Cellular Genealogy of In-Vitro Senescence and Immortalization

  • T. Matsumura
Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 24)


A population of mammalian somatic cells in culture in most cases terminates its proliferation after a period of vigorous growth. Occasionally, either through the action of extraneous effectors or spontaneously, it becomes immortalized, resulting in a continuously growing cell population (Hayflick and Moorhead 1961; Todaro and Green 1963).


Family Tree Polyploid Cell Human Diploid Cell Family Tree Analysis Proliferative Population 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • T. Matsumura
    • 1
  1. 1.Meiji Cell Technology CenterMeiji Milk Products Co.OdawaraJapan

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