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MALDI-TOF Mass Spectrometry of Synthetic Polymers pp 209–287Cite as

Coupling of Liquid Chromatography and MALDI-TOF Mass Spectrometry

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Abstract

From the very early stages of development of modern mass spectrometry, the value of its combination with chromatography was quickly recognized. The coupling of GC with MS was a natural evolution since they are both vapor phase techniques, and very quickly GC-MS has been accepted as a standard component of the organic analytical laboratory. It has taken considerably longer to achieve a satisfactory and all-purpose mode of HPLC-MS coupling. The difficulties with HPLC-MS were associated with the fact that vaporization of typically 1 ml/min from the HPLC translates into a vapor flow rate of approximately 500–1000 ml/min. Other difficulties related to the eluent composition as result of the frequent use of non-volatile modifiers, and the ionization of nonvolatile and thermally labile analytes. However, during the past few years commercial interfaces have been developed which have led to a broad applicability of HPLC-MS [1–3].

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Authors and Affiliations

  1. Deutsches Kunststoff-Institut, Abt. Analytik, Schloßgartenstraße 6, 64289, Darmstadt, Germany

    Priv.-Doz. Dr. Harald Pasch

  2. BASF AG, Kunststofflabor GKP/O-G201, 67056, Ludwigshafen, Germany

    Dr. Wolfgang Schrepp

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  1. Priv.-Doz. Dr. Harald Pasch
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  2. Dr. Wolfgang Schrepp
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Pasch, H., Schrepp, W. (2003). Coupling of Liquid Chromatography and MALDI-TOF Mass Spectrometry. In: MALDI-TOF Mass Spectrometry of Synthetic Polymers. Springer Laboratory. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05046-0_7

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  • DOI: https://doi.org/10.1007/978-3-662-05046-0_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-07923-8

  • Online ISBN: 978-3-662-05046-0

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