Skip to main content
SpringerLink
Log in

Alkohol und Niere

  • Chapter
Alkohol und Alkoholfolgekrankheiten

  • 402 Accesses

Zusammenfassung

Die Rolle des Alkohols für die Entstehung chronischer Nierenerkrankungen war bereits im 19. Jahrhundert bekannt, geriet jedoch in Vergessenheit und erregte erst in jüngster Zeit wieder größere Aufmerksamkeit. Alkoholkonsum führt zu morphologischen Veränderungen an der Niere, spezifisch im Rahmen des Syndroms der Alkoholembryopathie, subtil auch beim Erwachsenen mit Alkoholismus. Einige renal relevante Parameter sind eindeutig bei chronischem Alkoholismus verändert, z. B. kommt es zum gehäuften Auftreten von Hypertonie, Hyperurikämie mit chronischer Gicht, Elektrolytstörungen (die wichtigsten sind Hyponatriämie und Wasserintoxikation, Hypomagnesiämie, Hypokaliämie, Hypophosphatämie-Syndrom). Einem alkoholbedingten akuten Nierenversagen liegt am häufigsten Rhabdomyolyse, seltener Pankreatitis oder Hypophosphatämie zugrunde. Bei chronischem Alkoholismus sind generell alle Arten von chronischer Glomerulonephritis häufiger. Typisch ist die Häufung der mesangialen IgA-Glomerulonephritis sowie das häufigere Auftreten der postinfektiösen Glomerulonephritis mit ungünstigerer renaler Funktionsprognose.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Adams G, Jordan C (1984) Infections in the alcoholic. Med Clin N Am 68: 179–86

    PubMed  CAS  Google Scholar 

  • Allen AC, Topham PS, Harper SJ, Feehally J (1997) Leucocyte beta 1,3 galactosystransferase activity in IgA nephropathy. NDT 12 (4): 701–6

    Article  PubMed  CAS  Google Scholar 

  • Altura BM, Altura BT (1982) Microvascular and vascular smooth muscle actions of ethanol, acetaldehyde and acetate. Fed Proc 41: 2447–51

    PubMed  CAS  Google Scholar 

  • Bagasara O, Howeedy A, Doriao R (1987) Functional analysis of T cell subsets in chronic experimental alcoholism. Immunology 61: 63–70

    Google Scholar 

  • Baurd JD, Knott DH (1971) The effect of alcohol on fluid and electrolyte metabolism. In: Kissin B, Begleiter H (eds) The Biochemistry of Alcoholism. Vol 1. Plenum Press, London, pp 353–374

    Google Scholar 

  • Berger J, Yaneva H, Nabarra B (1978) Glomerular changes in pahtients with cirrhosis of the liver. Adv Nephrol 7: 3–14

    Google Scholar 

  • Bergmann MC, Klee MR, Faber DS (1972) Different sensitivities to ethanol of three early transvoltage clamp currents of aplasia neuraons. Pflug Arch Ges Physiol 348: 139–53

    Article  Google Scholar 

  • Boggan WO, Randall CM, Debeukelaer M, Smith R (1979) Renal anomalies in mice prenatally exposed to ethanol. Res Commun Chem Pathol Pharmacol 23 (1): 127–42

    PubMed  CAS  Google Scholar 

  • Bright R (1831) Reports of medical cases selected with a view of illustrating the symptoms and cure of diseases by a reference to morbid anatomy. In: Longman, Rees, Orne, Brown, Greene (eds) Natural history of diseases. London

    Google Scholar 

  • Brown NA, Goulding EH, Fabro S (1979) Ethanol embryotoxicity: Direct effects on mammalian embryos in vitro. Science 208: 573–5

    Google Scholar 

  • Callard P, Feldmann G, Prandi D et al. (1975) Immune complex type glomerulonephritis in cirrhosis of the liver. Am J Pathol 8o: 329–39

    Google Scholar 

  • Christison R (1829) On the granular degeneration of the kidney. Edin Med J 32: 262

    Google Scholar 

  • deMarchi S, Cecchin E, Grimaldi F, Basile A, Dell’Anna L, Tesio F 1985. Reversible tubular dysfunction in alcohol abuse. Proc Eur Dial Transplant Assoc Eur Ren Assoc 21: 866–74

    CAS  Google Scholar 

  • Eckhardt MJ, Hartford TC, Kaelber CT (1981) Health hazards associated with alcohol consumption. JAMA 246: 648–57

    Article  Google Scholar 

  • Eisenhofer G, Lambie D, Johnson R (1983) Effects of ethanol on plasma catecholamines and norepinephrine clearance. Clin Pharmacol Ther 34: 143–47

