Zusammenfassung
Obwohl der Verdacht auf das Vorliegen einer altersabhängigen Makuladegeneration zunächst anhand von Anamnese und funduskopischer Untersuchung des Patienten erhoben werden kann, stellt die Fluoreszenzangiographie das derzeit wichtigste Instrument für eine präzise Diagnosestellung, nähere Charakterisierung und das Monitoring von Therapieeffekten dar. Zwei Fluoreszenzfarbstoffe kommen hierfür in der Augenheilkunde zur Anwendung: Fluoreszein, welches hauptsächlich für die retinale Angiographie verwendet wird, und Indozyaningrün, das in der choroidalen Angiographie zum Einsatz kommt (Spaide 1999; Tittl et al. 1999). Die Fluoreszeinangiographie wurde viel früher entwickelt, und so liegen weiterreichende Erfahrungen hinsichtlich der Korrelation zwischen fluoreszeinangiographischen Befunden und Histopathologie vor.Anwendung und Aussagekraft der Indozyaningrün-(ICG-)Angiographie sind mit der technologischen Entwicklung der bildgebenden Systeme seit einigen Jahren verbessert worden, allerdings bestehen noch Unklarheiten hinsichtlich der Relevanz der gewonnenen Befunde. Dennoch hat die Indozyaningrün-Angiographie vielfältige neue Einsichten in die Pathophysiologie verschiedener Typen choroidaler Neovaskularisationen ermöglicht.
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Literatur
Arnold JJ, Quaranta M, Soubrane G et al. (1997) Indocyanine green angiography of drusen. Am J Ophthalmol 124: 344–356
Fineman MS, Maguire JI, Fineman SW, Benson WE (2001) Safety of indocyanine green angiography during pregnancy: a survey of the retina, macula,and vitreous societies.Arch Ophthalmol 119: 353–355
Fox IJ,Wood EH (1957) Application of dilution curves recorded from the right side of the heart or venous circulation with the aid of a new indicator dye. Proc Mayo Clin 32: 541
Hartnett ME, Weiter JJ, Staurenghi G, Elsner AE (1996) Deep retinal vascular anomalous complexes in advanced age-related macular degeneration. Ophthalmology 103: 2042–2053
Holz FG, Bellmann C, Rohrschneider K et al. (1998) Simultaneous confocal scanning laser fluorescein and indocyanine green angiography. Am J Ophthalmol 125: 227–236
Holz FG, Bellmann C, Margaritidis M et aí. (1999) Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 237: 145–152
Hope-Ross M,Yannuzzi LA, Gragoudas ES et. al. (1994) Adverse reactions due to indocyanine green. Ophthalmology 101: 529–533
Kwiterovich KA, Maguire MG, Murphy RP et al. (1991) Frequency of adverse systemic reactions after fluorescein angiography. Results of a prospective study. Ophthalmology 98: 1139–1142
Macular Photocoagulation Study Group (1991) Subfoveal neovascular lesions in age-related macular degeneration. Guidelines for evaluation and treatment in the macular photocoagulation study. Arch Ophthalmol 109: 1217–1218
Obana A,MikiT,Hayashi Ket aí. (1994) Survey of complications of indocyanine green angiography in Japan. Am J Ophthalmol 118: 749–753
Pauleikhoff D, Zuels S, Sheraidah GS et. al. (1992) Correlation between biochemical composition and fluorescein binding of deposits in Bruch’s membrane. Ophthalmology 99: 1548–1553
PhotodynamicTherapy Study Group (2001) Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration:two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization — verteporfin in photodynamic therapy report 2. Verteporfin In Photodynamic Therapy Study Group. Am J Ophthalmol 131: 54160
Schmidt-Erfurth U, Michels S, Barbazetto I, Laqua H (2002) Photodynamic effects on choroidal neovascularization and physiological choroid. Invest Ophthalmol Vis Sci 43: 830–841
Slakter JS,Yannuzzi LA, Schneider U et al. (2000) Retinal choroidal anastomoses and occult choroidal neovascularization in age-related macular degeneration. Ophthalmology 107: 742–753
Spaide RF (1999) Fluorescein angiography. In: Spaide RF (ed) Diseases of the retina and vitreous. Saunders, Philadelphia, pp 29–38
Spaide RF (2003) Fundus autofluorescence and age-related macular degeneration. Ophthalmology 110: 392–399
Spaide RF,Yannuzzi LA, Sperber D, Sugin S, Slakter L, Orlach DA (1995) Indocyanine green videoangiography in idiopathic polypoidal choroidal vasculopathy. Retina 15: 100–110
Spaide RF, Hall L, Haas A et al. (1996) Indocyanine green videoangiography of older adults with central serous chorioretinopathy. Retina 16: 203–213
Spaide, RF, Donsoff I, Lam DL et al. (2002) Treatment of polypoidal choroidal vasculopathy with photodynamic therapy. Retina 22: 529–535
Tittl MK, Slakter JS, Spaide RF, Sorenson J,Guyer D (1999) Indocyanine green videoangiography.In:Spaide RF (ed) Diseases of the retina and vitreous.Saunders,Philadelphia, pp 39–46
Treatment of age-related macular degeneration with photo-dynamic therapy (TAP) study group (1999) Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin. One-year results of 2 randomized clinical trial-TAP report 1. Arch Ophthalmol 117: 1329–1345
Yannuzzi LA, Rohrer KT,Tindel LJ et al. (1986) Fluorescein angiography complication survey. Ophthalmology 93: 611–617
Yannuzzi LA, Negrao S, Iida T et al. (2001) Retinal angiomatous proliferation in age-related macular degeneration. Retina 21: 416–434
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Spaide, R.F., Eter, N. (2004). Fluoreszenzangiographie bei altersabhängiger Makuladegeneration. In: Altersabhängige Makuladegeneration. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05681-3_6
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DOI: https://doi.org/10.1007/978-3-662-05681-3_6
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