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Can Stimulation Protocols Improve Oocyte Quality?

  • J. Smitz
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 41)

Abstract

Ovarian follicle development in humans is a lengthy process that takes several months. Initial follicle recruitment from the resting pool is regulated by intraovarian factors and independent of circulating gonadotropin concentrations. Once follicles have initiated growth, they progress through a slow preantral growth phase (approximately 4 months) during which the formation of zona pellucida, granulosa cell layers, theca cell layers, and vascularization of the theca externa are accomplished (for review, see Richards 2001). The preantral growth stages are mainly under paracrine/autocrine control but the somatic cells already express the receptors for gonadotropins (Sokka et al. 1996; Oktay et al. 1997). Although the growth of preantral follicles are considered to be gonadotropin-independent, there are arguments that gonadotropin fluctuations may effect these early growing follicles (Parrot and Skinner 1998a,b). Along the lengthy track of follicle growth, granulosa cells are stimulated by a variety of factors such as epidermal growth factor (EGF), insulin-like growth factor-1 (IGF-1), basic fibroblast growth factor (bFGF), transforming growth factor α (TGF-α) and keratinocyte growth factor (KGF).

Keywords

Granulosa Cell GnRH Agonist Antral Follicle Keratinocyte Growth Factor Human Oocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2002

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  • J. Smitz

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