Skip to main content

Umwelt- und arbeitsplatzbedingte Einflüsse auf die männliche Fertilität

  • Chapter
Andrologie

Zusammenfassung

Der Mensch ist sein gesamtes Leben hindurch unzählbaren, sehr unterschiedlichen, natürlich vorkommenden und synthetischen Stoffen ausgesetzt. Damit verbundene Risiken toxischer Einflüsse auf den menschlichen Organismus haben stets existiert, haben jedoch seit der industriellen Revolution durch die Synthese und industrielle Verbreitung neuartiger oder hoch angereicherter Verbindungen zweifelsfrei zugenommen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Akre O, Cnattingius S, Bergstrom R, Kvist U (1999) Human fertility does not decline: evidence from Sweden. Fertil Steril 71: 1066–1069

    Google Scholar 

  • Alexander BH, Checkoway H, van Netten C, Muller CH, Ewers TG, Kaufman JD, Mueller BA, Vaughan TL, Faustman EM (1996) Semen quality of men employed at a lead smelter. Occup Environ Med 53: 411–416

    PubMed  CAS  Google Scholar 

  • Anderson D, Brinkworth MH, Jenkinson PC, Clode SA, Creasy DM, Gangolli SD (1987) Effect of ethylene glycol monomethyl ether on spermatogenesis, dominant lethality, and F1 abnormalities in the rat and the mouse after treatment of Fo males. Teratog Carcinog Mutagen 7: 141–158

    PubMed  CAS  Google Scholar 

  • Anderson D, Edwards AJ, Brinkworth MH, Hughes JA (1996) Male-mediated F1 effects in mice exposed to 1,3-butadiene. Toxicology 113: 12o - 127

    Google Scholar 

  • Armour JAL, Brinkworth MH, Kamischke (1999) A direct analysis by small-pool PCR of MS2o5 minisatellite mutation rates in sperm after mutagenic therapies. Mut Res 15: 73–80

    Google Scholar 

  • Arnold SF, Klotz DM, Collins BM, Vonier PM, Guillette LJ Jr., McLachlan JA (1996) Synergistic activation of estrogen receptor with combinations of environmental chemicals. Science 272: 1489–1492

    PubMed  CAS  Google Scholar 

  • Ashby J, Odum J (1998) The importance of protocol design and data reporting to research on endocrine disruption. Environ Health Perspect 1o6:A315–316; discussion A316–317

    Google Scholar 

  • Ashby J, Tinwell H, Haseman J (1999) Lack of effects for low dose levels of bisphenol A (BPA) and diethylstilbestrol (DES) on the prostate gland of CFI mice exposed in utero. Regul Toxicol Pharmacol 30: 156–166

    Google Scholar 

  • Ashby J, Tinwell H, Lefevre PA, Odum J, Paton D, Millward SW, Tittensor S, Brooks AN (1997) Normal sexual development of rats exposed to butyl benzyl phthalate from conception to weaning. Regul Toxicol Pharmacol 26: 102–18

    Google Scholar 

  • Auger J, Kunstmann JM, Czyglik F, Jouannet P (1995) Decline in semen quality among fertile men in Paris during the past 20 years. N Engl J Med 332: 281–285

    Google Scholar 

  • Baker HW (1998) Reproductive effects of nontesticular illness. Endocrinol Metab Clin North Am 27: 831–850

    PubMed  CAS  Google Scholar 

  • Bartlett JM, Kerr JB, Sharpe RM (1986) The effect of selective destruction and regeneration of rat Leydig cells on the intratesticular distribution of testosterone and morphology of the seminiferous epithelium. J Androl 7: 240–253

    PubMed  CAS  Google Scholar 

  • Bartoov B, Zabludovsky N, Eltes F, Smirnov VV, Grischenko VI, Fischbein A (1997) Semen quality of workers exposed to ionizing radiation in decontamination work after the Chernobyl nuclear reactor accident. Int J Occup Environ Health 3: 198–203

    PubMed  Google Scholar 

  • Berndtson WE, Foote RH (1997) Disruption of spermatogenesis in rabbits consuming ethylene glycol monomethyl ether. Reprod Toxicol 1: 29–36

    Google Scholar 

  • Billig H, Furuta I, Rivier C, Tapanainen J, Parvinen M, Hsueh AJ (1995) Apoptosis in testis germ cells: developmental changes in gonadotropin dependence and localization to selective tubule stages. Endocrinology 136: 5–12

