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Adenosine Stress Echocardiography

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Abstract

Adenosine stress testing is a procedure in which patients are exposed to intravenous infusion of adenosine with simultaneous monitoring of symptoms, hemodynamic parameters, electrocardiogram and echocardiography image. Instead of echocardiography, myocardial scintigraphy or positron emission tomography can be utilized.

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References

  1. Fredholm BB, Abbracchio MP, Burnstock G, et al (1994) Nomenclature and classification of purinoceptors. Pharmacol Rev 46:143–156

    PubMed  CAS  Google Scholar 

  2. Belardinelli L, Linden J, Berne RM (1989) The cardiac effects of adenosine. Prog Cardiovasc Dis 32:73–97

    Article  PubMed  CAS  Google Scholar 

  3. Iskandrian AS, Verani MS, Heo J (1994) Pharmacologic stress testing: mechanism of action, hemodynamic responses, and results in detection of coronary artery disease. J Nucl Cardiol 1:94–111

    Article  PubMed  CAS  Google Scholar 

  4. Biaggioni I, Olafsson B, Robertson RM, et al (1987) Cardiovascular and respiratory effects of adenosine in conscious man. Evidence for chemoreceptor activation. Circ Res 61:779–786

    Article  PubMed  CAS  Google Scholar 

  5. Ely SW, Berne RM (1992) Protective effects of adenosine in myocardial ischemia. Circulation, 8: 893–904

    Article  Google Scholar 

  6. Belardinelli L, Pelleg A (1995). Adenosine and adenine nucleotides: from molecular biology to integrative physiology. Kluwer Academic, Boston

    Book  Google Scholar 

  7. Wilson RF, Wyche K, Christensen BV, et al (1990) Effects of adenosine on human coronary arterial circulation. Circulation 82:1595–1606

    Article  PubMed  CAS  Google Scholar 

  8. Kern MJ, Deligonul U, Tatineni S, et al (1991) Intravenous adenosine: continuous infusion and low-dose bolus administration for determination of coronary vasodilator reserve in patients with and without coronary artery disease. J Am Coll 18:718–729

    Article  CAS  Google Scholar 

  9. Rossen JD, Quillen JE, Lopez AG, et al (1991) Comparison of coronary vasodilation with intravenous dipyridamole and adenosine. J Am Coll Cardiol 18:485–491

    Article  PubMed  CAS  Google Scholar 

  10. Picano E, Abbracchio MP (2000) Adenosine, the imperfect endogenous anti-ischemic car-dio-neuroprotector. Brain Res Bull 52:75–82

    Article  PubMed  CAS  Google Scholar 

  11. Conradson T-BG, Dixon CMS, Clarke B, et al (1987) Cardiovascular effects of infused adenosine in man: potentiation by dipyridamole. Acta Physiol Scand 129:387–391

    Article  PubMed  CAS  Google Scholar 

  12. Ogilby JD, Iskandrian AS, Untereker WJ, et al (1992) Effect of intravenous adenosine infusion on myocardial perfusion and function. Hemodynamic/angiographic and scintigraphic study. Circulation 86:887–895

    Article  PubMed  CAS  Google Scholar 

  13. Beleslin BD, Ostojic M, Djordjevic-Dikic A, et al (1997) Coronary vasodilation without myocardial erection. Simultaneous haemodynamic, echocardiographic and arteriographic findings during adenosine and dipyridamole infusion. Eur Heart J 18:1166–1174

    Article  PubMed  CAS  Google Scholar 

  14. Verani MS, Mahmarian JJ, Hixson JB, et al (1990) Diagnosis of coronary artery disease by controlled coronary vasodilation with adenosine and thallium-201 scintigraphy in patients unable to exercise. Circulation 82:80–87

    Article  PubMed  CAS  Google Scholar 

  15. Nguyen T, Heo J, Ogilby JD, et al (1990) Single photon emission computed tomography with thallium-201 during adenosine-induced coronary hyperemia: correlation with coronary arteriography, exercise thallium imaging and two-dimensional echocardiography. J Am Coll Cardiol 16:1375–1383

    Article  PubMed  CAS  Google Scholar 

  16. Zoghbi WA, Cheirif J, Kleiman NS, et al (1991) Diagnosis of ischemic heart disease with adenosine echocardiography. J Am Coll Cardiol 18:1271–1279

    Article  PubMed  CAS  Google Scholar 

  17. Edlund A, Albertsson P, Caidahl K, et al (1991) Adenosine infusion to patients with ischaemic heart disease may provoke left ventricular dysfunction detected by echocardiography. Clin Physiol 11:477–488

    Article  PubMed  CAS  Google Scholar 

  18. Martin TW, Seaworth JF, Johns JP, et al (1992) Comparison of adenosine, dipyridamole, and dobutamine in stress echocardiography. Ann Intern Med 116:190–196

    PubMed  CAS  Google Scholar 

  19. Marwick T, Willemart B, D’Hondt AM, et al (1993) Selection of the optimal nonexercise stress for the evaluation of ischemic regional myocardial dysfunction and malperfusion. Comparison of dobutamine and adenosine using echocardiography and 99mTc-MIBI single photon emission computed tomography. Circulation 87:345–354

    Article  PubMed  CAS  Google Scholar 

  20. Case RA, Buckmire R, McLaughlin DP, et al (1994) Physiological assessment of coronary artery disease and myocardial viability in ischemic syndromes using adenosine echocardiography. Echocardiography 11:133–143

    Article  PubMed  CAS  Google Scholar 

  21. Takeishi Y, Chiba J, Abe S, et al (1994) Adenosine-induced heterogeneous perfusion accompanies myocardial ischemia in the presence of advanced coronary artery disease. Am Heart J 127:1262–1268

