
  31. 31.
    Forrest WH, Brown CR, Shroff PF, Teutsch G (1972) Relative potency of propiram and morphine for analgesia in man. J Clin Pharmacol 12: 440–448Google Scholar
  32. 32.
    Frank M, McAteer EJ, Cattermole R, Loughnan B, Stafford LB, Hitchcock AM (1987) Nalbuphine for obstetric analgesia. A comparison of nalbuphine with pethidine for pain relief in labour when administered by patient-controlled analgesia ( PCA ). Anaesthesia 42: 696–703Google Scholar
  33. 33.
    Fry ENS (1984) Postoperative analgesia: a technique using continupus infusion of buprenorphine. Anaesthesia 39: 1134–1135PubMedCrossRefGoogle Scholar
  34. 34.
    Freye E, Azevedo L, Hartung E (1985) Reversal of fentanyl related respiratory depression with nalbuphine. Effects on the CO2-response curve in man. Acta Anaesthesiol Belg 36: 365–374PubMedGoogle Scholar
  35. 35.
    Freye E, Ciaramelli F, Fournell A (1986) Nalbuphine versus pentazocine in postoperative pain after orthopaedic surgery–a double-blind study. Schmerz-Pain-Douleur 7: 101–105Google Scholar
  36. 36.
    Freye E, Helle G (1988) Der Agonist-Antagonist Nalbuphin verlängert die gastrocoekale Transitzeit and induziert kurzfristig Schmerzen nach Neuroleptanalgesie mit Fentanyl. Eine Vergleichsuntersuchung zu Plazebo. Anaesthesist 37: 400–445Google Scholar
  37. 37.
    Gal TJ, DiFazio CA, Moscicki J (1982) Analgesic and respiratory depressant activity of nalbuphine: a comparison with morphine. Anesthesiology 57: 367–374PubMedCrossRefGoogle Scholar
  38. 38.
    Galloway FM, Varma S (1986) Double-blind comparison of intravenous dose of dezocine, butorphanol, and placebo for relief of postoperative pain. Anesth Analg 65: 283–287PubMedCrossRefGoogle Scholar
  39. 39.
    Garfield JM, Garfield FB, Philips BK, Earls D, Roaf E (1987) A comparison of clinical and physiological effects of fentanyl and nalbuphine in ambulatory gynecologic patients. Anesth Analg 66: 1303–1307PubMedCrossRefGoogle Scholar
  40. 40.
    Gepts E, Sonck WA, Camu F, Vercruysse A (1987) Pharmacokinetics of intravenously administered meptazinol during general anaesthesia in man. Eur J Anaesth 4: 35–43Google Scholar
  41. 41.
    Greenbaum RA, Kaye G, Mason PD (1987) Experience with nalbuphine, a new opioid analgesic, in acute myocardial infarction. J R Soc Med 80: 418–421PubMedGoogle Scholar
  42. 42.
    Gundersen RY, Andersen R, Narverud G (1986) Postoperative pain relief with high-dose epidural buprenorphine: a double-blind study. Acta Anaesthesiol Scand 30: 664–667PubMedCrossRefGoogle Scholar
  43. 43.
    Harmer M, Slattery PJ, Rosen M, Vickers MD (1983) Comparison between buprenorphine and pentazocine given i.v. on demand in the control of postoperative pain. Br J Anaesth 55: 21–25PubMedCrossRefGoogle Scholar
  44. 44.
    Hayes MJ, Fraser AR, Hampton JR (1979) Randomized trial comparing buprenorphine and diamorphine for chest pain in suspected myocardial infarction. Br Med J 2: 300–302PubMedCrossRefGoogle Scholar
  45. 45.
    Heel RC, Brogden RN, Speight TM, Avery GS (1979) Buprenorphine: a review of its pharmacological properties and therapeutic efficacy. Drugs 17: 81–110PubMedCrossRefGoogle Scholar
  46. 46.
    Hoffbrand BI, Turner P (eds) (1983) Clinical experience with injectable meptazinol - a new strong analgesic. Postgrad Med J 59 (Suppl 1)Google Scholar
  47. 47.