    PubMed  CAS  Google Scholar 

  • Bolumar F, Olsen J, Boldsen J (1996) Smoking reduces fecundity: a European multicenter study on infertility and subfecundity. The European Study Group on Infertility and Sub-fecundity. Am J Epidemiol 143: 578–587

    Google Scholar 

  • Boockfor FR, Blake CA (1997) Chronic administration of 4-tert-octylphenol to adult male rats causes shrinkage of the testes and male accessory sex organs, disrupts spermatogenesis, and increases the incidence of sperm deformities. Biol Reprod 57: 267–277

    PubMed  CAS  Google Scholar 

  • Boekelheide K (1993) Sertoli cell toxicants. In: Russell LD, Griswold MD (eds) The Sertoli Cell. Cache River Press, Clearwater, pp 551–575

    Google Scholar 

  • Bonde JP, Giwercman A (1995) Occupational hazards to male fecundity. Reprod Med Rev 4: 59–73

    Google Scholar 

  • Brake A, Krause W (1992) Decreasing quality of semen. Br Med 13051498

    Google Scholar 

  • Brandriff BF, Meistrich ML, Gordon LA, Carrano AV, Liang JC (1994) Chromosomal damage in sperm of patients surviving Hodgkin’s disease following MOPP (nitrogen mustard, vincristine, procarbazine, and prednisone) therapy with and without radiotherapy. Hum Genet 93:295–299

    Google Scholar 

  • Brinkworth MH (2000) Paternal transmission of genetic damage: findings in animals and humans. Int J Androl (in press)

    Google Scholar 

  • Brinkworth MH, Nieschlag E (1999) Association of cyclophosphamide-induced male-mediated, foetal abnormalities with reduced paternal germ-cell apoptosis. Mutat Res 447: 149–154

    Google Scholar 

  • Brinkworth MH, Anderson D, McLean AE (1992) Effects of dietary imbalances on spermatogenesis in CD-1 mice and CD rats. Food Chem Toxicol 30:29–35

    Google Scholar 

  • Brinkworth MH, Weinbauer GF, Schlatt S, Nieschlag E (1995) Identification of male germ cells undergoing apoptosis in adult rats. J Reprod Fertil 105:25–33

    Google Scholar 

  • Brondum J, Shu XO, Steinbuch M, Severson RK, Potter JD, Robison LL (1999) Parental cigarette smoking and the risk of acute leukemia in children. Cancer 85: 1380–1388

    Google Scholar 

  • Byrne J (1999) Long-term genetic and reproductive effects of ionizing radiation and chemotherapeutic agents on cancer patients and their offspring. Teratology 59:210–215

    Google Scholar 

  • Byrne J, Rasmussen SA, Steinhorn SC, Connelly RR, Myers MH, Lynch CF, Flannery J, Austin DF, Holmes FF, Holmes GE, Strong LC, Mulvihill JJ (1998) Genetic disease in offspring of long-term survivors of childhood and adolescent cancer. Am J Hum Genet 62:45–52

    Google Scholar 

  • Bujan L, Mansat A, Pontonnier F, Mieusset R (1996) Time series analysis of sperm concentration in fertile men in Toulouse, France between 1977 and 1992. Br Med J 312: 471–472

    CAS  Google Scholar 

  • Carlsen E, Giwercman A, Keiding N, Skakkebaek NE (1992) Evidence for decreasing quality of semen during past 50 years. Br Med J 305: 609–613

    CAS  Google Scholar 

  • Carson SA (1993) Mutagenic sensitivity of human post-spermatogonial cells. Hum Reprod 8:982

    Google Scholar 

  • Carson SA, Gentry WL, Smith AL, Buster JE (1991) Feasibility of semen collection and cryopreservation during chemotherapy. Hum Reprod 6:992–994

    Google Scholar 

  • Chapin RE, Heindel JJ (eds) (1993) Male reproductive toxicology. Methods in toxicology, volume 3, part A: male reproductive toxicology. Academic Press, San Diego New York Boston London Sydney Tokyo Toronto

    Google Scholar 

  • Chia SE, Ong CN, Lee ST, Tsakok FH (1992) Blood concentrations of lead, cadmium, mercury, zinc, and copper and human semen parameters. Arch Androl 29: 177–183

    PubMed  CAS  Google Scholar 

  • Cicero TJ, Meyer ER, Bell RD, Wiest WG (1974) Effects of morphine on the secondary sex organs and plasma testosterone levels of rats. Res Commun Chem Pathol Pharmacol 7: 17–24

    PubMed  CAS  Google Scholar 

  • Clegg ED, Cook JC, Chapin RE, Foster PM, Daston GP (1997) Leydig cell hyperplasia and adenoma formation: mechanisms and relevance to humans. Reprod Toxicol 11: 107–121

