Photodynamic Therapy: A Novel Approach to the Treatment of AMD

  • I. Barbazetto
  • Ursula Schmidt-Erfurth


Age-related macular degeneration (AMD) is a degenerative eye disease that can cause severe and irreversible loss of central vision. While most patients with AMD experience only a slow, moderate decrease of visual acuity as a result of atrophic changes of the retina, 10% of patients suffer from a severe and rapidly developing visual loss. According to literature and clinical experience, up to 90% of this significantly affected group present with the neovascular form of AMD (Bressler et aI.1982; Guyer et al.1986; Bressler et al.1988). This form is characterized by the development of abnormal blood vessels under the retina, which leak fluid, lipids and blood.Over time the leakage leads to fibrosis of the central retina with loss of photoreceptors and concomitant vision decline (Bressler et al.1982). In North America and Europe this is the leading cause of legal blindness in people over 65 years of age (Leibowitz et al.1980).


Visual Acuity Retinal Pigment Epithelium Photodynamic Therapy Choroidal Neovascularization Pathologic Myopia 
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  • I. Barbazetto
  • Ursula Schmidt-Erfurth

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