    Article  PubMed  CAS  Google Scholar 

  • Frerichs FT (1851) Die Brightsche Nierenerkrankung und deren Behandlung. Verlag Friedrich Vieweg, Braunschweig

    Google Scholar 

  • Friedman GD, Klatsky AL, Siegelaub AB (1982) Alcohol, tobacco and hypertension. Hypertension 4 (Supp13): 143–150

    Google Scholar 

  • Galante D, Adeana A, Perna P (1982) Decreased phagocytic and bactericidal activity of the hepatic reticuloendothelial system during chronic ethanol treatment and ist restoration by levamisole. J Reticuloendothel Soc 32: 179–85

    PubMed  CAS  Google Scholar 

  • Gleichmann L, Harburg E (1986) Alcohol usage and blood pressure (a review). Hum Biol 58: 1–31

    Google Scholar 

  • Goldfinger ST, Klinenberg JR, Seegmiller JE (1965) Renal retention of uric acid induced by infusion of betahydroxy-butyrate and acetoacetate. New Engl J Med 272: 351–55

    Article  PubMed  CAS  Google Scholar 

  • Hed R, Larsson H, Wahlgreen F (1955) Acute myoglobinuria. Report of a case with fatal outcome. Acta Med Scand 152: 459

    Google Scholar 

  • Hed T, Lundmark C, Fahlgreen H, Drell S (1962) Acute muscular syndrom in chronic alcoholism. Acta Med Scand 171: 585–589

    Article  PubMed  CAS  Google Scholar 

  • Helderman JH, Vestal RE, Rowe JW, Tobin JD, Andres R, Robertson GL (1978) The response of arginine vasopressin to intravenous ethanol and hypertonic saline in man: the impact of aging. J Gerontol 33 (1): 39–47

    Article  PubMed  CAS  Google Scholar 

  • Hilden P, Svendsen DL (1975) Electrolyte disturbances in beer drinkers: a specific »hypoosmolality syndrome«. Lancet 2: 245–6

    Article  PubMed  CAS  Google Scholar 

  • Howes JB, Ryan J, Fairbrother G, O’Neill K, Howes LG (1997) Alcohol consumption and blood pressure in recently hospitalized patients. Blood Pressure 6 /2: 109–111

    Article  PubMed  CAS  Google Scholar 

  • Jerrells T, Peritt D, Marietta C (1989) Mechanisms of suppression of cellular immunity induced by ethanol. Alcohol Clin Exp Res 53: 490–499

    Article  Google Scholar 

  • Jordö L, Olsson R, Zettergren P (1975) Effects of longterm administration of alcoholic beverages on the kidney, heart, skeletal muscle and pancreas of rats. J Stud Alcohol 36: 1131–8

    PubMed  Google Scholar 

  • Kalbfleisch JM, Lindeman rD, Ginn HE (1963) The effects of ethanol administration on urinary excretion of magnesium and other electrolytes in alcoholic and normal subjects. J Clin Invest 42: 1471–75

    Article  PubMed  CAS  Google Scholar 

  • Keil U, Chambless L, Filipak B, Härtel U (1991) Alcohol and blood pressure and its interaction with smoking and other behavioural variables: Results from the MONICA Augsburg Survey 1985–85. J Hypertension 9: 491–98

    Article  CAS  Google Scholar 

  • Keller CK, Andrassy K, Waldherr R, Ritz E (1994) Postinfectious glomerulonephritis–is there a link to alcoholism ? Quart J Med 87: 97–102

    PubMed  CAS  Google Scholar 

  • Knochel JP (1981) Renal disease, water and electrolyte metabolism in the alcoholic. In: Suki WN, Eknoyan G (eds) The Kidney in Systemic Disease. John Wiley, New York, pp 347–52

    Google Scholar 

  • Knochel JP, Schleim EM (1972) On the mechanisms of rhab- domyolysis in potassium depletion. J Clin Invest 51: 242–45

    Article  PubMed  CAS  Google Scholar 

  • Knochel JP, Osborn JR, Cooper EB (1965) Excretion of aldosterone in inappropriate secretion of antidiuretic hormone following headtrauma. Metabolism 14: 715–25

    Article  PubMed  CAS  Google Scholar 

  • Knochel JP, Cohen M, Anderson R (1976) Muscle comosition in alcoholic myopathy. Clin Res 24: 589 A

    Google Scholar 

  • Köhler H (1985) Alkohol und IgA in der Niere. Klin Wochenschr 63: 959–66

    Article  PubMed  Google Scholar 

  • Kreusser WJ, Ritz E, Boland R (1980) Phosphat-Depletion. Klin Wochenschr 58 (1): 1–15

    Article  PubMed  CAS  Google Scholar 

  • Lancereaux E (1865) Dictionnaire Encyclopedique des Sciences Médicales XXXVI. Alcoolisme. Masson, Paris, p 615–704

