Biginelli pyrimidone synthesis

  • Jie Jack Li


One-pot condensation of an aromatic aldehyde, urea, and ethyl acetoacetate in acidic ethanolic solution and expansion of such a condensation thereof.


Inorganic Chemistry Organic Chemistry Aromatic Aldehyde Ethanolic Solution Ethyl Acetoacetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Biginelli, P. Ber. Dtsch. Chem. Ges. 1891 24,1317.Google Scholar
  2. 2.
    Sweet, F.; Fissekis, J. D. J. Am. Chem. Soc. 1973, 95, 8741.CrossRefGoogle Scholar
  3. 3.
    Kappe, C. O. Tetrahedron 1993 49,6937. (Rev iew).Google Scholar
  4. 4.
    Kappe, C. O. Acc. Chem. Res. 2000, 33, 879. (Rev iew).Google Scholar
  5. 5.
    Kappe, C. O. Eur. J. Med. Chem. 2000, 35, 1043. (Rev iew).Google Scholar
  6. 6.
    Lu, J.; Bai, Y.; Wang, Z.; Yang, W.; Ma, H. Tetrahedron Lett. 2000, 41, 9075.CrossRefGoogle Scholar
  7. 7.
    Garcia Valverde, M.; Dallinger, D.; Kappe, C. O. Synlett 2001, 741.Google Scholar
  8. 8.
    Stadler, A.; Kappe, C. O. J. Comb. Chem. 2001, 3, 624.CrossRefGoogle Scholar
  9. 9.
    Rani, V. R.; Srinivas, N.; Kishan, M. R.; Kulkarni, S. J.; Raghavan, K. V. Green Chem. 2001, 3, 305.CrossRefGoogle Scholar
  10. 10.
    Lu, J.; Bai, Y. Synthesis 2002, 466.Google Scholar
  11. 11.
    Perez, R.; Beryozkina, T.; Zbruyev, O. I.; Haas, W.; Kappe, C. O. J. Comb. Chem. 2002, 4, 501.CrossRefGoogle Scholar
  12. 12.
    Varala, R.; Alam, M. M.; Adapa, S. R. Synlett 2003, 67.Google Scholar
  13. 13.
    Martinez, S.; Meseguer, M.; Casas, L.; Rodriguez, E.; Molins, E.; Moreno-Marsas, M.; Roig, A.; Sebastian, R. M.; Valribera, A. Tetrahedron 2003, 59, 1553.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Jie Jack Li
    • 1
  1. 1.Chemistry DepartmentPfizer Global Research and DevelopmentAnn ArborUSA

Personalised recommendations