    Holmes B, Ward A (1985) Meptazinol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs 30: 285–312Google Scholar
  48. 48.
    Hovell BC (1977) Comparison of buprenorphine, pethidine and pentazocine for the relief of pain after operation. Br J Anaesth 49: 913–916PubMedCrossRefGoogle Scholar
  49. 49.
    Jaffe RS, Moldenhauer CC, Hug CC, Finlayson DC, Tobia V, Kopel ME (1988) Nalbuphine antagonism of fentanyl-induced ventilatory depression: a randomized trial. Anesthesiology 68: 254–268PubMedCrossRefGoogle Scholar
  50. 50.
    Jurna I (1987) Buprenorphin (Temgesic®). Pharmakologie und klinische Anwendung. Der Schmerz 1: 45–51PubMedCrossRefGoogle Scholar
  51. 51.
    Kaiko RF, Wallenstein SL, Rogers AG, Canel A, Jacobs B, Houde RW (1985) Intramuscular meptazinol and morphine in postoperative pain. Clin Pharmacol Ther 37: 589–596PubMedCrossRefGoogle Scholar
  52. 52.
    Kalia PK, Madan R, Saksena R, Batra RK, Gode GR (1983) Epidural pentazocine for postoperative pain relief. Anesth Analg 62: 949–950PubMedCrossRefGoogle Scholar
  53. 53.
    Kallos T, Caruso FS (1979) Respiratory effects of butorphanol and pethidine. Anaesthesia 34: 633–637PubMedCrossRefGoogle Scholar
  54. 54.
    Kay NH Butorphanol tartrate. In: Bullingham RES (eds) Opiate Analgesia. Saunders, London, pp 153–155Google Scholar
  55. 55.
    Kay NH, Allen MC, Bullingham RES, Baldwin D, McQuay HJ, Moore RA, Price PK, Sear JW (1985) Influence of meptazinol on metabolic and hormonal responses following major surgery. A comparison with morphine. Anaesthesia 40: 223–228Google Scholar
  56. 56.
    Kay B, Healy TEJ, Bolder PM (1985) Blocking the circulatory responses to tracheal intubation. A comparison of fentanyl and nalbuphine. Anaesthesia 40: 960–963Google Scholar
  57. 57.
    Kay B, Krishnan A (1986) On-demand nalbuphine for post-operative pain relief. Acta Anaesthesiol Belg 37: 33–37PubMedGoogle Scholar
  58. 58.
    Keup W (1984) Zentral wirksame Analgetika: Mißbrauch als Drogen-Ersatzmittel. Dtsch Ärzteblatt 81: 2561–2566Google Scholar
  59. 59.
    Kläy K, Gassmann AE (1978) Vergleichende Doppelblind-Studie über analgetische Wirksamkeit, Verträglichkeit und respiratorische Nebenwirkungen von Tilidin und Pentazocin in der postoperativen Phase. Schweiz Rundschau Med (PRAXIS) 67: 398406Google Scholar
  60. 60.
    Klepper ID, Rosen M, Vickers MD, Mapleson WW (1986) Respiratory function following nalbuphine and morphine in anaesthetized man. Br J Anaesth 58: 625629Google Scholar
  61. 61.
    de Klerk G, Mattie H, Spierdijk J (1981) Comparative study on the circulatory and respiratory effects of buprenorphine and methadone. Acta Anaesthesiol Belg 32: 131139Google Scholar
  62. 62.
    Knape JTA (1986) Early respiratory depression resistant to naloxone following epidural buprenorphine. Anesthesiology 64: 382–384PubMedCrossRefGoogle Scholar
  63. 63.
    Knoche E, Dick W, Rummel C, Konietzke D (1988) Untersuchungen zur Qualität von Buprenorphin bzw. Morphin als Komponenten einer Kombinationsnarkose. Anaesthesist 37: 57–64Google Scholar
  64. 64.
    Korduba CA, Veals J, Radwanski E, Symchowicz S, Chung M (1981) Bioavailability of orally administered propiram fumarate in humans. J Pharm Sci 70: 521–523PubMedCrossRefGoogle Scholar
  65. 65.