    PubMed  CAS  Google Scholar 

  • Cooke PS, Zhao YD, Hansen LG (1996) Neonatal polychlorinated biphenyl treatment increases adult testis size and sperm production in the rat. Toxicol Appl Pharmacol 136: 112–117

    PubMed  CAS  Google Scholar 

  • Cooper TG, Yeung CH (1999) Recent biochemical approaches to post-testicular, epididymal contraception. Hum Reprod Update 5: 141–152

    Google Scholar 

  • Creasy DM, Flynn JC, Gray TJ, Butler WH (1985) A quantitative study of stage-specific spermatocyte damage following administration of ethylene glycol monomethyl ether in the rat. Exp Mol Pathol 43:321–336

    Google Scholar 

  • de Jager C, Bornman MS, van der Horst G (1999) The effect of p-nonylphenol, an environmental toxicant with oestrogenic properties, on fertility potential in adult male rats. Andrologia 31: 99–106

    Google Scholar 

  • Doll R, Evans HJ, Darby SC (1994) Paternal exposure not to blame. Nature 367: 678–680

    PubMed  CAS  Google Scholar 

  • Dong Q, Rintala H, Handelsman DJ (1994) Androgen receptor function during undernutrition. J Neuroendocrinol 6: 397–402

    Google Scholar 

  • Draper GJ, Little MP, Sorahan T, Kinlen LJ, Bunch KJ, Conquest AJ, Kendall GM, Kneale GW, Lancashire RJ, Muirhead CR, O’Connor CM, Vincent TJ (1997) Cancer in the offspring of radiation workers: a record linkage study. Br Med J 315: 1181–1188

    Google Scholar 

  • Dubrova YE, Nesterov VN, Krouchinsky NG, Ostapenko VA, Neumann R, Neil DL, Jeffreys AJ (1996) Human minisatellite mutation rate after the Chernobyl accident. Nature 380: 683–686

    PubMed  CAS  Google Scholar 

  • Dubrova YE, Plumb M, Brown J, Jeffreys AJ (1998) Radiation-induced germline instability at minisatellite loci. Int J Radi-at Biol 74: 689–696

    CAS  Google Scholar 

  • Eaton M, Schenker M,Whorton MD, Samuels S, Perkins C, Overstreet J (1986) Seven-year follow-up of workers exposed to 1,2-dibromo-3-chloropropane. J Occup Med 28x1451150

    Google Scholar 

  • Eddy EM, Washburn TF, Bunch DO, Goulding EH, Gladen BC, Lubahn DB, Korach KS (1996) Targeted disruption of the es-trogen receptor gene in male mice causes alteration of spermatogenesis and infertility. Endocrinology 13747964805

    Google Scholar 

  • Egger M, Schneider M, Davey Smith G (1998) Spurious precision? Meta-analysis of observational studies. Br Med J 316: 140–144

    CAS  Google Scholar 

  • Fan YJ, Wang Z, Sadamoto S, Ninomiya Y, Kotomura N, Kamiya K, Dohi K, Kominami R, Niwa O (1995) Dose-response of a radiation induction of a germline mutation at a hypervariable mouse minisatellite locus. Int J Radiat Biol 68: 177–183

    Google Scholar 

  • Figa-Talamanca I, Dell’Orco V, Pupi A, Dondero F, Gandini L, Lenzi A, Lombardo F, Scavalli P, Mancini G (1992) Fertility and semen quality of workers exposed to high temperatures in the ceramics industry. Reprod Toxicol 6:517–523

    Google Scholar 

  • Finkelstein JS, McCully WF, MacLaughlin DT, Godine JE, Crowley WF, Jr. (1988) The mortician’s mystery. Gynecomastia and reversible hypogonadotropic hypogonadism in an embalmer. N Engl J Med 318: 961–965

    Google Scholar 

  • Fisch H, Goluboff ET (1996) Geographic variations in sperm counts: a potential cause of bias in studies of semen quality. Fertil Steril 65: 1044–1046

    PubMed  CAS  Google Scholar 

  • Fisch H, Golub off ET, Olson JH, Feldshuh J, Broder SJ, Barad DH (1996) Semen analyses in 1,283 men from the United States over a 25-year period: no decline in quality. Fertil Steril 65: 1009–1014

    PubMed  CAS  Google Scholar 

  • Fisher JS, Turner KJ, Brown D, Sharpe RM (1999) Effect of neonatal exposure to estrogenic compounds on development of the excurrent ducts of the rat testis through puberty to adulthood. Environ Health Perspect 107:397-405