    Article  PubMed  CAS  Google Scholar 

  22. Tawa CB, Baker WB, Kleiman NS, et al (1996) Comparison of adenosine echocardiography, with and without isometric handgrip, to exercise echocardiography in the detection of ischemia in patients with coronary artery disease. J Am Soc Echocardiogr 9:33–43

    Article  PubMed  CAS  Google Scholar 

  23. Djordjevic-Dikic AD, Ostojic MC, Beleslin BD, et al (1996) High-dose adenosine stress echocardiography for noninvasive detection of coronary artery disease. J Am Coll Cardiol 28:1689–1695

    Article  PubMed  CAS  Google Scholar 

  24. Miyazono Y, Kisanuki A, Toyonaga K, et al (1998) Usefulness of adenosine triphosphate-atropine stress echocardiography for detecting coronary artery stenosis. Am J Cardiol 82:290–294

    Article  PubMed  CAS  Google Scholar 

  25. Cerqueira MD, Verani MS, Schwaiger M, et al (1994) Safety profile of adenosine stress perfusion imaging: results from the Adenoscan Multicenter Trial Registry. J Am Coll Cardiol 23:384–389

    Article  PubMed  CAS  Google Scholar 

  26. Lette J, Tatum JL, Fraser S, et al (1995) Safety of dipyridamole testing in 73,806 patients: the Multicenter Dipyridamole Safety Study. J Nucl Cardiol 2:3–17

    Article  PubMed  CAS  Google Scholar 

  27. Picano E, Marini C, Pirelli S, et al (1992) Safety of intravenous high-dose dipyridamole echocardiography. The Echo-Persantine International Cooperative Study Group. Am J Cardiol 70:252–258

    Article  PubMed  CAS  Google Scholar 

  28. Picano E, Mathias W Jr, Pingitore A, et al on behalf of the EDIC study group (1994) Safety and tolerability of dobutamine-atropine stress echocardiography: a prospective, large-scale, multicenter trial. Lancet 344:1190–1192

    Article  PubMed  CAS  Google Scholar 

  29. Polad JE, Wilson LM (2002) Myocardial infarction during adenosine stress test. Heart 87:E2

    Article  Google Scholar 

  30. Lerman BB, Wesley RC, Belardinelli L (1989) Electrophysiologic effects of dipyridamole on atrioventricular nodal conduction and supraventricular tachycardia. Role of endogenous adenosine. Circulation 80:1536–1543

    Article  PubMed  CAS  Google Scholar 

  31. Conradson TB, Dixon CM, Clarke B, et al (1987) Cardiovascular effects of infused adenosine in man: potentiation by dipyridamole. Acta Physiol Scand 129:387–391

    Article  PubMed  CAS  Google Scholar 

  32. Patsilinakos SP, Kranidis AI, Antonelis IP, et al (1999) Detection of coronary artery disease in patients with severe aortic stenosis with noninvasive methods. Angiology 50:309–317

    Article  PubMed  CAS  Google Scholar 

  33. Anthopoulos LP, Bonou MS, Kardaras FG, et al (1996) Stress echocardiography in elderly patients with coronary artery disease: applicability, safety and prognostic value of dobuta-mine and adenosine echocardiography in elderly patients. J Am Coll Cardiol 28:52–59

    Article  PubMed  CAS  Google Scholar 

  34. Lafitte S, Matsugata H, Peters B, et al (2001) Comparative value of dobutamine and adenosine stress in the detection of coronary stenosis with myocardial contrast echocardiography. Circulation 103:2724–2730

    Article  PubMed  CAS  Google Scholar 

  35. Villanueva FS, Gertz EW, Csikari M, et al (2001) Detection of coronary artery stenosis with power Doppler imaging. Circulation 103:2624–2630

    Article  PubMed  CAS  Google Scholar 

  36. Heinle SK, Noblin J, Goree-Best P, et al (2000) Assessment of myocardial perfusion by harmonic power Doppler imaging at rest and during adenosine stress: comparison with (99m)Tc-sestamibi SPECT imaging. Circulation 102:55–60

    Article  PubMed  CAS  Google Scholar 

  37. Bartel T, Yang Y, Muller S, et al (2002) Noninvasive assessment of microvascular function in arterial hypertension by transthoracic Doppler harmonic echocardiography. J Am Coll Cardiol 39:2012–2018

    Article  PubMed  Google Scholar 

  38. Hirata K, Shimada K, Watanabe H, et al (2001) Modulation of coronary flow velocity reserve by gender, menstrual cycle and hormone replacement therapy. J Am Coll Cardiol 38:1879–1884

    Article  PubMed  CAS  Google Scholar 

  39. Pizzuto F, Voci P, Mariano E, et al (2001) Assessment of flow velocity reserve by transthoracic Doppler echocardiography and venous adenosine infusion before and after left anterior descending coronary artery stenting. J Am Coll Cardiol 38:155–162

    Article  PubMed  CAS  Google Scholar 

  40. Marwick TH (1997) Adenosine echocardiography in the diagnosis of coronary artery disease. Eur Heart J [Suppl D]:D31–D36

    Google Scholar 

  41. Rodriguez Garcia MA, Iglesias-Garriz I, Corral Fernandez F, et al (2001) Evaluation of the safety of stress echocardiography in Spain and Portugal. Rev Esp Cardiol 54:941–948

    PubMed  CAS  Google Scholar 

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© 2003 Springer-Verlag Berlin Heidelberg

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Ostojic, M., Djordjevic-Dikic, A., Picano, E. (2003). Adenosine Stress Echocardiography. In: Stress Echocardiography. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05096-5_13

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  • DOI: https://doi.org/10.1007/978-3-662-05096-5_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-05098-9

  • Online ISBN: 978-3-662-05096-5

  • eBook Packages: Springer Book Archive

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