Abstract
Protein-protein interfaces remain among the most challenging if not intractable targets for small-molecule drug discovery. Despite the wealth of structural information that has accumulated about these complexes and their tremendous value as biotherapeutics, little progress has been made toward identifying small molecules that can specifically target these interfaces. Here, I will review some of the progress we have made in targeting the cytokine receptor interfaces for drug discovery.
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Wells, J. et al. (2003). Drug Discovery at Signaling Interfaces. In: Waldmann, H., Koppitz, M. (eds) Small Molecule — Protein Interactions. Ernst Schering Research Foundation Workshop, vol 42. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05314-0_3
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DOI: https://doi.org/10.1007/978-3-662-05314-0_3
Publisher Name: Springer, Berlin, Heidelberg
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