    Google Scholar 

  • Fraga CG, Motchnik PA, Wyrobek AJ, Rempel DM, Ames BN (1996) Smoking and low antioxidant levels increase oxidative damage to sperm DNA. Mutat Res 351: 199–203

    PubMed  Google Scholar 

  • Furuchi T, Masuko K, Nishimune Y, Obinata M, Matsui Y (1996) Inhibition of testicular germ cell apoptosis and differentiation in mice misexpressing Bd-2 in spermatogonia. Development 122: 1703–1709

    PubMed  CAS  Google Scholar 

  • Gardner MJ, Snee MP, Hall AJ, Powell CA, Downes S, Terrell JD (1990) Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. Br Med J 300:423–429

    Google Scholar 

  • Giwercman A, Bonde JP (1998) Declining male fertility and environmental factors. Endocrinol Metab Clin North Am 27:807–830, viii

    Google Scholar 

  • Golden RJ, Noller KL, Titus-Ernstoff L, Kaufman RH, Mittendorf R, Stillman R, Reese EA (1998) Environmental endocrine modulators and human health: an assessment of the biological evidence. Crit Rev Toxicol 28: 109–227

    PubMed  CAS  Google Scholar 

  • Goldsmith JR (1997) Epidemiologic evidence relevant to radar (microwave) effects. Environ Health Perspect 105 Suppl 6: 1579–1587

    Google Scholar 

  • Hales BF, Robaire B (1993) Paternally mediated effects on progeny outcome. In: Whitcomb RW, Zirkin BR (eds) Understanding male fertility: Basic and clinical approaches. Raven Press, New York, pp 307–320

    Google Scholar 

  • Handelsman DJ (1997) Sperm output of healthy men in Australia: magnitude of bias due to self-selected volunteers. Hum Reprod 12: 2701–2705

    PubMed  CAS  Google Scholar 

  • Harrington JM, Stein GF, Rivera RO, de Morales AV (1978) The occupational hazards of formulating oral contraceptives-a survey of plant employees. Arch Environ Health 33: 12–15

    PubMed  CAS  Google Scholar 

  • Hess RA (1990) Quantitative and qualitative characteristics of the stages and transitions in the cycle of the rat seminiferous epithelium: light microscopic observations of perfusion-fixed and plastic-embedded testes. Biol Reprod 43: 525–542

    PubMed  CAS  Google Scholar 

  • Hess RA, Bunick D, Lee KH, Bahr J, Taylor JA, Korach KS, Lu-bahn DB (1997) A role for oestrogens in the male reproductive system. Nature 390: 509–512

    PubMed  CAS  Google Scholar 

  • Hjollund NH, Bonde JP, Jensen TK, Ernst E, Henriksen TB, Kolstad HA, Giwercman A, Skakkebaek NE, Olsen J (1998a) Semen quality and sex hormones with reference to metal welding. Reprod Toxicol 12:91–95

    Google Scholar 

  • Hjollund NH, Bonde JP, Jensen TK, Henriksen TB, Kolstad HA, Ernst E, Giwercman A, Pritzl G, Skakkebaek NE, Olsen J (1998b) A follow-up study of male exposure to welding and time to pregnancy. Reprod Toxicol 12: 29–37

    PubMed  CAS  Google Scholar 

  • Hjollund NH, Skotte JH, Kolstad HA, Bonde JP (1999) Extremely low frequency magnetic fields and fertility: a follow up study of couples planning first pregnancies. The Danish First Pregnancy Planner Study Team. Occup Environ Med 56:253-255

    Google Scholar 

  • Irvine S, Cawood E, Richardson D, MacDonald E, Aitken J (1996) Evidence of deteriorating semen quality in the United Kingdom: birth cohort study in 577 men in Scotland over n years. Br Med J 312: 467–471

    CAS  Google Scholar 

  • Jensh RP (1997) Behavioral teratologic studies using microwave radiation: is there an increased risk from exposure to cellular phones and microwave ovens? Reprod Toxicol 11: 601–611

    PubMed  CAS  Google Scholar 

  • Ji BT, Shu XO, Linet MS, Zheng W, Wacholder S, Gao YT, Ying DM, Jin F (1997) Paternal cigarette smoking and the risk of childhood cancer among offspring of nonsmoking mothers. J Natl Cancer Inst 89: 238–244

    PubMed  CAS  Google Scholar 

  • Jockenhövel F (1993) Hypogonadism and infertility as sequelae of general diseases and toxins. Internist (Berl) 34741755

