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Pathomechanisms of Defective Hemostasis During and After Extracorporeal Circulation: Contact Phase Activation

  • Conference paper
Blood Use in Cardiac Surgery

Abstract

Contact of blood with so-called foreign surfaces or macromolecular structures results in activation of both coagulation and fibrinolysis. This activation is mediated by the contact phase system. This system was originally discovered in vitro in relation to coagulation [13] and also fibrinolysis [12], but has since been implicated in several other processes and reactions, such as vasodilatation, activation of complement, of neutrophils, and of the renin/angiotensin system.

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Author information

Authors and Affiliations

  1. Gaubius Institute TNO, P.O. Box 612, 2300 AP, Leiden, The Netherlands

    C. Kluft

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  1. C. Kluft
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Editor information

Editors and Affiliations

  1. Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 1000, Berlin 65, Germany

    N. Friedel  & R. Hetzer  & 

  2. Harefield Hospital, Hill End Road, Harefield, Middlesex, UB9 6JH, UK

    D. Royston

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© 1991 Springer-Verlag Berlin Heidelberg

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Kluft, C. (1991). Pathomechanisms of Defective Hemostasis During and After Extracorporeal Circulation: Contact Phase Activation. In: Friedel, N., Hetzer, R., Royston, D. (eds) Blood Use in Cardiac Surgery. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-06119-0_2

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  • DOI: https://doi.org/10.1007/978-3-662-06119-0_2

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-06121-3

  • Online ISBN: 978-3-662-06119-0

  • eBook Packages: Springer Book Archive

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