    Kubicki S, Neuhaus GA (Hrsg) (1981) Pentazocin im Spiegel der Erfahrungen. Springer, Berlin Heidelberg New YorkGoogle Scholar
  66. 66.
    Lake CL, Duckworth EN, DiFazio CA, Magruder MR (1984) Cardiorespiratory effects of nalbuphine and morphine premedication in adult cardiac surgical patients. Acta Anaesthesiol Scand 28: 305–309PubMedCrossRefGoogle Scholar
  67. 67.
    Lanz E, Simon G, Theiss D, Glocke MH (1984) Epidural buprenorphine–a double blind study of postoperative analgesia and side effects. Anesth Analg 63: 593–598PubMedCrossRefGoogle Scholar
  68. 68.
    Latasch L, Probst S, Dudziak R (1984) Reversal by nalbuphine of respiratory depression caused by fentanyl. Anesth Analg 63: 814–816PubMedCrossRefGoogle Scholar
  69. 69.
    Latasch L, Christ R (1986) Opiatrezeptoren. Anaesthesist 35: 55–65PubMedGoogle Scholar
  70. 70.
    Lee G, DeMaria A, Amsterdam EA, Realyvasquez E, Angel J, Morrison S, Mason DT (1976) Comparative effects of morphine, meperidine and pentazocine on cardiocirculatory dynamics in patients with acute myocardial infarction. Am J Med 60: 949–955PubMedCrossRefGoogle Scholar
  71. 71.
    Lee G, Low RI, Amsterdam EA, DeMaria AN, Huber PW, Mason DT (1981) Hemodynamic effects of morphine and nalbuphine in acute myocardial infarction. Clin Pharmacol Ther 29: 576–581PubMedCrossRefGoogle Scholar
  72. 72.
    Lehmann KA, Tenbuhs B, Hoeckle W (1985) Postoperative On-Demand Analgesie mit Pentazocin ( Fortral ). Langenbecks Arch Chir 367: 27–40Google Scholar
  73. 73.
    Lehmann KA, Tenbuhs B (1986) Patient-controlled analgesia with nalbuphine, a new narcotic agonist-antagonist for the treatment of postoperative pain. Eur J Clin Pharmacol 31: 267–276PubMedCrossRefGoogle Scholar
  74. 74.
    Lehmann KA, Gördes B (1988) Postoperative On-Demand Analgesic mit Buprenorphin. Anaesthesist 37: 65–70PubMedGoogle Scholar
  75. 75.
    Lehmann KA, Reichling U, Wirtz R (1988) Influence of naloxone on the postoperative analgesic and respiratory effects of buprenorphine. Eur J Clin Pharmacol 34: 343–352PubMedCrossRefGoogle Scholar
  76. 76.
    Lipp M, Daubländer M, Lanz E (1987) Buprenorphin 0.15 mg intrathecal zur postoperativen Analgesie. Eine klinische Doppelblindstudie. Anaesthesist 36: 233–238Google Scholar
  77. 77.
    Maunuksela EL, Korpela R, Olkkola KT (1988) Double-blind, multiple dose comparison of buprenorphine and morphine in postoperative pain of children. Br J Anaesth 60: 48–55PubMedCrossRefGoogle Scholar
  78. 78.
    McCammon RL, Stoelting RK, Madura JA (1984) Effects of butorphanol, nalbuphine, and fentanyl on intrabilary tract dynamics. Anesth Analg 63: 139–142PubMedCrossRefGoogle Scholar
  79. 79.
    Miller RR (1980) Evaluation of nalbuphine hydrochloride. Am J Hosp Pharm 37: 942949Google Scholar
  80. 80.
    Moldenhauer CC, Roach GW, Finlayson DC, Hug CC, Kopel ME, Tobia V, Kelly S (1985) Nalbuphine antagonism of ventilatory depression following high-dose fentanyl anesthesia. Anesthesiology 62: 647–650PubMedCrossRefGoogle Scholar
  81. 81.