    Google Scholar 

  • Joffe M, Villard L, Li Z, Plowman R,Vessey M (1993) Long-term recall of time-to-pregnancy. Fertil Steril 60: 99–104

    Google Scholar 

  • Joffe M, Bisanti L, Apostoli P, Shah N, Kiss P, Dale A, Roeleveld N, Lindbohm ML, Sallmen M, Bonde JP (1999) Time to pregnancy and occupational lead exposure. Asclepios. Scand J Work Environ Health 25: 64–65

    Google Scholar 

  • Kandeel FR, Swerdloff RS (1988) Role of temperature in regulation of spermatogenesis and the use of heating as a method for contraception. Fertil Steril 49: 1–23

    PubMed  CAS  Google Scholar 

  • Keck C, Bramkamp G, Behre HM, Muller C, Jockenhovel F, Nie-schlag E (1995) Lack of correlation between cadmium in seminal plasma and fertility status of nonexposed individuals and two cadmium-exposed patients. Reprod Toxicol 9:35-40

    Google Scholar 

  • Kelce WR, Wilson EM (1997) Environmental antiandrogens: developmental effects, molecular mechanisms, and clinical implications. J Mol Med 75: 198–207

    PubMed  CAS  Google Scholar 

  • Kerr JB (1992) Spontaneous degeneration of germ cells in normal rat testis: assessment of cell types and frequency during the spermatogenic cycle. J Reprod Fertil 95: 825–830

    PubMed  CAS  Google Scholar 

  • Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. BY J Cancer 26: 239–257

    CAS  Google Scholar 

  • Keys A (ed) (1950) The biology of human starvation. University of Minnesota Press, Minneapolis

    Google Scholar 

  • Kinlen LJ, Clarke K, Hudson C (1990) Evidence from population mixing in British New Towns 1946–85 of an infective basis for childhood leukaemia. Lancet 336: 577–582

    PubMed  CAS  Google Scholar 

  • Kinlen LJ, Clarke K, Balkwill A (1993) Paternal preconceptional radiation exposure in the nuclear industry and leukaemia and non-Hodgkin’s lymphoma in young people in Scotland. Br Med J 306: 1153–1158

    Google Scholar 

  • Knudson CM, Tung KS, Tourtellotte WG, Brown GA, Korsmeyer SI (1995) Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270: 96–99

    Google Scholar 

  • Kodama K, Mabuchi K, Shigematsu I (1996) A long-term cohort study of the atomic-bomb survivors. J Epidemiol 6: 595–105

    Google Scholar 

  • Lancranjan I, Popescu HI, O GA, Klepsch I, Serbanescu M (1975) Reproductive ability of workmen occupationally exposed to lead. Arch Environ Health 30: 396–401

    PubMed  CAS  Google Scholar 

  • Larsen SB, Giwercman A, Spano M, Bonde JP (1998) A longitudinal study of semen quality in pesticide spraying Danish farmers. The ASCLEPIOS Study Group. Reprod Toxicol 12: 581–589

    Google Scholar 

  • Lee J, Richburg JH, Younkin SC, Boekelheide K (1997) The Fas system is a key regulator of germ cell apoptosis in the testis. Endocrinology 138: 2081–2088

    PubMed  CAS  Google Scholar 

  • Lee J, Richburg JH, Shipp EB, Meistrich ML, Boekelheide K (1999) The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. Endocrinology 140: 852–858

    PubMed  CAS  Google Scholar 

  • Lerchl A, Nieschlag E (1996) Decreasing sperm counts? A criti- cal (re)view. Exp Clin Endocrinol Diabetes 104: 301–307

    PubMed  CAS  Google Scholar 

  • Lerchl A, Keck C, Spiteri-Grech J, Nieschlag E (1993) Diurnal variations in scrotal temperature of normal men and patients with varicocele before and after treatment. Int J Androl 16: 195–200

    Google Scholar 

  • Levine RJ, Symons MJ, Balogh SA, Arndt DM, Kaswandik NT, Gentile JW (1980) A method for monitoring the fertility of workers. 1. Method and pilot studies. J Occup Med 22: 781–791

    Google Scholar 

  • Linder RE, Klinefelter GR, Strader LF, Veeramachaneni DN, Roberts NL, Suarez JD (1997) Histopathologic changes in the testes of rats exposed to dibromoacetic acid. Reprod Toxicol 11: 47–56

