Abstract
It was estimated that malignant tumors of the digestive system would be diagnosed in about 235,700 people in the United States in 2001, with approximately 131,300 related deaths [1]. In this chapter, cancers of the esophagus, stomach, pancreas, biliary tract, rectum, anal region and metastases to the liver will be discussed.
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O. Henry
Cupid a la Carte
Heart of the West
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References
Blot WJ, McLaughlin JK (1999) The changing epidemiology of esophageal cancer. Semin Oncol 26 [5 Suppl 151: 2–8
Blot WJ (1995) Epidemiology and genesis of esophageal cancer. In: Roth JA, Ruckdeschel JC, Weisenberger TA (eds) Thoracic oncology. Saunders, Philadelphia, pp 278–287
Raphael HA (1966) Primary carcinoma of the esophagus: 18 year review and a review of literature. Ann Surg 164: 785–796
Gunnlangsson GH (1970) Analysis of the records of 1657 patients with carcinoma of the esophagus and cardia of the stomach. Surg Gynecol Obstet 130: 997–1005
Begin LR (1995) The pathology of esophageal cancer. In: Roth JA, Ruckdeschel JC, Weisenberger TH (eds) Thoracic oncology. Saunders, Philadelphia, pp 288–335
Steiger Z, Wilson RF, Leichman L, Busuito MJ, Rosenberg JC (1987) Primary adenocarcinomas of the esophagus. J Surg Oncol 36: 68–70
Yang PC, Davis S (1988) Incidence of cancer of the esophagus in the United States by histologic type. Cancer 61: 612–617
American Joint Committee on Cancer (1992) Manual for staging of cancer, 5th edn. Lippincott, Philadelphia
Thompson WM (1983) Esophageal cancer. Int J Radiat Oncol Biol Phys 9: 1533–1565
Earlham R (1991) An MRC prospective randomized trial of radiotherapy versus surgery for operable squamous cell carcinoma of the esophagus. Ann R Coll Surg Eng 73: 8–12
Earlham R, Cunha-Melo JR (1980) Esophageal squamous cell carcinoma: a critical review of surgery. Int J Surg 67: 381–390
Pearson JG (1977) The present status and future potential of radiotherapy in the management of esophageal cancer. Cancer 39: 882–890
Mandard AM, Chasle J, Marnay J et al (1981) Autopsy findings in 111 cases of esophageal cancer. Cancer 48: 329–335
Coia LR (1994) The esophagus. In: Cox JD (ed) Moss’ radiation oncology: rationale, technique, results, 7th edn. Mosby, St Louis, pp 405–427
O’Rourke MB, Tiver K, Bull C et al (1988) Swallowing performance after radiation therapy for carcinoma of the esophagus. Cancer 61: 2022–2026
Caspers RJL, Welvaart K, Verkes RJ, Herman J, Leer JWH (1988) The effect of radiotherapy on dysphagia and survival in patients with esophageal cancer. Radiother Oncol 12: 15–23
Wara WM, Mauch PM, Thomas AN, Phillips T (1976) Palliation for carcinoma of the esophagus. Radiology 121: 717–720
Petrovich Z, Langholz B, Formenti S, Luxton G, Astrahan M (1991) Management of carcinoma of the esophagus: the role of radiotherapy. Am J Clin Oncol 14: 80–86
Brown SG (1991) Palliation of malignant dysphagia: surgery, radiotherapy, laser, intubation alone or in combination. Gut 32: 841–844
Herskovic A, Martz K, Al-Sarraf M (1992) Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Engl J Med 326: 1593–1598
Al-Sarraf M, Martz K, Herskovic A et al (1977) Progress report of combined chemoradiotherapy versus radiotherapy alone in patients with esophageal cancer: an intergroup study. J Clin Oncol 15: 277–284
Coia LR, Soffen EM, Schultheiss TE et al (1993) Swallowing function in patients with esophageal cancer treated with concurrent radiation and chemotherapy. Cancer 71: 281–286
Schrump DS, Altorki NS, Forastiere AA, Minsky BD (2001) Cancer of the esophagus. In: De Vita VT, Hellman S, Rosenberg SA (eds) Cancer: principles and practice of oncology, 6th edn. Lippincott-Raven, Philadelphia, pp 1051–1091
Gschossmann JM, Bonner JA, Foote RL et al (1993) Malignant tracheo-esohageal fistula in patients with esophageal cancer. Cancer 72: 1513–1521
Marcial VA, Tome JM, Ubinas J, Bosch A, Correa JN (1966) The role of radiation therapy in esophageal cancer. Radiology 87: 231–239
Arlington A, Bohorques J (1993) Irradiation of carcinoma of the esophagus containing a tracheoesophageal fistula. Cancer 71: 3808–3812
Burt M, Diehl W, Martini N (1991) Malignant esophagorespiratory fistula: management options and survival. Ann Thoracic Surg 52: 1222–1229
Sur RK, Donde B, Levin VC et al (1998) Fractionated high dose rate intraluminal brachytherapy in palliation of advanced esophageal cancer. Int J Radiat Oncol Biol Phys 40: 447–453
McCaughan JS, Nims TA, Guy JT et al (1989) Photodynamic therapy for esophageal tumors. Arch Surg 124: 74–80
Maier A, Tomaselli F, Gebhard F et al (2000) Palliation of advanced esophageal carcinoma by photodynamic therapy and irradiation. Ann Thorac Surg 69: 1006–1009