    Molke Jensen F, Jensen NH, Holk IK, Ravnborg M (1987) Prolonged and biphasic respiratory depression following epidural buprenorphine. Anaesthesia 42: 470–475PubMedCrossRefGoogle Scholar
  82. 82.
    Morrison CE, Dutton D, Howie H, Gilmour h (1987) Pethidine compared with meptazinol during labour. A prospective randomized double-blind study with 1100 patients. Anaesthesia 42: 7–14Google Scholar
  83. 83.
    Neal EA, Meffin PJ, Gregory PB, Blaschke TF (1979) Enhanced bioavailability and decreased clearance of analgesics in patients with cirrhosis. Gastroenterology 77: 96–102PubMedGoogle Scholar
  84. 84.
    Nicholas ADG, Robson PH (1982) Double-blind comparison of meptazinol and pethidine in labour. Br J Obstet Gynaecol 89: 318–322PubMedCrossRefGoogle Scholar
  85. 85.
    Nimmo WS, Todd JG, Vogel J (1986) Effect of meptazinol on drug absorption and gastric emptying. Eur J Anaesth 3: 295–298Google Scholar
  86. 86.
    Orwin JM (1977) The effect of doxapram on buprenorphine respiratory depression. Acta Anaesthesiol Belg 28: 93–106PubMedGoogle Scholar
  87. 87.
    Pasqualucci V, Tantucci C, Paoletti F, Dottorini ML, Bifarini G, Belfiori R, Berioli MB, Sorbini CA (1987) Buprenorphine vs. morphine via the epidural route: a controlled comparative clinical study of respiratory effects and analgesic activity. Pain 29: 273–286PubMedCrossRefGoogle Scholar
  88. 88.
    Paymaster NJ (1977) Analgesia after operation. A controlled comparison of meptazinol, pentazocine and pethidine. Br J Anaesth 49: 1139–1146PubMedCrossRefGoogle Scholar
  89. 89.
    Pedersen JE, Chraemmer-Jorgensen B, Schmidt JF, Risbo A (1986) Peroperative buprenorphine: do high dosages shorten analgesia postoperatively? Acta Anaesthesiol Scand 30: 660–663PubMedCrossRefGoogle Scholar
  90. 90.
    Piepenbrock S, Zenz M, Gorus R, Link K, Reinhart K (1983) Buprenorphin and Pentazocin zur postoperativen Analgesie. Eine Doppelblindstudie nach Baucheingriffen. Anaesthesist 32: 601–609Google Scholar
  91. 91.
    Pittman KA, Smyth RD, Mayol RF (1980) Serum levels of butorphanol by radioimmunoassay. J Pharm Sci 69: 160–163PubMedCrossRefGoogle Scholar
  92. 92.
    Pond SM, Tong T, Benowitz NL, Jacob P (1980) Enhanced bioavailability of pethidine and pentazocine impatients with cirrhosis of the liver. Aust NZ J Med 10: 515–519CrossRefGoogle Scholar
  93. 93.
    Popio KA, Jackson DH, Ross AM, Schreiner BF, Yu PN (1978) Hemodynamic and respiratory effects of morphine and butorphanol. Clin Pharmacol Ther 23: 281–287PubMedGoogle Scholar
  94. 94.
    Pugh CC, Drummond GB (1987) A dose-response study with nalbuphine hydrochloride for pain in patients after upper abdominal surgery. Br J Anaesth 59: 1356–1363PubMedCrossRefGoogle Scholar
  95. 95.
    Pugh GC, Drummond GB, Elton RA, Macintyre CCA (1987) Constant i.v. infusions of nalbuphine or buprenorphine for pain after abdominal surgery. Br J Anaesth 59: 13641374Google Scholar
  96. 96.
    Radnay PA, Duncalf D, Novakovich M, Lesser ML (1984) Common bile duct pressure changes after fentanyl, morphine, meperidine, butorphanol, and naloxone. Anesth Analg 63: 441–444PubMedCrossRefGoogle Scholar
  97. 97.
