Abstract
Monitoring of the adequacy of anticoagulation is essential to the safe conduct of cardiopulmonary bypass (CPB). While there is no universally accepted heparin level or test of adequate anticoagulation during cardio-pulmonary bypass, the automated activated clotting time (Hemochron ACT) became the routine method of monitoring heparinization in most cardiac centers, because of its simplicity, rapidity, and an observed linear relationship to the heparin dose [2, 3, 10]. However, hemodilution, coagulation-factor depletion, and hypothermia have all been shown to influence ACT and, thus, may lead to a non-heparin-induced prolongation of ACT. Furthermore, there is also no universally accepted safe minimum ACT for CPB [6, 12].
Keywords
- Cardiopulmonary Bypass
- Activate Clotting Time
- Extracorporeal Circulation
- Heparin Dose
- Heparin Concentration
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© 1991 Springer-Verlag Berlin Heidelberg
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Preiss, D.U., Witt, I., Kiefer, H., Betz, P. (1991). ACT and Aprotinin. In: Friedel, N., Hetzer, R., Royston, D. (eds) Blood Use in Cardiac Surgery. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-06119-0_40
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DOI: https://doi.org/10.1007/978-3-662-06119-0_40
Publisher Name: Steinkopff, Heidelberg
Print ISBN: 978-3-662-06121-3
Online ISBN: 978-3-662-06119-0
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