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Dendritic Cells and Virus Infection pp 145–161Cite as

The Interaction Between Dendritic Cells and Herpes Simplex Virus-1

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Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY,volume 276)

Abstract

Dendritic cells (DCs) are the most potent antigen-presenting cells, because they are also able to induce native T cells. Thus they are crucial in the induction of antiviral immune responses. Several viral immune escape mechanisms have been described; here we concentrate on the interaction between DCs and herpes simplex virus type 1 (HSV-1). DCs can be infected by HSV-1; however, only immature DCs generate infectious viral particles, whereas mature DCs do not support virus production and only immediate-early and early viral transcripts are generated. To induce potent immune responses DCs must mature. Interestingly, HSV-1 interferes with this maturation process, thus inhibiting antiviral T cell stimulation. Furthermore, HSV-1 strongly interferes with DC-mediated T cell proliferation. A striking finding was the complete degradation of CD83, the best-known marker for mature DC, after HSV-1 infection in lysosomal compartments. This CD83 degradation coincided with a clearly reduced T cell stimulation representing an additional new escape strategy. The functional role and the importance of CD83 are discussed in detail.

Keywords

  • Herpes Simplex
  • Genital Herpes
  • Soluble CD83
  • Cell Stimulatory Capacity
  • CD83 Degradation

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  1. Department of Dermatology, University of Erlangen, Hartmannstrasse 14, 91052, Erlangen, Germany

    D. Kobelt, M. Lechmann & A. Steinkasserer

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  1. D. Kobelt
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  2. M. Lechmann
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  1. Dermatologische Klinik, Universität Erlangen, Hartmannstr. 14, 91052, Erlangen, Germany

    Prof. Dr. Alexander Steinkasserer

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Kobelt, D., Lechmann, M., Steinkasserer, A. (2003). The Interaction Between Dendritic Cells and Herpes Simplex Virus-1. In: Steinkasserer, A. (eds) Dendritic Cells and Virus Infection. Current Topics in Microbiology and Immunology, vol 276. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06508-2_7

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  • DOI: https://doi.org/10.1007/978-3-662-06508-2_7

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