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Neurobiologische Grundlagen psychiatrischer Erkrankungen

  • R. Dorow

Zusammenfassung

Die Erforschung des ZNS ist eine der großen Herausforderungen der modernen Wissenschaften. Seit der Mensch annimmt, daß die Seele im Gehirn residiert, begann die wissenschaftliche Suche nach den biologischen Grundlagen des Bewußtseins und den mentalen Funktionen z.B. des Lernens und Gedächtnisses. Fragen nach der Lokalisation von Gefühlen und dem Gedächtnis gehören dazu. Welche Gesetze gelten für spezifische Funktionen und können sie besser verstanden werden, wenn man die Gesamtregion oder einzelne Nervenzellen untersucht? Die zentrale These der modernen Neurowissenschaften geht davon aus, daß alles Verhalten durch bestimmte Hirnfunktionen erklärbar ist. Daraus folgt, daß Störungen des Affekts und des Denkens auf Störungen der Hirnfunktion zurückzuführen sein müßten.

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Literatur

  1. Adrian ED (1932) The mechanism of nervous action: electrical studies of the neurone. University of Pennsylvania Press, PhiladelphiaGoogle Scholar
  2. Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD (1989) Molecular biology of the cell, 2nd ed. Garland, New YorkGoogle Scholar
  3. Benkert O, Hippius H (1986) Psychiatrische Pharmakotherapie. Springer, Berlin Heidelberg New YorkCrossRefGoogle Scholar
  4. Bennet MVL, Barrio LC, Bargiello TA, Spray DC, Hertzberg E, Sdez JC (1991) Gap junctions: new tools, new answers, new questions. Neuron 6: 305–320CrossRefGoogle Scholar
  5. Björklund A, Hökfelt T (1984) Handbook of chemical neuroanatomy, vol. 2 + 3. Elsevier, AmsterdamGoogle Scholar
  6. Catteral WA (1988) Structure and function of voltage-sensitive ion channels. Science 242: 50–61CrossRefGoogle Scholar
  7. Cooper JR, Bloom FE, Roth RH (1991) The biochemical basis of neuropharmacology 6th ed. Oxford University Press, New YorkGoogle Scholar
  8. Eccles JC (1976) From electrical to chemical transmission in the central nervous system. The closing address of the Sir Henry Dale Centennial Symposium. Notes Rec R Soc Lond 30: 219–230PubMedCrossRefGoogle Scholar
  9. Eccles JC (1990) Das Gehirn des Menschen. Piper Verlag, MünchenGoogle Scholar
  10. Ehrlich P (1913) Chemotherapeutics: scientific principles, methods and results. Lancet II: 445–451Google Scholar
  11. Finkelstein A, Mauro A (1977) Physical principles and formalisms of electrical excitability. In: Kandel ER (ed) Handbook of Physiology, Section I: The Nervous System, vol. I. Cellular Biology of Neurons, part I. Bethesda, Md.: American Physiological Society, pp 161–213Google Scholar
  12. Gold PW, Goodwin FK, Chrousos GP (1988) Clinical and biochemical manifestations of depression (parts I and II). New Engl J Med 319: 348–353PubMedCrossRefGoogle Scholar
  13. Gold PW, Goodwin FK, Chrousos GP (1988) Clinical and biochemical manifestations of depression (parts I and II). New Engl J Med 319: 413–420PubMedCrossRefGoogle Scholar
  14. Hille B (1984) Ionic channels of excitable membranes. Sinauer, Sunderland, Massachusetts Kandel ER, Schwartz JH, Jessell TM (1991) Principles of Neural Science, 3rd ed. Elsevier, New YorkGoogle Scholar
  15. Katz B (1969) The release of neural transmitter substances. Thomas, Springfield, IllinoisGoogle Scholar
  16. Kebabian JW, Caine DB (1979) Multiple receptors for dopamine. Nature (London) 277: 93–96CrossRefGoogle Scholar
  17. Kelly RB (1988) The cell biology of the nerve terminal. Neuron 1: 431–438PubMedCrossRefGoogle Scholar
  18. Koob GF, Sandman CA, Strand FL (eds) (1990) A decade of neuropeptides: past, present and future. Ann NY Acad Sci 579: 1–281Google Scholar
  19. Kuffler SW, Niccolls JG, Martin AR (1984) From neuron to brain: a cellular approach to the function of the nervous system, 2nd ed. Sinauer, Sunderland, MassachusettsGoogle Scholar
  20. Langley JN (1906) On nerve endings and special excitable substances in cells. Proc R Soc London Ser B 78: 170–194CrossRefGoogle Scholar
  21. Martin JB, Brownstein MJ, Krieger DT (eds) (1987) Brain peptides update, vol 1. Wiley, New YorkGoogle Scholar
  22. Meltzer HT (1987) Psychopharmacology: the third generation of progress. Raven Press, New YorkGoogle Scholar
  23. Miller C (1987) How ion channel proteins work. In: Kaczmarek LK, Levitan IB (eds) Neuromodulation: the biological control of neuronal excitability. Oxford University Press, New York, pp 39–63Google Scholar
  24. Peters A, Palay SL, Webster H (1991) The fine structure of the nervous system: neurons and their supporting cells, 3rd ed. Oxford University Press, New YorkGoogle Scholar
  25. Ramón y Cajal S (1906) The structure and connexions of neurons. In: Nobel lectures: physiology & medicine 1907–1921. Elsevier, Amsterdam, pp 220–253Google Scholar
  26. Riederer P, Laux G, Pöldinger W (1992) Neuropsychopharmaka. Ein Therapie Handbuch, bd 4–6, Springer, WienCrossRefGoogle Scholar
  27. Schildkraut JJ (1965) The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiat 122: 509–522PubMedGoogle Scholar
  28. Sakmann B, Neher E (eds) (1983) Single-channel recording. Plenum Press, New YorkGoogle Scholar
  29. Seeman P, Lee T, Chau-Wong M, Wong K (1976) Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature 261: 717–719PubMedCrossRefGoogle Scholar
  30. Siegel GJ, Agranoff BW, Albers RW, Molinoff PB (eds) (1989) Basic Neurochemistry: molecular, cellular, and medical aspects, 4th ed. Raven Press, New YorkGoogle Scholar
  31. Snyder SH (1984) Drug and neurotransmitter receptors in the brain. Science 224: 22–31PubMedCrossRefGoogle Scholar
  32. Stevens CF (1991) Ion channels: making a submicroscopic hole in one. Nature 349: 657–658PubMedCrossRefGoogle Scholar
  33. Unwin PNT, Zampighi G (1980) Structure of the junction between communicating cells. Nature 283: 545–549PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1993

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  • R. Dorow

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