    PubMed  CAS  Google Scholar 

  • Lord BI, Woolford LB, Wang L, Stones VA, McDonald D, Lori-more SA, Papworth D, Wright EG, Scott D (1998) Tumour induction by methyl-nitro so-urea following preconceptional paternal contamination with plutonium-239. Br J Cancer 78: 301–311

    PubMed  CAS  Google Scholar 

  • Lundsberg LS, Bracken MB, Belanger K (1995) Occupationally related magnetic field exposure and male subfertility. Fertil Steril 63: 384–391

    Google Scholar 

  • MacLeod J, Wang Y (1979) Male fertility potential in terms of semen quality: a review of the past, a study of the present. Fertil Steril 31: 103–116

    PubMed  CAS  Google Scholar 

  • McLachlan JA (1997) Synergistic effect of environmental estrogens: report withdrawn. Science 277: 462–463

    PubMed  CAS  Google Scholar 

  • Meistrich ML (1993) Potential genetic risks of using semen col-

    Google Scholar 

  • lected during chemotherapy. Hum Reprod 8:8-to Meistrich ML, van Beek MEAB (1990) Radiation sensitivity of the human testis. Adv Radiat Biol 14:227–268

    Google Scholar 

  • Mieusset R, Bujan L (1994) The potential of mild testicular heating as a safe, effective and reversible contraceptive method for men. Int J Androl 17: 186–191

    Google Scholar 

  • Mieusset R, Quintana Casares P, Sanchez Partida LG, Sower-butts SF, Zupp JL, Setchell BP (1992) Effects of heating the testes and epididymides of rams by scrotal insulation on fertility and embryonic mortality in ewes inseminated with frozen semen. J Reprod Fertil 94: 337–343

    PubMed  CAS  Google Scholar 

  • Mylchreest E, Sar M, Cattley RC, Foster PM (1999) Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide. Toxicol Appl Pharmacol 156: 81–95

    PubMed  CAS  Google Scholar 

  • Nagel SC, vom Saal FS, Thayer KA, Dhar MG, Boechler M, Welshons WV (1997) Relative binding affinity-serum modified access ( RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol. Environ Health Perspect 105: 70–76

    Google Scholar 

  • Neel JV (1998) Reappraisal of studies concerning the genetic effects of the radiation of humans, mice, and Drosophila. Environ Mol Mutagen 31: 4–10

    PubMed  CAS  Google Scholar 

  • Nelson CM, Bunge RG (1974) Semen analysis: evidence for changing parameters of male fertility potential. Fertil Steril 25: 503–507

    PubMed  CAS  Google Scholar 

  • Niehaus M, Bruggemeyer H, Behre HM, Lerchl A (1997) Growth retardation, testicular stimulation, and increased melatonin synthesis by weak magnetic fields (5o Hz) in Djungarian hamsters, Phodopus sungorus. Biochem Biophys Res Cornmun 234: 707–711

    CAS  Google Scholar 

  • Oberlander G,Yeung CH, Cooper TG (1994) Induction of reversible infertility in male rats by oral ornidazole and its effects on sperm motility and epididymal secretions. J Reprod Fertil 100:551–559

    Google Scholar 

  • Olsen GW, Bodner KM, Ramlow JM, Ross CE, Lipshultz LI (1995) Have sperm counts been reduced 5o percent in 5o years? A statistical model revisited. Fertil Steril 63: 887–893

    Google Scholar 

  • Pajarinen JT, Karhunen PJ (1994) Spermatogenic arrest and `Sertoli cell-only’ syndrome–common alcohol-induced disorders of the human testis. Int J Androl 17: 292–299

    Google Scholar 

  • Parker L, Pearce MS, Dickinson HO,Aitkin M, Craft AW (1999) Stillbirths among offspring of male radiation workers at Sellafield nuclear reprocessing plant. Lancet 354:1407–1414

    Google Scholar 

  • Paulsen CA, Berman, NG, Wang C (1996) Data from men in greater Seattle area reveals no downward trend in semen quality: further evidence that deterioration of semen quality is not geographically uniform. Fertil Steril 65: 1015–1020

    PubMed  CAS  Google Scholar 

  • Potts RJ, Newbury CJ, Smith G, Notarianni LJ, Jefferies TM (1999) Sperm chromatin damage associated with male smoking. Mutat Res 423x03–111

    Google Scholar 

  • Print CG, Loveland KL, Gibson L, Meehan T, Stylianou A, Wreford N, de Kretser D, Metcalf D, Kontgen F, Adams JM, Cory S (1998) Apoptosis regulator bd-w is essential for spermatogenesis but appears otherwise redundant. Proc Natl Acad Sci U S A 95: 12424–12431