    Ramsay JG, Higgs BD, Wynands JE, Robbins R, Townsend GE (1985) Early extubation after high-dose fentanyl anaesthesia for aortocoronary bypass surgery: reversal of respiratory depression with low-dose nalbuphine. Can Anaesth Soc J 32: 597–606PubMedCrossRefGoogle Scholar
  98. 98.
    Rance MJ (1979) Animal and molecular pharmacology of mixed agonist-antagonist analgesic drugs. Br J Clin Pharmacol 7: 281S - 286SPubMedCrossRefGoogle Scholar
  99. 99.
    Rao U, Campbell IT, Catley DM, Sutherst JR (1985) Epidural meptazinol for pain relief after lower abdominal surgery. Anaesthesia 40: 754–758PubMedCrossRefGoogle Scholar
  100. 100.
    von Rechenberg H, Knoch M, Konder H, Lennartz h (1986) Hämodynamische Einflüsse von Nalbuphin bei Patienten mit akuter respiratorischer Insuffizienz. Anaesthesist 35: 103–107Google Scholar
  101. 101.
    Richter W, von Arnim B, Giertz h (1981) Tramadol-Kapseln in der klinischen Doppelblindprüfung. 1. Mitteilung: Vergleich mit Pentazocin und Plazebo. MMW 123: 517–520Google Scholar
  102. 102.
    Ridley SA, Matthews NC, Dixon J (1986) Meptazinol versus pethidine for postoperative pain relief in children. Anaesthesia 41: 263–267PubMedCrossRefGoogle Scholar
  103. 103.
    Risbo A, Jorgensen BC, Kolby P, Pedersen J, Schmidt JF (1985) Sublingual buprenorphine for premedication and postoperative pain relief in orthopaedic surgery. Acta Anaesthesiol Scand 29: 180–182PubMedCrossRefGoogle Scholar
  104. 104.
    Ritschel WA (1982) Pharmacokinetic aspects of analgesics. Methods Find Exp Clin Pharmacol 4: 479–487PubMedGoogle Scholar
  105. 105.
    Robbie DS (1979) A trial of sublingual buprenorphine in cancer pain. Br J Clin Pharmacol 7 (Suppl 3): 315–317CrossRefGoogle Scholar
  106. 106.
    Romagnoli A, Keats AS (1980) Ceiling effect for respiratory depression by nalbuphine. Clin Pharmacol Ther 27: 478–485PubMedCrossRefGoogle Scholar
  107. 107.
    Rosow CE (1985) Newer synthetic opioid analgesics. In: Smith G, Covino BG (eds) Acute Pain. Butterworths, London, pp 68–103Google Scholar
  108. 108.
    Schäffer J, Piepenbrock S, Niekrens E, Panning B (1988) Nalbuphin im Vergleich mit Piritramid und Plazebo zur postoperativen Schmerztherapie nach Intubationsnarkosen mit Halothan. Anaesthesist 37: 238–245PubMedGoogle Scholar
  109. 109.
    Schaer H, Baasch K, Achtari R (1986) Nalbuphin nach Enfluran oder Fentanyl–Wirkungen auf Kreislauf und Atmung. Anaesthesist 35: 478–484PubMedGoogle Scholar
  110. 110.
    Schaer H, Baasch K, Achtari R (1987) Nalbuphin nach Fentanyl. Postoperative Analgesia. Anaesthesist 36: 166–171Google Scholar
  111. 111.
    Schmucker P, van Ackern K, Franke N, Noisser H, Militzer H, Peter K, Kreuzer E, Türk R (1980) Hämodynamische und respiratorische Effekte von Pentazocin. Untersuchungen an kardio-chirurgischen Patienten. Anaesthesist 29: 475–480Google Scholar
  112. 112.
    Scott DHT, Arthur R, Scott DB (1980) Haemodynamic changes following buprenorphine and morphine. Anaesthesia 35: 957–961PubMedCrossRefGoogle Scholar
  113. 113.
    Sear JW, Keegan M, Kay B (1987) Disposition of nalbuphine in patients undergoing general anaesthesia. Br J Anaesth 59: 572–575PubMedCrossRefGoogle Scholar
  114. 114.
