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Ultrathin Electrochemical Chemo- and Biosensors pp 159–180Cite as

Living Cells on Chip: Bioanalytical Applications

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Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 2))

Abstract

Cells are able to respond in an extremely sensitive way to changes in their environment. Electronic microstructures on sensor chips can be applied to analyse such responses by recording properties of cell metabolism and cell morphology. These parameters are linked intimately to the cellular signalling network and can thus be used as sensitive indicators for any perturbation of cellular physiology like toxic insults or receptor activation events. Sensor chips might be able to fill a gap by providing functional and dynamic assays related to cell metabolism and cell morphology. Arraying of sensor chips is a prerequisite in order to make such novel types of cell-based assays work efficiently. It depends on technological efforts in chip packaging and electrical connections, electronic sensor control and specific modes of automated liquid handling. A presentation of solutions developed in the authors’ laboratory is given but other approaches in the field of sensor-based cellular analysis will also be included.

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Abbreviations

MOSFET:

Metal oxide semiconducting field-effect transistor

ISFET:

Ion-sensitive field-effect transistor

IDES:

Interdigitated electrode structure

LAPS:

Light-activated potentiometric sensor

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Authors
  1. Martin Brischwein
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  2. Helmut Grothe
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  3. Angela M. Otto
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  4. Christoph Stepper
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  5. Thomas Weyh
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  6. Bernhard Wolf
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Editor information

Editors and Affiliations

  1. Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany

    Vladimir M. Mirsky

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© 2004 Springer-Verlag Berlin Heidelberg

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Brischwein, M., Grothe, H., Otto, A.M., Stepper, C., Weyh, T., Wolf, B. (2004). Living Cells on Chip: Bioanalytical Applications. In: Mirsky, V.M. (eds) Ultrathin Electrochemical Chemo- and Biosensors. Springer Series on Chemical Sensors and Biosensors, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05204-4_7

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  • DOI: https://doi.org/10.1007/978-3-662-05204-4_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-05961-2

  • Online ISBN: 978-3-662-05204-4

  • eBook Packages: Springer Book Archive

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