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Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics pp 281–312Cite as

Toward Novel Vaccines and Therapies Based on Negative-Strand RNA Viruses

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 283))

Abstract

The study of negative-strand RNA viruses has suggested new strategies to produce more attenuated viruses. Reverse genetics has allowed the implementation of the strategies, and new or improved monovalent vaccines are being developed. In addition, recombinant viruses expressing foreign proteins or epitopes have been produced with the aim of developing multivalent vaccines capable of stimulating humoral and cellular immune responses against more than one pathogen. Finally, recombinant viruses that selectively enter cells expressing tumor markers or the HIV envelope protein have been engineered and shown to lyse target cells. Preclinical and clinical trials of improved and multivalent vaccines and therapeutic (oncolytic) viruses are ongoing.

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  1. Molecular Medicine Program, Mayo Foundation, 200 1st Street SW, Rochester, MN, 55905, USA

    V. von Messling & R. Cattaneo

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  1. V. von Messling
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  1. School of Veterinary Medicine Department of Pathobiological Sciences, University of Wisconsin-Madison, 2015 Linden Drive West, 535706, Madison, Wisconsin, USA

    Yoshihiro Kawaoka DVM, PhD

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von Messling, V., Cattaneo, R. (2004). Toward Novel Vaccines and Therapies Based on Negative-Strand RNA Viruses. In: Kawaoka, Y. (eds) Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics. Current Topics in Microbiology and Immunology, vol 283. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06099-5_8

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  • DOI: https://doi.org/10.1007/978-3-662-06099-5_8

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