Norberto L, Rangato R, Marino S et al (1999) Endoscopic palliation of esophageal and cardiac cancers: neodymium -yttrium-aluminum-garnet laser therapy. Dis Esophagus 12: 294–296
Hayter CR, Huff-Winters C, Paszat L, Youssef YM, Shelley WE, Schultze K (2000) A prospective trial of short-course radiotherapy plus chemotherapy for palliation of dysphagia from advanced esophageal cancer. Radiother Oncol 56: 329–333
Orringer MB (1993) Multimodality therapy for esophageal carcinoma - update. Chest 103 [Suppl 4]: 406S - 4095
Griffin WO Jr, Daugherty ME, McGee EM, Utley JR (1976) Unified approach to carcinoma of the esophagus. Ann Surg 183: 511–516
Osborne MP, Griffiths JD, Shaw HJ (1982) Colon transposition in the management of upper gastrointestinal cancer. Cancer 50: 2235–2242
Kairaluoma MI, Jokinen K, Karkola P, Larmi TK (1977) Celestin tube palliation of unresectable esophageal carcinoma. J Thorac Cardiovasc Surg 73: 783–786
Cwikiel M, Cwikiel W, Albertson M (1996) Palliation of dysphagia in patients with malignant esophageal structures. Acta Oncol 35: 75–79
Konigsraiiner A, Riedmann B, DeVries A et al (2000) Expandable metal stents versus laser combined with radiotherapy for palliation of unresectable esophageal cancer: a prospective randomized trial. Hepatogastroenterology 47: 724–727
Bethge N, Sommer A, Vakil N (1998) Palliation of malignant esophageal obstruction due to intrinsic and extrinsic lesions with expandable metal stents. Am J Gastroenterol 93: 1829–1832
Bartelsman JF, Bruno MJ, Jensema AJ et al (2000) Palliation of patients with esophagogastric neoplasms by insertion of a covered expandable modified. Gianturco-Z endoprothesis: experiences in 153 patients. Gastrointest Endosc 51: 134–138
Munoz N, Franceschi S (1997) Epidemiology of gastric cancer and perspectives for prevention. Salud Publica Mex 39: 318–330
SEER Cancer Statistics Review 1973–1996
Weisburger JH, Marquardt H, Mower HF et al (1980) Inhibition of carcinogenesis: vitamin C and the prevention of gastric cancer. Prey Med 9: 352–361
Berkson J (1964) In: ReMine WHR (ed) Cancer of the stomach. Saunders, Philadelphia
Nishikubo C, Haskell CM (2001) Stomach: natural history, diagnosis, and staging of gastric cancer. In: Haskell CM (ed) Cancer treatment, 5th edn. Saunders, Philadelphia, pp 682–688
Japanese Research Society for Gastric Cancer (1981)The general rules for the gastric cancer study in surgery and pathology. Jpn J Surg 11:127–139
Longmire WB Jr (1977) Carcinoma of the stomach. In: Sabiston DC Jr (ed) Davis Christopher textbook of surgery. Saunders, Philadelphia
Tabbarah JH (1995) Gastrointestinal tract cancers. In: Casciato DA, Lowitz BB (eds) Manual of clinical oncology, 3rd edn. Little Brown, Boston, pp 150–165
Dupont BJ Jr, Cohn I Jr (1980) Gastric adenocarcinoma. Curr Probl Cancer 4: 1–46
Calvo FA, Martinez-Monge R, Ortiz de Urbina D, Gunderson LL (2000) Stomach cancer. In: Gunderson LL, Tepper E (eds) Clinical radiation oncology. Churchill Livingstone, Edinburgh, pp 652–686
Landry J, Tepper JE, Wood WC, Moulton EO, Koerner F, Sullinger J (1990) Patterns of failure following curative resection of gastric carcinoma. Int J Radiat Oncol Biol Phys 19: 1357–1362
Combs RC, Schein PS, Chilvers CS et al (1990) A randomized trial comparing adjuvant fluorouracil, doxorubicin and mitomycin with no treatment in operable gastric cancer. International Collaborative Cancer Group. J Clin Oncol 8: 1362–1369
Gagliano R, McCracken J, Chen T (1983) Adjuvant chemotherapy with FAM in gastric cancer: a SWOG study. Proc Am Soc Clin Oncol 2: 114–116
Hermans J, Bonnenkamp JJ, Boon MC et al (1993) Adjuvant therapy after curative resection for gastric cancer: meta-analysis of randomized trails. J Clin Oncol 11: 1441–1447
Minsky BD (1996) The role of radiation therapy in gastric cancers. Semin Oncol 23: 390–396
Wieland C, Hymmen U (1970) Megavoltage therapy for malignant stomach neoplasms. Strahlentherapie 140: 20–26
Takahashi M, Abe M (1986) Intraoperative radiotherapy for carcinoma of the stomach. Eur J Surg Oncol 12: 247–250
Avizonis VN, Buzydlowski J, Lanciano R et al (1995) Treatment of adenocarcinoma of the stomach with resection, intraoperative radiotherapy and adjuvant external beam radiation: a phase II study from Radiation Therapy Oncology Group 85–04. Ann Surg Oncol 2: 295–302
Smalley S, Benedetti J, Gunderson LL et al (2000) Intergroup 0116 (SWOG 9008) Phase III trial of postoperative adjuvant radiochemotherapy for high-risk gastric and gastro-esophageal junction adenocarcinoma: evaluation of efficacy and radiotherapy treatment planning. Report at the 42nd annual meeting of the American Society for Therapeutic Radiology and Oncology
Murad AM, Santiago FF, Petroianu A et al (1993) Modified therapy with 5-fluorouracil, doxorubicin and methotrexate in advanced gastric cancer. Cancer 72: 37–41