    PubMed  CAS  Google Scholar 

  • Rodriguez I, Ody C, Araki K, Garcia I, Vassalli P (1997) An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis. Embo J 16: 2262–2270

    PubMed  CAS  Google Scholar 

  • Rousseaux S, Sele B, Cozzi J, Chevret E (1993) Immediate rearrangements of human sperm chromosomes following in-vivo irradiation. Hum Reprod 8: 903–907

    PubMed  CAS  Google Scholar 

  • Rowley MJ, Leach DR, Warner GA, Heller CG (1974) Effect of graded doses of ionizing radiation on the human testis. Radiat Res 59: 665–678

    PubMed  CAS  Google Scholar 

  • Sankila R, Olsen JH,Anderson H, Garwicz S, Glattre E, Hertz H, Langmark F, Lanning M, Moller T, Tulinius H (1998) Risk of cancer among offspring of childhood-cancer survivors. Association of the Nordic Cancer Registries and the Nordic Society of Paediatric Haematology and Oncology. N Engl J Med 338: 1339–1344

    Google Scholar 

  • Seed J, Chapin RE, Clegg ED, Dostal LA, Foote RH, Hurtt ME, Klinefelter GR, Makris SL, Perreault SD, Schrader S, Seyler D, Sprando R, Treinen KA, Veeramachaneni DN, Wise LD (1996) Methods for assessing sperm motility, morphology, and counts in the rat, rabbit, and dog: a consensus report. ILSI Risk Science Institute Expert Working Group on Sperm Evaluation. Reprod Toxicol 10: 237–244

    Google Scholar 

  • Setchell BP (1997) Sperm counts in semen of farm animals 1932–1995. Int J Androl 20: 209–214

    PubMed  CAS  Google Scholar 

  • Setchell BP (1998) The Parkes Lecture. Heat and the testis. J Reprod Fertil 114: 179–194

    PubMed  CAS  Google Scholar 

  • Setchell BP, Ekpe G, Zupp JL, Surani MA (1998) Transient retardation in embryo growth in normal female mice made pregnant by males whose testes had been heated. Hum Reprod 13: 342–347

    PubMed  CAS  Google Scholar 

  • Sharpe RM (1993) Declining sperm counts in men - is there an endocrine cause? J Endocrino1136:357–360

    Google Scholar 

  • Sharpe RM, Skakkebaek NE (1993) Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341: 1392–1395

    Google Scholar 

  • Sharpe RM, Fisher JS, Millar MM, Jobling S, Sumpter JP (1995) Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production. Environ Health Perspect 103: 1136–1143

    PubMed  CAS  Google Scholar 

  • Sharpe RM, Atanassova N, McKinnell C, Parte P, Turner KJ, Fisher JS, Kerr JB, Groome NP, Macpherson S, Millar MR, Saunders PT (1998) Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethylstilbestrol: a possible role for estrogens in Sertoli cell development. Biol Reprod 59: 1084–1094

    PubMed  CAS  Google Scholar 

  • Skakkebaek NE, Rajpert-De Meyts E, Jorgensen N, Carlsen E, Petersen PM, Giwercman A, Andersen AG, Jensen TK, Andersson AM, Muller J (1998) Germ cell cancer and disorders of spermatogenesis: an environmental connection? Apmis 106: 3–11

    PubMed  CAS  Google Scholar 

  • Skotte JH, Hjollund HI (1997) Exposure of welders and other metal workers to ELF magnetic fields. Bioelectromagnetics 18: 470–477

    PubMed  CAS  Google Scholar 

  • Sloan DG (1982) Male fertility potential. Fertil Steril 37:126 Sohoni P, Sumpter JP (1998) Several environmental oestrogens are also anti-androgens. J Endocrino1158:327–339

    Google Scholar 

  • Sorahan T, Lancashire RJ, Hulten MA, Peck I, Stewart AM (1997a) Childhood cancer and parental use of tobacco:deaths from 1953 to 1955. Br J Cancer 75: 134–138

    CAS  Google Scholar 

  • Sorahan T, Prior P, Lancashire RJ, Faux SP, Hulten MA, Peck IM, Stewart AM (1997b) Childhood cancer and parental use of tobacco: deaths from 1971 to 1976. Br J Cancer 76x5251531

    Google Scholar 

  • Sullivan FM (1988) Reproductive toxicity tests: retrospect and prospect. Hum Toxicol 7:423–427

    Google Scholar 

  • Tapanainen JS, Tilly JL, Vihko KK, Hsueh AJ (1993) Hormonal control of apoptotic cell death in the testis: gonadotropins and androgens as testicular cell survival factors. Mol Endocrinol 7: 643–650

