Activation of Primordial Follicles

  • J. E. Fortune
Conference paper
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 41)

Abstract

The development of ovarian follicles is a protracted process. Even in rodents, it is estimated to take about 8 weeks for development from the primordial to the preovulatory stage (Hirshfield 1991), and estimates for larger mammals like humans and cattle are around 6 months (Gougeon 1996). Although follicular growth and differentiation are gradual and continuous processes, there are critical transitional points in follicular development. They include initiation of follicular growth, selection of a dominant follicle capable of ovulating, and the transformation of a preovulatory follicle into a periovulatory follicle in response to the luteinizing hormone/follicle-stimulating hormone (LH/FSH) surge. This review will focus on the first of these critical transitions, the initiation of follicular growth. Understanding the signals that regulate the activation of primordial follicles is of practical importance since it could stimulate new ideas for contraceptive approaches or lead to methods to enhance fertility in women, domestic animals, and endangered species.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Blakesley VA, Scimgeour A, Esposito D, Le Roith D (1996) Signaling via the insulin-like growth factor-I receptor: does it differ from insulin receptor signaling? Cytokine Growth Factor Rev 7: 153–159PubMedCrossRefGoogle Scholar
  2. Braw-Tal R, Yossefi S (1997) Studies in vivo and in vitro on the initiation of follicle growth in the bovine ovary. J Reprod Fertil 109: 165–171PubMedCrossRefGoogle Scholar
  3. Cushman RA, Gigli I, Wahl CM, Fortune JE (2001) Activation of mouse primordial follicles is inhibited in chorioallantoic membrane grafts. Biol Re-prod 64 [Supp11]: 110Google Scholar
  4. Cushman RA, Wahl CM, Fortune JE (2002) Bovine ovarian cortical pieces grafted to chick embryonic membranes: a model for studies on the activation of primordial follicles. Hum Reprod 17: 48–52PubMedCrossRefGoogle Scholar
  5. Derrar N, Price CA, Sirard M-A (2000) Effect of growth factors and co-culture with ovarian medulla on the activation of primordial follicles in explants of bovine ovarian cortex. Theriogenology 54: 587–598PubMedCrossRefGoogle Scholar
  6. DiClemente N, Ghaffari S, Pepinsky RB, Pieau C, Josso N, Cate RL, Vigier B (1992) A quantitative and interspecific test for biological activity of anti—Müllerian hormone: the fetal ovary aromatase assay. Development 114: 721–727Google Scholar
  7. Dissen GA, Romero C, Hirshfield AN, Ojeda SR (2001) Nerve growth factor is required for early follicular development in the mammalian ovary. Endocrinology 142: 2078–2086PubMedCrossRefGoogle Scholar
  8. Durlinger ALL, Kramer P, Karels B, de Jong FH, Uilenbroek JTJ, Grootegoed JA, Themmen APN (1999) Control of primordial follicle recruitment by anti-Müllerian hormone in the mouse ovary. Endocrinology 140: 5789–5796PubMedCrossRefGoogle Scholar
  9. Durlinger ALL, Gruijters MJG, Kramer P, Karels B, Ingraham HA, Nachtigal MW, Uilenbroek JTJ, Grootegoed JA, Themmen APN (2002) AntiMüllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary. Endocrinology 143: 1076–1084PubMedCrossRefGoogle Scholar
  10. Eppig JJ, O’Brien MJ (1996) Development in vitro of mouse oocytes from primordial follicles. Biol Reprod 54: 197–207PubMedCrossRefGoogle Scholar
  11. Fortune J, Kito S, Wandji S—A, Srsen V (1998) Activation of bovine and baboon primordial follicles in vitro. Theriogenology 49: 441–449PubMedCrossRefGoogle Scholar
  12. Fortune JE, Kito S, Byrd DD (1999) Activation of primordial follicles in vitro. J Reprod Fertil Suppl 54:439 418 Google Scholar
  13. Fortune JE, Cushman RA, Wahl CM, Kito S (2000) The primordial to primary follicle transition. Mol Cell Endocrinol 163: 53–60PubMedCrossRefGoogle Scholar
  14. Gougeon A (1996) Regulation of ovarian follicular development n primates: Facts and hypotheses. Endocrine Rev 17: 121–155Google Scholar
  15. Henricson B, Rajakoski E (1959) Studies of oocytogenesis in cattle. Cornell Vet 49: 494–503PubMedGoogle Scholar
  16. Herrmann G, Spanel-Borowski K (1998) A sparsely vascularized zone in the cortex of the bovine ovary. Anat Histol Embryol 27: 143–146PubMedCrossRefGoogle Scholar
  17. Hirshfield AN (1991) Development of follicles in the mammalian ovary. Int Rev Cytol 124: 43–101PubMedCrossRefGoogle Scholar
  18. Mayerhofer A, Dissen GA, Costa ME, Ojeda SR (1997) A role for neurotransmitters in early follicular development: induction of functional follicle-stimulating hormone receptors in newly formed follicles of the rat ovary. Endocrinology 138: 3320–3329PubMedCrossRefGoogle Scholar
  19. McNatty KP, Fidler AE, Juengel JL, Quirke LD, Smith PR, Heath DA, Lundy T, O’Connell AO, Tisdall DJ (2000) Growth and paracrine factors regulating follicular formation and cellular function. Mol Cell Endocrinol 163: 11–20PubMedCrossRefGoogle Scholar
  20. Nilsson E, Skinner MK (2001) Cellular interactions that control primordial follicle development and folliculogenesis. J Soc Gynecol Invest 8:S17–S20 Picton HM (2001) Activation of follicle development: the primordial follicle. Theriogenology 55: 1193–1210Google Scholar
  21. Rawles M (1952) Transplantation of normal embryonic tissues in the chick embryo in biological research. Annals NY Acad Sci 55: 302CrossRefGoogle Scholar
  22. Rudnick D (1944) Early history and mechanics of the chick blastoderm. Quart Rev Biol 197: 187Google Scholar
  23. Russe I (1983) Oogenesis in cattle and sheep. Bibl Anat 24: 77–92PubMedGoogle Scholar
  24. van Wagenen G, Simpson ME (1965) Embryology of the ovary and testis. Homo sapiens and Macaca mulatta. Yale University Press, New HavenGoogle Scholar
  25. van Wezel IL, Rodgers RJ (1996) Morphological characterization of bovine primordial follicles and their environment in vivo. Biol Reprod 55: 1003–1011PubMedCrossRefGoogle Scholar
  26. Wandji S-A, Srsen V, Voss AK, Eppig JJ, Fortune JE (1996) Initiation in vitro of growth of bovine primordial follicles. Biol Reprod 55: 942–948PubMedCrossRefGoogle Scholar
  27. Wandji S-A, Srsen V, Nathanielsz PW, Eppig JJ, Fortune JE (1997) Initiation of growth of baboon primordial follicles in vitro. Hum Reprod 12: 1993–2001PubMedCrossRefGoogle Scholar
  28. Yang MY, Fortune JE (2002) Insulin and IGF-I exert opposite effects on the activation of bovine primordial follicles in vitro. Biol Reprod 66[Suppl 11: 111Google Scholar
  29. Yu N, Roy SK (1999) Development of primordial and prenatal follicles from undifferentiated somatic cells and oocytes in the hamster prenatal ovary in vitro: effect of insulin. Biol Reprod 61: 1558–1567PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • J. E. Fortune

There are no affiliations available

Personalised recommendations