Pyrhonen S, Kuitunen T, Nyandoto P et al (1995) Randomized comparison of fluorouracil, epidoxorubicin and methotrexate ( FEMTX) plus supportive care with supportive care alone in patients with non-resectable gastric cancer. Br J Cancer 71: 587–591
Glimelius B, Ekstrom K, Hoffman K, Graf W, Sjoden PO, Haglund U, Svensson C, Enander LK, Linne T, Sellstrom H, Heuman R (1997) Randomized comparison between chemotherapy plus best supportive care in advanced gastric cancer. Ann Oncol 8: 163–168
Gunderson LL, Martenson JA Jr (1989) Gastrointestinal tract radiation tolerance. Front Radiat Ther Oncol 23: 277–298
Glimelius B, Ekstrom K, Hoffman K et al (1997) Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer. Ann Oncol 8: 163–168
Gunderson LL, Martenson JA Jr (1989) Gastrointestinal tract tolerance. Front Radiat Ther Oncol 23: 277–298
Landis SH, Murray T, Bolden S, Wingo PA (1999) Cancer statistics, 1999. CA Cancer J Clin 49: 8–31
SEER Cancer Statistics Review 1973–1996
Mack TM (1982) Pancreas. In: Schottenfeld D, Fraumeni J (eds) Cancer epidemiology and prevention. Saunders, Philadelphia, pp 638–667
Gudjonsson B (1987) Cancer of the pancreas, 50 years of surgery. Cancer 50: 2284–2303
Stevens KR (1994) The pancreas. In: Cox JD (ed) Moss’ radiation oncology, 7th edn. Mosby, St Louis, pp 440–451
Gunderson LL, Shipley WU, Kopelson G (1987) Pancreatic and hepatobiliary cancer. In: Perez CA, Brady LW (eds) Principles and practice of radiation oncology. Lippincott, Philadelphia
Cubilla AL, Fitzgerald PJ, Fortner JG (1978) Pancreatic cancer–duct cell adenocarcinoma: survival in relation to site, size, stage and type of therapy. J Surg Oncol 10: 465–482
Longmire WP, Traverso IW (1981) The Whipple procedure and other standard operative approaches to pancreatic cancer. Cancer 47: 1706–1711
Malt RA (1983) Treatment of pancreatic cancer. JAMA 250: 1433–1437
Beagley R (1981) Needle biopsy diagnosis of pancreatic cancer. Cancer 45: 1685–1687
Tepper J, Nardi GL, Suit HD (1976) Carcinoma of the pancreas - review of MGH experience from 1963 to 1973. Analysis of surgical failure and implications for radiation therapy. Cancer 37: 1519–1524
Gouma DJ, van Geenen R, van Gulik T et al (1999) Surgical palliative treatment in bilio-pancreatic malignancy. Ann Oncol 10: S269 - S272
Tan HP, Smith J, Garberoglio CA (1996) Pancreatic adenocarcinoma: an update. J Am Coll Surg 183: 164–184
Yeo CJ (1998) Pancreatic cancer: 1998 update. J Am Coll Surg 187: 429–442
Smith AC, Dowsett JF, Russell RCG et al (1994) Randomized trial of endoscopic stenting versus surgical bypass in malignant low bile duct obstruction. Lancet 344: 1655–1660
Raikar GV, Melin MM, Ress A et al (1996) Cost-effectiveness analysis of surgical palliation versus endoscopic stenting in the management of unresectable pancreatic carcinoma. Ann Surg Oncol 3: 470–475
Lillemoe KD, Cameron JL, Kaufman HS et al (1993) Chemical splanchnicectomy in patients with unresectable pancreatic cancer. A prospective randomized trial. Ann Surg 217: 447–457
Watanapa P, Williamson RC (1992) Surgical palliation for pancreatic cancer: developments during the past two decades. Br J Surg 79: 8–20
Wagensveld BA, Coene P, van Gulik TM et al (1997) Outcome of palliative biliary and gastric bypass surgery for pancreatic head carcinoma in 126 patients. Br J Surg 84: 1402–1406
Weaver DW, Wiencek RG, Bouwman DL et al (1987) Gastrojejunostomy: is it helpful for patients with pancreatic cancer? Surgery 102: 608–613
MacDonald JS, Gunderson LL, Cohn I (1982) Cancer of the pancreas. In: De Vita VT, Hellman S, Rosenberg SA (eds) Principles and practice of oncology. Lippincott, Philadelphia
Haslam JB, Cavanaugh PJ, Stroup SI (1973) Radiation therapy in the treatment of irresectable adenocarcinoma of the pancreas. Cancer 32: 1341–1345
Whittington R, Dobelbower RR, Mohiuddin M, Rosato FE, Weiss SM (1981) Radiotherapy of unresectable pancreatic carcinoma: a six-year experience with 104 patients. Int J Radiat Oncol Biol Phys 7: 1639–1644
Dobelbower RR Jr, Borgelt BB, Strubler KA, Kutcher GJ, Suntharalingam N (1980) Precision radiotherapy for cancer of the pancreas: technique and results. Int J Radiat Oncol Biol Phys 4: 1127–1133
Komaki R, Wilson JF, Cox JD, Kline RW (1980) Carcinoma of the pancreas: results of irradiation for unresectable lesions. Int J Radiat Oncol Biol Phys 6: 209–212
Tran LM (2001) Radiation therapy for cancers of the exocrine pancreas. In: Haskell CM (ed) Cancer treatment, 5th edn. Saunders, Philadelphia, pp 758–762
Gastrointestinal Tumor Study Group (1979) A multi-institutional comparative trial of radiation therapy alone and in combination with 5-FU for locally unresectable pancreatic cancer. Ann Surg 189: 205–208