    Google Scholar 

  • Thonneau P, Bujan L, Multigner L, Mieusset R (1998) Occupational heat exposure and male fertility: a review. Hum Reprod 13: 2122–2125

    PubMed  CAS  Google Scholar 

  • Toppari J, Larsen JC, Christiansen P, Giwercman A, Grandjean P, Guillette LJ, Jr., Jegou B, Jensen TK, Jouannet P, Keiding N, Leffers H, McLachlan JA, Meyer O, Muller J, Rajpert-De Meyts E, Scheike T, Sharpe R, Sumpter J, Skakkebaek NE (1996) Male reproductive health and environmental xenoestrogens. Environ Health Perspect 104 Suppl 4: 74 1803

    Google Scholar 

  • Trasler JM, Hales BF, Robaire B (1985) Paternal cyclophosphamide treatment of rats causes fetal loss and malformations without affecting male fertility. Nature 316x44–146

    Google Scholar 

  • Tsang AY, Lee WM, Wong PY (1981) Effects of antifertility drugs on epididymal protein secretion, acquisition of sperm surface proteins and fertility in male rats. Int J Androl 4: 703–712

    PubMed  CAS  Google Scholar 

  • Van Waeleghem K, De Clercq N, Vermeulen L, Schoonjans F, Comhaire F (1996) Deterioration of sperm quality in young healthy Belgian men. Hum Reprod 11:325–329

    Google Scholar 

  • Vierula M, Niemi M, Keiski A, Saaranen M, Saarikoski S, Suominen J (1996) High and unchanged sperm counts of Finnish men. Int J Androl 19: 11–17

    PubMed  CAS  Google Scholar 

  • Vogt HJ, Heller WD, Obe G (1984) Spermatogenesis in smokers and non-smokers: an andrological and genetic study. In: Obe G (ed) Mutation in man. Springer, Berlin Heidelberg New York, pp 247–291

    Google Scholar 

  • Walker C, Ahmed SA, Brown T, Ho SM, Hodges L, Lucier G, Russo J, Weigel N, Weise T, Vandenbergh J (1999) Species, inter-individual, and tissue specificity in endocrine signaling. Environ Health Perspect 107: 619–624

    Google Scholar 

  • Wang C, McDonald V, Leung A, Superlano L, Berman N, Hull L, Swerdloff RS (1997) Effect of increased scrotal temperature on sperm production in normal men. Fertil Steril 68: 334–339

    PubMed  CAS  Google Scholar 

  • Welch LS, Schrader SM, Turner TW, Cullen MR (1988) Effects of exposure to ethylene glycol ethers on shipyard painters: II. Male reproduction. Am J Ind Med 14: 509–526

    Google Scholar 

  • Whorton D, Krauss RM, Marshall S, Milby TH (1977) Infertility in male pesticide workers. Lancet 2: 1259–1261

    PubMed  CAS  Google Scholar 

  • Wilcox AJ, Baird DD, Weinberg CR, Hornsby PP, Herbst AL (1995) Fertility in men exposed prenatally to diethylstilbestrol. N Engl J Med 332: 1411–1416

    Google Scholar 

  • Wilton LJ, Temple-Smith PD, Baker HW, de Kretser DM (1988) Human infertility caused by degeneration and death of sperm in the epididymis. Fertil Steril 49x052–1058

    Google Scholar 

  • World Health Organization (1999) WHO Laboratory Handbook for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. Cambridge University Press, Cambridge New York Melbourne

    Google Scholar 

  • Xuezhi J, Youxin L, Yilan W (1992) Studies of lead exposure on reproductive system: a review of work in China. Biomed Environ Sci 5: 266–275

    PubMed  CAS  Google Scholar 

  • Yin Y, Stahl BC, DeWolf WC, Morgentaler A (1998) p53-mediated germ cell quality control in spermatogenesis. Dev Biol 204: 165–171

    Google Scholar 

  • Zenzes MT, Puy LA, Bielecki R, Reed TE (1999) Detection of benzo[a]pyrene diol epoxide-DNA adducts in embryos from smoking couples: evidence for transmission by spermatozoa. Mol Hum Reprod 5: 125–131

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Brinkworth, M.H., Handelsman, D.J. (2000). Umwelt- und arbeitsplatzbedingte Einflüsse auf die männliche Fertilität. In: Nieschlag, E., Behre, H.M. (eds) Andrologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05739-1_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-05739-1_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-05740-7

  • Online ISBN: 978-3-662-05739-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics