Dendritic Cell-Based Immunotherapy

  • T. G. Berger
  • E. S. Schultz
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 276)


Dendritic cell (DC)-based vaccinations represent a promising approach for the immunotherapy of cancer and infectious diseases as DCs play an essential role in initiating cellular immune responses. A number of clinical trials using ex vivo-generated DCs have been performed so far and only minor toxicity has been reported. Both the induction of antigen-specific T cells and clinical responses have been observed in vaccinated cancer patients. Nevertheless, DC-based immunotherapy is still in its infancy and there are many issues to be addressed such as antigen loading procedures, DC source and maturational state, migration properties, route, frequency, and dosage of DC vaccination. The increasing knowledge of DC biology should be used to improve the efficacy of this new therapy.


Dendritic Cell Tumor Antigen Human Dendritic Cell Dritic Cell CD1d Tetramer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • T. G. Berger
    • 1
  • E. S. Schultz
    • 1
  1. 1.Department of DermatologyUniversity of ErlangenErlangenGermany

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