Moertel CG, Frytak S, Hahn RG et al (1981) Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high-dose (6000 rads) radiation alone, moderate-dose radiation (4000 rads + 5-fluorouracil), and high-dose radiation plus 5-fluorouracil. The Gastrointestinal Tumor Study Group. Cancer 48: 1705–1710
Poen J, Collins H, Niederhuber J et al (1998) Chemo-radiotherapy for localized pancreatic cancer increased dose intensity and reduced acute toxicity with concomitant radiotherapy and protracted venous infusion 5-fluorouracil. Int J Radiat Oncol Biol Phys 40: 93–99
Andre T, Balosso J, Louvet C et al (2000) Combined radiotherapy and chemotherapy (cisplatin and 5-fluorouracil) as palliative treatment for localized unresectable or adjuvant treatment for resected pancreatic adenocarcinoma: results of a feasibility study. Int J Radiat Oncol Biol Phys 46: 903–911
Mohiuddin M, Rosato F, Barbot D et al (1992) Long-term results of combined modality treatment with iodine 125 implant for cancer of the pancreas. Int J Radiat Oncol Biol Phys 23: 305–311
Roldan GE, Gunderson LL, Nagorney DM et al (1988) External beam versus intraoperative and external beam irradiation for locally advanced pancreatic cancer. Caner 61: 110–116
Tepper JE, Noyes D, Krall JM et al (1991) Intraoperative radiation therapy of pancreatic carcinoma: a re port of RTOG-8505. Int J Radiat Oncol Biol Phys 21: 1145–1149
Garton GR, Gunderson LL, Nagorney DM et al (1993) High dose preoperative external beam and intraoperative irradiation for locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 27: 1153–1157
Burris HA, Moore MJ, Anderson J et al (1997) Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 15: 2403–2413
Rothenberg MI, Moore MJ, Cripps MC et al (1996) A phase II trial in patients with 5-FU fractory pancreas cancer. Ann Oncol 7: 347–353
SEER Cancer Statistics Review, 1973–1996
Haskell CM (2001) Gallbladder: natural history, diagnosis and staging in cancer treatment. In: Haskell CM (ed) Cancer treatment,5th edn. Saunders, Philadelphia, pp 786–788
Piehler JM, Cricklow RW (1978) Primary carcinoma of the gallbladder. Surg Gynecol Obstet 147: 929–942
Adson MA, Farnell MB (1981) Hepato-biliary cancer–surgical considerations. Mayo Clin Proc 56: 686–699
Blalock JB Jr (1978) An analysis of 15 cases of gallbladder carcinoma. Ann Surg 44: 286–289
Haskell CM, Tran LM, Ramming KP (2001) Gallbladder: treatment. In: Haskell CM (ed) Cancer treatment, 5th edn. Saunders, Philadelphia, pp 789–790
Vaittinen E (1970) Carcinoma of the gallbladder: a study of 390 cases diagnosed in Finland 1953–1967. Ann Chir Gynaecol 168 [Suppl]: 1–81
Flickinger JC, Epstein AA, Iwatsuki S et al (1991) Radiation therapy for primary carcinoma of the extrahepatic biliary system: an analysis of 63 cases. Cancer 68: 289–294
Todoroki T, Iwasaki Y, Orii K et al (1991) Resection combined with intraoperative radiation therapy (IORT) for stage IV ( TNM) gallbladder carcinoma. World J Surg 15: 357–366
Haskell CM (2001) Bile duct carcinomas. In: Haskell CM (ed) Cancer treatment, 5th edn. Saunders, Philadelphia, pp 790–797
DeGroen PC, Gores GJ, LaRusso NF et al (1999) Biliary tract cancers. N Engl J Med 341: 1368–1378
Klatskin G (1965) Adenocarcinoma of the hepatic duct at its bifurcation with the porta hepatis: an unusual tumor with distinctive clinical and pathological features. Am J Med 38: 241–256
Doll R (1966) Cancer incidence in five continents. Springer, Berlin Heidelberg New York
Sako S, Seitzinger GL, Garside E (1957) Carcinoma of the extrahepatic ducts–a review of the literature and report of 6 cases. Surgery 41: 416–437
Richter JM, Silverstein MD, Shapiro R (1983) Suspected obstructive jaundice: a decision analysis of diagnostic strategies. Ann Intern Med 99: 46–51
Mueller PR, van Sonnenberg E, Sineone JF (1982) Fine-needle transhepatic cholangiography: indications and usefulness. Ann Intern Med 97: 567–572
Blumgart LH (1975) Endoscopy of the upper gastrointestinal tract. In: Longmore WP Jr (ed) Advances in surgery, vol 9. Year Book Medical, Chicago, pp 97–138
Tran LM (2001) Bile duct carcinomas. In: Haskell CM (ed) Cancer treatment, 5th edn. Saunders, Philadelphia, pp 795–797
Perliras RV Jr, Rheingold OB, Huston D et al (1978) Relief of malignant obstructive jaundice by percutaneous insertion of a permanent prosthesis in the biliary tree. Ann Intern Med 89: 589–593
Kozarek RA, Sanowski RA (1982) Nonsurgical management of extrahepatic obstructive jaundice. Ann Intern Med 96: 743–745
Summerfield JA (1988) Biliary obstruction is best managed by endoscopists. Gut 29: 741–745
Rumalla A, Petersen BT (2000) Diagnosis and therapy of biliary tract malignancy. Semin Gastrointest Dis 11: 168–173
Kopelson G, Harisiadis L, Tretter P, Chang CH (1977) The role of radiation therapy in cancer of the extra-hepatic biliary system. Int J Radiat Oncol Biol Phys 2: 883–894