    Google Scholar 

  • Le J, Vilcek J (1987) Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities. Lab Invest 56: 234–239

    PubMed  CAS  Google Scholar 

  • Lesavre PH, Digeon M, Bach JF (1982) Analysis of circulation IgA and detection of immune complexes in primary IgA nephropathy. Clin Exp Immunol 48: 61–69

    PubMed  CAS  Google Scholar 

  • Lian C (1915) Alcoholism causes arterial hypertension (in French). Bull Acad Natl Med 74: 525–28

    Google Scholar 

  • Lieber CS, Jones DP, Losowsky MS, Davidson CS (1962) Interrelation of uric acid and ethanol in man. J Clin Invest 41: 1863–70

    Article  PubMed  CAS  Google Scholar 

  • MacGregor RR (1986) Alcohol and immune defense. JAMA 256: 1474–79

    Article  PubMed  CAS  Google Scholar 

  • Majewski F (1981) Alcohol embryopathy: Some factors and speculations about pathogenensis. Neurobehavioral Toxicol Teratol 3: 129–44

    CAS  Google Scholar 

  • McCollister RJ, Flink EB, Doe RP (1960) Magnesium balance studies in chronic alcoholism. J Lab Clin Med 55: 98–104

    CAS  Google Scholar 

  • McLeod AM (1977) Beer. In: Rose AH (ed) Alcoholic beverages. Academic Press, London, pp 43–137

    Google Scholar 

  • Mendelson JH, Gata MO, Mello NK (1969) Effects of alcohol ingestion and withdrawal on magnesium states of alcoholics: Clinical and experimental findings. Ann NY Acad Sci 162: 918–924

    Google Scholar 

  • Montseny JJ, Meyrier A, Kleinknecht D, Callard P (1995) The current spectrum of infectious glomerulonephritis. Experience with 76 patients and review of the literature. Med Baltimore 74 (2): 63–73

    Article  CAS  Google Scholar 

  • Mubarak S, Owen CA (1975) Compartmental syndrom and its relation to the crush-syndrome: A spectrum of disease. Clin Orthop 113: 81–85

    Google Scholar 

  • Mufti S, Prabhala R, Moriguchi S, Sipes I, Watson R (1988) Functional and numerical alterations induced by ethanol in the cellular immune system. Immunopharmacology 15: 82–92

    Article  Google Scholar 

  • Nakamoto Y, Iida H, Kobayashi K, Dohi K, Kida G, Hattori N, Takeuchi J (1981) Hepatic glomerulonephritis. Virchows Arch 392: 45–54

    CAS  Google Scholar 

  • Nickeleit V, Mihatsch MJ (1997) Uric acid nephropathy and end-stage renal disease–review of a non-disease. NDT 12 (9): 1832–8

    Article  PubMed  CAS  Google Scholar 

  • Osler W (1914) Diseases of the kidney. In: McCrae T, Osler W: The principles and practice of medicine. D. Appleton, New York London

    Google Scholar 

  • Pennington SM, Smith CP, Strider JB (1979) Alterations in prostaglandin catabolism in rats chronically dosed with ethanol. Biochemical Medicine 21: 246–52

    Article  PubMed  CAS  Google Scholar 

  • Percy M (1865) D’ivresse convulsive. Dictionnaire des Sciences Médicales XXXVI. Alcoolisme. Masson, Paris, p 249

    Google Scholar 

  • Potter J, Beevers D (1984) Pressor effect of alcohol in hypertension Lancet 1: 119–22

    CAS  Google Scholar 

  • Rambausek MH, Waldherr R, Ritz E (1993) Immunogenetic findings in glomerulonephritis. Kidney Int Suppl 39: S3–8

    PubMed  CAS  Google Scholar 

  • Rayer P (1844) Traité des maladies des reins et des alterations de la secretion urinaire. Paris

    Google Scholar 

  • Rimland D (1983) Mechanisms of ethanol-induced defects of alveolar macrophage function. Alcoholism 8: 73–80

    Google Scholar 

  • Ritz E (1982) Acute hypophosphatemia. Kidney Int 22 (1): 84–94

    Article  PubMed  CAS  Google Scholar 

  • Rubini ME, Kleeman CR, Landing E (1955) Studies on alcohol diuresis. I. The effect of ehtyl alcohol ingestin on water, electrolyte and acid-base metabolism. J Clin Invest 34: 439–47

    Google Scholar 

  • Rumpf KW, Kaiser H, Mattaei D, Prange H, Goebel HH, Henning HV, Scheler F (1979) Akutes Nierenversagen bei Alkohol-myopathie. Dtsch Med Wschr 104: 736–42

