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Electrostriction of Supported Lipid Membranes and Their Application in Biosensing

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Ultrathin Electrochemical Chemo- and Biosensors

Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 2))

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Abstract

This review reports the significance of bilayer lipid membranes on a solid support (sBLM) for the construction of biosensors. The methods of formation of lipid membranes on different solid supports, including different metals (silver, gold, stainless steel, mercury), agar, and conducting polymers, are presented. Several examples of the application of electrostriction and dielectric relaxation methods for the study of the mechanical properties and dynamics of solid-supported bilayers are shown. We demonstrate that these methods are useful for studying the physical properties of chemically modified supported membranes, the interaction of surfactants and nucleic acids with lipid membranes, the binding of enzymes and antibodies to sBLM, and hybridization of nucleic acids on the membrane surface. A comparison of the mechanical properties of sBLM of various compositions and method of formation is presented.

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Abbreviations

Ab:

Antibody

Ag:

Antigen

ACH:

Acetylcholinesterase

A-GOX:

Avidin-modified glucose oxidase

A-IgG:

Avidin-modified immunoglobulin G

B-BLM:

Bilayer lipid membrane composed of biotinylated phospholipids

BLM:

Bilayer lipid membranes

(dT)15:

5’-Deoxypentadecylthymidylate

(dA)15:

5’-Deoxypentadecyladenylate

C:

Capacitance

Cs :

Specific capacitance

CH(dT)15:

5’-Cholesterolphosphoryl deoxypentadecyldeoxythymidic acid

C16(dT)15:

5’-Palmitylphosphoryl deoxypentadecyldeoxythymidic acid

cmc:

Critical micellar concentration

COB:

Crude ox brain fraction

CTAB:

Cetyltrimethylammonium bromide

d:

Thickness

DDA:

Dodecylamine

DNA:

Deoxyribonucleic acid

DPPC:

Dipalmitoylphosphatidylcholine

DTAB:

Dodecyltrimethylammonium bromide

e0 :

Elementary charge

E⊥ :

Elasticity modulus

f:

Frequency

fr :

Reduction factor

gs :

Specific conductivity

GMO:

Glycerol monooleate

GOX:

Glucose oxidase

HDA:

Hedadecylamine

HDM:

Hexadecylmercaptan

I:

Current

K:

Volume compressibility modulus

Kb :

Binding constant

m:

Hill coefficient

N:

Number of binding sites

P:

Pressure

Qd :

Total charge transferred due to dipole reorientation

Qe :

Total charge transferred due to changes of potential

R:

Resistance

S:

Area

SBPC:

Soybean phosphatidylcholine

sBLM:

Supported bilayer lipid membranes

tBLM:

Tethered bilayer lipid membranes

TBL:

Total fraction of phospholipids from bovine brain

V:

Voltage

12T:

Dodecanethiol

α:

Electrostriction coefficient

∆Φm :

Intrinsic membrane potential

ε:

Relative dielectric permittivity

ε0 :

Permittivity of free space

η:

Coefficient of dynamic viscosity

Ï„:

Relaxation time

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Authors
  1. Tibor Hianik
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Editors and Affiliations

  1. Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany

    Vladimir M. Mirsky

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Hianik, T. (2004). Electrostriction of Supported Lipid Membranes and Their Application in Biosensing. In: Mirsky, V.M. (eds) Ultrathin Electrochemical Chemo- and Biosensors. Springer Series on Chemical Sensors and Biosensors, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05204-4_12

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  • DOI: https://doi.org/10.1007/978-3-662-05204-4_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-05961-2

  • Online ISBN: 978-3-662-05204-4

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