Pilepich MV, Lambert PM (1978) Radiotherapy of carcinomas of the extrahepatic biliary system. Radiology 127: 767–770
Minsky BD, Wessan MF, Armstrong JG et al (1990) Combined modality therapy of extrahepatic biliary system cancer. Int J Radiat Oncol Biol Phys 18: 1157–1163
McMasters KM, Tuttle TM, Leach SD et al (1997) Neoadjuvant chemo-radiation for extrahepatic cholangio-carcinoma. Am J Surg 174: 605–608
Alden ME, Mohiuddin M (1994) The impact of radiation dose in combined external beam and intraluminal Ir-192 brachytherapy for bile duct cancer. Int J Radiat Oncol Biol Phys 28: 945–951
Merimsky O, Nori D, Rogers D et al (1995) Conformal high dose rate percutaneous transhepatic intraluminal cholangio-irradiation for unresectable cholangiocarcinoma. Endocurither Hyperther Oncol 11: 115–120
Morganti AG, Trodella L, Valenti V et al (2000) Combined modality treatment in unresectable extrahepatic biliary carcinoma. Int J Radiat Oncol Biol Phys 46: 913–919
Stillwagon CB, Order S, Guse C et al (1991) Prognostic factors in unresectable hepatocellular cancer: Radiation Therapy Oncology Group Study 8301. Int J Radiat Oncol Biol Phys 20: 65–71
Borgelt BB, Gelber R, Brady LW, Griffin T, Hendrickson FR (1981) The palliation of hepatic metastases: results of the Radiation Therapy Oncology Group Pilot Study. Int J Radiat Oncol Biol Phys 7: 587–591
Leibel SA, Pajak TF, Massullo V et al (1987) A comparison of misonidazole-sensitized radiation therapy to radiation therapy alone for the palliation of hepatic metastases: results of a Radiation Therapy Oncology Group randomized prospective trial. Int J Radiat Oncol Biol Phys 13: 1057–1064
Mohiuddin M, Chen E, Neelofur A (1996) Combined liver radiation and chemotherapy for palliation of hepatic metastases from colorectal cancer. J Clin Oncol 14: 722728
Prasad B, Lee M-S, Hendrickson FR (1977) Irradiation of hepatic metastases. Int J Radiat Oncol Biol Phys 2: 129–132
Phillips R, Karnofsky DA, Hamilton LD, Nickson JJ (1954) Roentgen therapy of hepatic metastases. Am J Roentgenol Rad Ther Phys 71: 826–834
Leibel SA, Guse C, Order SE et al (1990) Accelerated fractionation radiation therapy for liver metastases: selection of an optimal patient population for the evaluation of late hepatic injury in RTOG studies. Int J Radiat Oncol Biol Phys 18: 523–528
Turek-Maischeider M, Kazem I (1975) Palliative irradiation for liver metastases. JAMA 232: 625–628
Ingold JA, Reed GB, Kaplan HS et al (1965) Radiation hepatitis. Am J Roentgenol Ther Nucl Med 93: 200–208
Fajardo FL, Colby TV (1980) Pathogenesis of veno-occlusive liver disease after radiation. Arch Pathol Lab Med 104: 584–588
Reed GB, Cox AJ (1966) The human liver after radiation injury. Am J Pathol 48: 597–611
Fajardo LF (1982) Pathology of radiation injury. Masson, New York, pp 88–96
Fajardo LF, Colby TV (1980) Pathogenesis of veno-occlusive liver disease after radiation. Arch Pathol Lab Med 104: 584–588
Tefft M, Mitus A, Das L, Vawter GF, Filler RM (1970) Irradiation of the liver in children: review of experience in the acute and chronic phases and in the intact normal and partially resected. Am J Roentgenol 108: 365–385
Jirtle RL, Anscher MS, Alati E (1990) Radiation sensitivity of the liver. Adv Radiat Biol 14: 269–311
Lawrence TS, Ten Haken RK, Kessler MC et al (1992) The use of 3-D dose volume analysis to predict radiation hepatitis. Int J Radiat Oncol Biol Phys 23: 781–788
McDonald GB, Sharma P, Matthews DE et al (1984) Venoocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors. Hepatology 4: 116–122
Webber BM, Soderberg CH Jr, Leone LA, Rege VB, Glicksman AS (1978) A combined treatment approach to management of hepatic metastases. Cancer 42: 1087–1095
Friedman M, Cassidy M, Levine M et al (1979) Combined modality therapy of hepatic metastasis. Cancer 44: 906–913
Barone RM, Byfield JE, Goldfarb PB et al (1982) Intra-arterial chemotherapy using implantable infusion pump and liver irradiation for the treatment of hepatic metastases. Cancer 50: 850–862
Rotman M, Kuruvilla AM, Choi K et al (1986) Response of colo-rectal hepatic metastases to concomitant radiotherapy and intravenous 5-fluorouracil. Int J Radiat Oncol Biol Phys 12: 2179–2187
Wiley AL, Wirtanen GW, Stephenson JA et al (1989) Combined hepatic artery 5-fluorouracil and irradiation of liver metastases. Cancer 64: 1783–1789
Robertson JM, Lawrence TS, Walker S et al (1995) The treatment of colorectal liver metastases with conformal radiation therapy and regional chemotherapy. Int J Radiat Oncol Biol Pys 32: 445–450
Robertson JM, McGinn CJ, Walker S et al (1997) A phase I trial of hepatic arterial bromodeoxyuridine and conformal radiation therapy for patients with primary hepatobiliary cancers or colorectal liver metastases. Int J Radiat Oncol Biol Phys 39: 1087–1092