    Article  PubMed  CAS  Google Scholar 

  • Rünzi M, Layer P (1997) Ätiologie, Pathogenese und Pathophysiologie der akuten Pankreatitis. Schweiz Med Wochenschr. 127: 849–53

    Google Scholar 

  • Ryback RS, Eckardt MJ, Pautier CP (1980) Clinical relationships between serum phosphorus and other blood chemistry values in alcoholics. Arch Intern Med 140 (5): 673–77

    Article  PubMed  CAS  Google Scholar 

  • Salaspuro M (1992) Alcoholic liver disease. In: Prieto J, Rodés J, Shafritz DA (eds). Hepatobiliary Diseases. Springer, Berlin Heidelberg New York, pp 729–56

    Chapter  Google Scholar 

  • Salaspuro M, Lindros K (1985) Metabolism and toxicity of acetaldehyde. In: Seitz HK, Kommerell B (eds) Alcohol related diseases in gastroenterology. Springer, Berlin Heidelberg New York, PP 106–134

    Chapter  Google Scholar 

  • Saltissi D, Partrey PS, Cartis JR et al. (1984) Rhabdomyolysis and acute renal failure in chronic alcoholics with myopathy, unrelated to acute alcohol ingestion. Clin Neprhol 21: 294–300

    CAS  Google Scholar 

  • Sancho J, Egido J, Sanchez-Crespo M, Blasco R (1981) Detection of monomeric and polymeric IgA containing immune complexes in serum and kidney from patients with alcoholic liver disease. Clin Exp Immunol 47: 327–35

    Google Scholar 

  • Sargent WR, Simpson JR, Beard (1975) Renal hemodynamics and electrolyte excretions after reserpine and ethanol. J Pharmacol exp Ther 193: 356–362

    CAS  Google Scholar 

  • Sargent WQ, Simpson JR, Beard JD (1980) Twenty-four hour fluid intake and renal handling of electrolytes after various doses of ethanol. Alcoholism (NY) 4 (1): 74–83

    Article  CAS  Google Scholar 

  • Seeman P, Chau M, Goldberg M, Sauks T, Sax L (1971) The binding of Cat’ to the cell membrane is increased by bolatile anethetics (alcohols, acetone, ether) which induce sensitization of nerve or muscle. Biochim Biophys Acta 225: 185–93

    Article  PubMed  CAS  Google Scholar 

  • Senator H (1896) Die Erkrankungen der Nieren. Alfred Hölder, Wien, S 209 ff

    Google Scholar 

  • Spagnuaolo RJ, MacGregor RR (1975) Acute ethanol effect on chemotaxis and other components of host defense. J Lab Clin Med 86: 24–29

    Google Scholar 

  • Stein JH, Smith WO, Ginn HE (1966) Hypophosphatemia in acute alcoholism. Am J Med Sci 252: 76–83

    Article  Google Scholar 

  • Thiel DH van, Gavaler JS, Little JM, Lester R (1979) Alcohol: its effect on the kidney. Adv Exp Med Biol 85a: 449–57

    Google Scholar 

  • Tran DD, Oe PL, de Fijter CW, van der Meulen J, Cuesta MA (1997) Acute renal failure in pathients with acute pancreatitis: prevalence, risk factors and outcome. NDT 8 (10): 1079–84

    Google Scholar 

  • Triboulet H, Mathieu F (1900) L’alcool et l’alcoolisme. Notions générales, Toxicologie et Physiologie, Pathologie, Thérapeutique, Prophylaxie. Appleton, London Paris, p 129–145

    Google Scholar 

  • Waldherr R, Rambausek M, Duncker WD, Ritz E (1989) Frequency of mesangial IgA deposits in a non-selected autopsy series. NDT 4 (11): 943–946

    PubMed  CAS  Google Scholar 

  • Yamanaka H (1996) Alxohol ingestion and hyperuricemia. Nippon Rinsho 54 (12): 3369–73

    PubMed  CAS  Google Scholar 

  • Zawada ET, Johnson M, Sica D (1985) Ethanol-induced water diu- resis is not prostaglandin dependent. Nephron 40: 149–51

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Christine K. Keller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eberhard Ritz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. IV. Medizinische Universitätsklinik (Schwerpunkt Gastroenterologie und Hepatologie), Fakultät für Klinische Medizin Mannheim, Universität Heidelberg, Universitätsklinikum Mannheim, Theodor-Kutzer-Ufer 1-3, D-68167, Mannheim, Deutschland

    Manfred V. Singer  & Stephan Teyssen  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Keller, C.K., Ritz, E. (1999). Alkohol und Niere. In: Singer, M.V., Teyssen, S. (eds) Alkohol und Alkoholfolgekrankheiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05657-8_27

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-05657-8_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-05658-5

  • Online ISBN: 978-3-662-05657-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation