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Are Estrogens of Importance to Ovarian Function?

  • Conference paper
Book cover New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 46))

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Abstract

Locally produced estrogens interact with gonadotrophins to modulate the spatio-temporal expression of many genes necessary for follicular growth and ovulation. Rates of biosynthesis and metabolism and degree of estrogen receptivity via nuclear estrogen receptors (ER) are major determinants of estrogen action in target cells. This chapter reassesses these aspects of intraovarian estrogen signaling, as a basis for interpreting the ovarian phenotypes of rodents bearing targeted deletion of genes involved in estrogen synthesis and signaling. Its scope excludes species other than rodents and omits consideration of alternative modes of steroid action in the ovary via nongenomic mechanisms, which have recently been reviewed elsewhere (Palter et al. 2001).

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Authors
  1. S. G. Hillier
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K. S. Korach A. Hillisch K. H. Fritzemeier

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© 2004 Springer-Verlag Berlin Heidelberg

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Hillier, S.G. (2004). Are Estrogens of Importance to Ovarian Function?. In: Korach, K.S., Hillisch, A., Fritzemeier, K.H. (eds) New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy. Ernst Schering Research Foundation Workshop, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05386-7_8

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  • DOI: https://doi.org/10.1007/978-3-662-05386-7_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-05388-1

  • Online ISBN: 978-3-662-05386-7

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