Hughes KS, Simon R, Songhorabodi Set al (1986) Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of patterns of recurrence. Surgery 100: 278–284
Scheele J, Stang R, Attendorf-Hofmann A (1990) Hepatic metastases from colorectal carcinoma: impact of surgical resection on the natural history. Br J Surg 77: 1241–1246
Wilson S, Adson M (1976) Surgical treatment of hepatic metastases from colorectal cancers. Arch Surg 111: 330–334
Jamison R, Donohur J, Nagorney D et al (1997) Hepatic resection for metastatic colorectal cancer: results in cure for some patients. Arch Surg 132: 505–511
Nordlinger B, Guigier M, Vaillant J et al (1996) Surgical resection of colorectal carcinoma metastases to the liver. Cancer 77: 1254–1262
Fong Y, Kemeny N, Paty P et al (1996) Treatment of colorectal cancer: hepatic metastasis. Semin Surg Oncol 12: 219–252
Kemeny N (2001) Management of liver metastases. In: Haskell CM (ed) Cancer management, 5th edn. Saunders, Philadelphia, pp 1590–1607
Kemeny N, Huang Y, Cohen AM et al (1999) Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. N Engl J Med 341: 2039–2048
Kemeny N, Adak S, Lipsitz S et al (1999) Results of the Intergroup (Eastern Cooperative Oncology Group - ECOG and Southwest Oncology Group - SWOG) prospective randomized study of surgery alone versus common hepatic artery infusion of FUDR and continuous systemic infusion of 5-FU after hepatic resection for colorectal liver metastases (abstract 1012). Proc ASCO 18: 264
Niederhuber J, Ensminger W, Gyves J et al (1984) Regional chemotherapy of colorectal cancer metastatic to the liver. Cancer 53: 1336–1343
Kemeny N, Daly J, Reichman B et al (1987) Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases from colorectal carcinoma–a randomized trial. Ann Intern Med 107: 459–467
Hohn D, Stagg R, Friedman M et al (1989) A randomized trial of continuous versus hepatic intra-arterial floxuridine in patients with colorectal cancer metastatic to the liver: the Northern California Oncology Group trial. J Clin Oncol 7: 1646–1654
Chang AE, Schneider PD, Sugarbaker PH (1987) A prospective randomized trial of regional versus systemic continuous 5-fluoroxyuridine chemotherapy in the treatment of colorectal liver metastases. Ann Surg 206: 685–693
Martin JKJ, O’Connell MG, Wieland HS et al (1990) Intraarterial floxuridine vs systemic fluorouracil for hepatic metastases from colorectal cancer: a randomized trial. Arch Surg 125: 1022–1027
Rougier P, Laplanche A, Huguier M et al (1992) Hepatic arterial infusion of floxuridine in patients with liver metastases from colorectal carcinoma: long-term results of a prospective randomized trial. J Clin Oncol 10: 1112–1118
Markowitz J (1952) The hepatic artery. Surg Gynecol Obstet 95: 644–646
Allison D, Modlin I, Jenkins W et al (1977) Treatment of carcinoid liver metastases by hepatic artery embolization. Lancet 2: 1323–1325
Daniels J, Daniels A, Quinn M et al (1988) Phase I trial with cisplatin or mitomycin hepatic embolization (CE) with Angiostat collagen for embolization ( CFE) in patients with colorectal cancer. Proc ASCO 7: 101
Greenlee RT, Murray T, Bolden S, Wingo PA (2000) Cancer statistics, 2000. CA Cancer J Clin 50: 7–33
Myerson RJ, Mohiuddin M, Rich TA (2000) Rectal cancer. In: Gunderson LL, Tepper JE (eds) Clinical radiation oncology. Churchill Livingstone, Edinburgh, pp 728–747
Mendenhall WM, Million RR, Pfaff WW (1983) Patterns of recurrence in adenocarcinoma of the rectum and rectosigmoid treated with surgery alone: implications in treatment planning with adjuvant radiation therapy. Int J Radiat Oncol Biol Phys 9: 997–985
Stockholm Rectal Cancer Study Group (1990) Preoperative short-term radiotherapy in operable rectal carcinoma: a prospective randomized trial. Cancer 60: 49–55
Brierly JD, Cummings BJ, Wong CS et al (1995) Adenocarcinoma of the rectum treated by radical external radiation therapy. Int J Radiat Oncol Biol Phys 31: 255–259
Fletcher WS, Allen CV, Dunphy JE (1964) Pre-operative irradiation for carcinomas of the colon and rectum. Am J Surg 109: 76–83
Stevens KR Jr (1994) The colon and rectum. In: Cox JD (ed) Moss’ radiation oncology: rationale, technique, results, 7th edn. Mosby, St Louis, p 463–486
Tobin RL, Mohiuddin M, Marks G (1991) Preoperative irradiation for cancer of the rectum with extrarectal fixation. Int J Radiat Oncol Biol Phys 21: 1127–1132
Doseretz DE, Gunderson LL, Hedberg S, Hoskins B, Blitzer P, Shipley W, Cohen AM (1983) Preoperative irradiation for unresectable rectal and recto-sigmoid carcinoma. Cancer 52: 814–818
Emami B, Willet C, Pilepich M, Munzenrider J, Miller HM (1982) Effect of preoperative irradiation on resectability of colorectal carcinomas. Int J Radiat Oncol Biol Phys 8: 1295–1299