    Shah M, Rosen M, Vickers MD (1984) Effect of premedication with diazepam, morphine or nalbuphine on gastrointestinal motility after surgery. Br J Anaesth 56: 1235–1238PubMedCrossRefGoogle Scholar
  115. 115.
    Sheikh A, Tunstall ME (1986) Comparative study of meptazinol and pethidine for the relief of pain in labour. Br J Obstetr Gynaecol 93: 264–269CrossRefGoogle Scholar
  116. 116.
    Slattery PJ, Harmer M, Rosen M, Vickers MD (1982) Naloxone reversal of meptazinolinduced respiratory depression. Anaesthesia 37: 1163–1166PubMedCrossRefGoogle Scholar
  117. 117.
    Spiller P, Kreuzer h (1974) Schmerzbekämpfung beim Myokardinfarkt. Z Kardiol 63: 1060–1067Google Scholar
  118. 118.
    Stambaugh JE (1982) Evaluation of nalbuphine: efficacy and safety in the management of chronic pain associated with advancedmalignancy. Curr Ther Res 31: 393–400Google Scholar
  119. 119.
    Sunshine A, Axtmayer R, Olson NZ, Laska E, Ramos I (1988) Analgesic efficacy of pentazocine versus a pentazocine-naloxone combination following oral administration. Clin J Pain 4: 35–40CrossRefGoogle Scholar
  120. 120.
    Tammisto T, Tigerstedt I (1977) Comparison of the analgesic effects of intravenous nalbuphine and pentazocine in patients with postoperative pain. Acta Anaesthesiol Scand 21: 390–394PubMedCrossRefGoogle Scholar
  121. 121.
    de Thibault de Boesinghe L (1978) Double-blind study of the analgesic effect of nefopam hydrochloride (Acupan®) and pentazocine (Fortral®) in cancer patients with pain. Curr Ther Res 24: 646–655Google Scholar
  122. 122.
    Verborgh C, van der Auwera D, Camu F (1987) Meptazinol for postoperative pain relief in man. Comparison of extradural and i.m. administration. Br J Anaesth 59: 1134–1139Google Scholar
  123. 123.
    Wallenstein SL, Rogers AG, Kaiko RF, Houde RW (1986) Nalbuphine: clinical analgesic studies.Adv Pain Res Ther 8: 247–252Google Scholar
  124. 124.
    Wilkinson DJ, O’Connor SA, Dickson GR, Drake HF (1985) Meptazinol-a cause of respiratory depression in general anaesthesia. Br J Anaesth 57: 1077–1084PubMedCrossRefGoogle Scholar
  125. 125.
    Yukioka H, Bogod DG, Rosen M (1987) Recovery of bowel motility after surgery. Detection of time to first flatus from carbon dioxide concentration and patient estimate after nalbuphine and placebo. Br J Anaesth 59: 581–584Google Scholar
  126. 126.
    Yukioka H, Rosen M, Evans KT, Leach KG, Hayward MWJ, Saggu GS (1987) Gastric emptying and small bowel transit times in volunteers after intravenous morphine and nalbuphine. Anaesthesia 42: 704–710PubMedCrossRefGoogle Scholar
  127. 127.
    Zenz M, Piepenbrock S, Tryba M, Klauke W, Everlien M (1983) BuprenorphinSublingual-Tabletten: Erste klinische Erfahrungen bei der Langzeittherapie von Krebsschmerzen. Fortschr Med 101: 191–194Google Scholar
  128. 128.
    Zinck B, Fritz KW (1982) Atemdepression nach epiduraler Opiat-Analgesie mit Buprenorphin-Hydrochlorid? Anaesth Intensivther Notfallmed 17: 345–347CrossRefGoogle Scholar
  129. 129.
    Zsigmond EK, Durrani Z, Barabas E, Wang XY, Tran L (1987) Endocrine and hemodynamic effects of antagonism of fentanyl-induced respiratory depression by nalbuphine. Anesth Analg 66: 421–426PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1990

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  • K. A. Lehmann

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