Fortier GA, Krochak RJ, Jung AK, Constable WC (1986) Dose response to preoperative irradiation in rectal cancer: implications for local control and complications associated with sphincter-sparing surgery and abdominal perineal resection. Int J Radiat Oncol Biol Phys 12: 1559–1563
Mendenhall WM, Bland KI, Pfaff WW, Million RR, Copeland EM (1986) Initially unresectable rectal adenocarcinoma treated with preoperative irradiation and surgery. Ann Surg 205: 41–44
Minsky BD, Cohen AM, Enher WE, Sigurdson E, Harrison L (1991) Radiation therapy for unresectable rectal cancer. Int J Radiat Oncol Biol Phys 21: 1283–1289
Rich TA, Skibber JM, Ajani JA et al (1995) Preoperative infusional chemoradiation therapy for Stage T3 rectal cancer. Int J Radiat Oncol Biol Phys 32: 1025–1029
Law WL, Chu KW, Choi HK (2000) Total pelvic exenteration for locally advanced rectal cancer. J Am Coll Surg 190: 78–83
Goldberg JM, Piver MS, Hempling RE et al (1998) Improvements in pelvic exenteration: factors responsible for reducing morbidity and mortality. Ann Surg Oncol 5: 399–406
Chen H, George BD, Kaufman HS et al (2001) Endoscopic transanal resection provides palliation equivalent to trans-abdominal resection in patients with metastatic rectal cancer. J Gastrointest Surg 5: 282–286
Turler A, Schafer H, Pechlmaier H (1997) Role of transanal endoscopic microsurgery in the palliative treatment of rectal cancer. Scand J Gastroenterol 32: 58–61
Rantala A, Ovaska J (1995) Palliative laser treatment of rectal cancer. Scand J Gastroenterol 30: 177–179
Meijer S, Rahusen FD, van der Plas LG (1999) Palliative cryosurgery for rectal carcinoma. Int J Colorectal Dis 14: 177–180
Coco C, Cogliandolo S, Riccioni ME et al (2000) Use of self-expanding stent in the palliation of rectal cancer recurrence. Surg Endosc 14: 708–711
Williams IG, Horwitz MD (1956) The primary treatment of adenocarcinoma of the rectum by high-voltage roentgen rays (1,000 KV). Am J Roentgenol 76: 919–928
Wang CC, Schulz MD (1962) The role of radiation therapy in the management of carcinoma of the sigmoid, rectosigmoid and rectum. Radiology 79: 1–5
Whiteley HW Jr, Stearns MW Jr, Learning RH, Deddish MR (1969) Radiation therapy in the palliative management of patients with recurrent cancer of the rectum and colon. Surg Clin North Am 49: 381–387
Urdaneta-Lafer N, Kligerman MM, Knowlton AH (1972) Evaluation of palliative irradiation in rectal carcinoma. Radiology 104: 673–677
Vontgtama V, Douglass HO, Moore RH, Holyoke ED, Webster JH (1975) End results of radiation therapy alone and in combination with 5-fluououracil in colorectal cancers. Cancer 36: 2020–2025
Ciatto S, Pacini P (1982) Radiation therapy of recurrences of carcinoma of the rectum and sigmoid after surgery. Acta Radiol Oncol 21 (Fasc 2): 105–109
Overgaard M, Overgaard J, Sell A (1984) Dose-response relationship for radiation therapy of recurrent, residual and primarily inoperable colorectal cancer. Radioather Oncol 1: 217–225
Ampil FL (1986) Palliative irradiation of carcinomatous lumbosacral plexus neuropathy. Int J Radiat Oncol Biol Phys 12: 1681–1686
Carlsson GC, Hafstran L, Jonsson RE, Ask A, Kallum B, Lunderquist A (1986) Unresectable and locally recurrent rectal cancer treated with radiotherapy or bilateral internal iliac artery infusion of 5-fluououracil. Cancer 58: 336–340
Wong R, Thomas G, Cummings B, Froud P, Shelly W, Withers HR, Williams J (1998) In search of a dose-response relationship with radiotherapy in the management of recurrent rectal carcinoma in the pelvis: a systematic review. Int J Radiat Oncol Biol Phys 40: 437–446
Lindareddy V, Ahmad NR, Mohiuddin M (1997) Palliative reirradiation for recurrent rectal cancer. Int J Radiat Oncol Biol Phys 38: 785–790
SEER Cancer Statistics Review 1973–1996
Minsky BD, Hoffman JP, Kelsen DP (2001) Cancer of the anal region. In: DeVita VT Jr, Hellman S, Rosenberg SA (eds) Cancer: principles and practice of oncology, 6th edn. Lippincott, Philadelphia, pp 1319–1342
American Joint Committee on Cancer (1992) Manual for staging of cancer, 4th edn. Lippincott, Philadelphia
Union Internationale Contre le Cancer (1987) TNM Glas- 22. sification of malignant tumors, 4th edn. Springer-Verlag, Berlin
Haskell CM (2001) Anal canal. Natural history, diagnosis, and staging. In: Haskell CM (ed) Cancer treatment, 5th edn. 23. Saunders, Philadelphia, pp 742–745
Harrison EG Jr, Beahrs OH, Hill JR (1966) Anal and perianal malignant neoplasms: pathology and treatment. Dis 24. Colon Rectum 9: 255–267
Boman BM, Moertel CG, O’Connell MJ et al (1984) Carcinoma of the anal canal–a clinical and pathologic study of 188 cases. Cancer 54: 114–125
Stearns MW, Urmacher C, Sternberg SS (1980) Cancer of the anal canal. Curr Probl Cancer 4: 1–44 25.
Cummings BJ (1982) The place of radiation therapy in the treatment of carcinoma of the anal canal. Cancer Treat Rev 26. 9: 125–147
Salmon RJ, Zafrini B, Labit A et al (1986) Prognosis of 27. cloacogenic and squamous cancers of the anal canal. Dis Colon Rectum 29: 336–340
Doggett SW, Green JP, Cantril ST (1988) Efficacy of radia- 28. tion therapy alone for limited squamous cell carcinoma of the anal canal. Int J Radiat Oncol Biol Phys 15: 1069–1072
Singh R, Nime F, Mittleman A (1981) Malignant epithelial tumors of the anal canal. Cancer 48: 411–415 29.
Tanum G (1993) Treatment of relapsing anal carcinoma. Acta Oncol 32: 33–35 30.
Tanum G, Tveit K, Karlsen KO (1991) Diagnosis of anal carcinoma. Doctor’s finger still the best? Oncology 48: 31. 383–386
Myerson RJ, Karnell LH, Menck HR (1997) The National Cancer Data Base report on carcinoma of the anus. Cancer 32. 80: 805–815
Haddock MG, Martenson JA (2000) Anal carcinoma. In: Gunderson LL, Tepper JE (eds) Clinical radiation oncology. 33. Churchill Livingstone, Edinburgh, p 751-
Frost DB, Richards PC, Montague ED et al (1984) Epidermoid cancer of the anorectum. Cancer 53: 1285–1293 34.
Gordon PH (1988) Squamous cell carcinoma of the anal canal. Surg Clin North Am 68: 1391–1399
Rousseau J, Mathieu G, Fenton J et al (1979) Résultats et complications de la radiothérapie des épithéliomas du canal anal Etude de 128 cas traités de 1956 à 1970. Gastroenterol Clin Biol 3: 207–208
Touboul E, Schienger M, Buffat L et al (1994) Epidermoid carcinoma of the anal canal: results of curative intent radiation therapy in a series of 270 patients. Cancer 73: 1569–1579
Nigro ND, Vaitkivicins VK, Buroker T et al (1981) Combined therapy for cancer of the anal canal. Dis Colon Rectum 24: 73–75
UKCCR Anal Cancer Working Party (1996) Epidermoid anal cancer: results from the UKCCR randomized trial of radiotherapy alone versus radiotherapy, 5-fluorouracil and mitomycin. Lancet 348: 1049–1054
Northover J, Meadows H, Ryan C, Gray R (1997) Combined radiotherapy and chemotherapy for anal cancer. Lancet 349: 205–206
Flam M, Madhu J, Pajak FF et al (1996) Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. J Clin Oncol 14: 2527–2539
Cummings BJ, Keane TJ, O’Sullivan B et al (1993) Mitomydin in anal canal carcinoma. Oncology 50 [Suppl 11: 63–69
PCS Consensus Committees, 1996 (1997) Decision trees and management guidelines. Semin Radiat Oncol 7:163-
Tran LM (2001) Anal cancer: radiation therapy. In: Haskell CM (ed) Cancer treatment, 5th edn. Saunders, Philadelphia, pp 746–750
Cummings BJ, Keane TJ, O’Sullivan B et al (1991) Epidermoid anal cancer: treatment by radiotherapy alone or by radiation and 5-FU with or without mitomycin-C. Int J Radiat Oncol Biol Phys 21: 1115–1125
Nigro ND (1987) Multi-disciplinary management of cancer of the anus. World J Surg 11: 446–451
Golden GT, Horsley JS (1976) Surgical management of epidermoid carcinoma of the anus. Am J Surg 131: 275–280
Cantril ST, Green JP, Schall GL, Schaupp WC (1983) Primary radiation therapy in the treatment of anal carcinoma. Int J Radiat Oncol Biol Phys 9: 1271–1278
Papillon J (1982) Rectal and anal cancers: conservative treatment by irradiation. An alternative to radical surgery. Springer, Berlin Heidelberg New York
Cummings BJ (1998) Anal canal. In: Perez CA, Brady LW (eds) Principles and practice of radiation oncology, 3rd edn. Lippincott-Raven, Philadelphia, pp 1511–1524
Holland JM, Swift PS (1994) Tolerance of patients with human immunodeficiency virus and anal carcinoma to treatment with combined chemotherapy and radiation therapy. Radiology 193: 251–254
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Parker, R.G., Janjan, N.A., Selch, M.T. (2003). Gastrointestinal Cancers. In: Radiation Oncology for Cure and Palliation. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05225-9_7
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