Skip to main content
SpringerLink
Log in

Fc Receptor Homologs (FcRH1-5) Extend the Fc Receptor Family

  • Chapter
Book cover The Interface Between Innate and Acquired Immunity

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 266))

Abstract

Receptors for the Fc portion of immunoglobulins (FcR) are expressed broadly among cells of the immune system (Ravetch and Kinet 1991; Daeron 1997). The differential expression of these Ig isotope-specific receptors enable them to modulate cellular and humoral immunity by linking their antibody ligands with effector cells. These cellular receptors have the ability to sense humoral concentrations of antibody, initiate cellular responses in host defense, and participate in autoimmune disorders (Ravetch and Bolland 2001). The diverse regulatory roles of FcR depend upon their Ig isotype specificity, cellular distribution, and cytoplasmic signaling elements. The different FcR molecules share similarities in their ligand-binding subunits and overall extracellular structures, but they differ in their transmembrane and cytoplasmic regions in two major ways. These receptors either have self-contained inhibitory or activating signaling motifs or instead they use charged residues in their transmembrane region to pair with signal-transducing adaptor chains possessing activating signaling motifs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, Powell JI, Yang L, Marti GE, Moore T, Hudson J Jr, Lu L, Lewis DB, Tibshirani R, Sherlock G, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Warnke R, Staudt LM (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403: 503–511

    Article  PubMed  CAS  Google Scholar 

  • Alley TL, Cooper MD, Chen M, Kubagawa H (1998) Genomic structure of PIR-B, the inhibitory member of the paired immunoglobulin-like receptor genes in mice. Tissue Antigens 51: 224–3144

    Article  PubMed  CAS  Google Scholar 

  • Altschul SF, Gish W, Miller W, Meyers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215: 403–410

    PubMed  CAS  Google Scholar 

  • Amigorena S, Bonnerot C, Choquet D, Fridman WH, Teillaud JL (1989) FcyRII expression in resting and activated B lymphocytes. Eur J Immunol 19: 1379–1385

    Article  PubMed  CAS  Google Scholar 

  • Barten R, Torkar M, Haude A, Trowsdale J, Wilson MJ (2001) Divergent and convergent of NK-cell receptors. Trends Immunol 22: 52–57

    Article  PubMed  CAS  Google Scholar 

  • Bolland S, Ravetch JV (2000) Spontaneous autoimmune disease in FcyRIIB-deficient mice results from strain-specific epistasis. Immunity 13: 277–285

    Article  PubMed  CAS  Google Scholar 

  • Borges L, Hsu M-L, Fanger N, Kubin M, Cosman D (1997) A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules J Immunol 159: 5192–5196

    CAS  Google Scholar 

  • Callanan MB, Le Baccon P, Mossuz P, Duley S, Bastard C, Hamoudi R, Dyer MJ, Klobeck G, Rimokh R, Sotto JJ, Leroux D (2000) The IgG Fc receptor, FcyRIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma. Proc Natl Acad Sci USA 97: 309–314

    Google Scholar 

  • Chapman TL, Heikeman AP, Bjorkman RI (1999) The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18. Immunity 11: 603–613

    Article  PubMed  CAS  Google Scholar 

  • Chapman TL, Heikema AP, West AP Jr, Bjorkman PJ (2000) Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2). Immunity 13: 727–736

    Article  PubMed  CAS  Google Scholar 

  • Cigudosa JC, Parsa NZ, Louie DC, Filippa DA, Jhanwar SC, Johansson B, Mitelman F, Chaganti RS (1999) Cytogenetic analysis of 363 consecutively ascertained diffuse large B-cell lymphomas. Genes Chromosom Cancer 25: 123–133

    Article  PubMed  CAS  Google Scholar 

  • Clynes R, Dumitru C, Ravetch JV (1998) Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science 279: 1052–1054

    Article  PubMed  CAS  Google Scholar 

  • Clynes RA, Towers TL, Presta LG, Ravetch JV (2000) Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nature Med 6: 443–446

    Article  PubMed  CAS  Google Scholar 

  • Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Cella M, Lopez-Botet M (1997) A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J Exp Med 186: 1809–1818

    Article  PubMed  CAS  Google Scholar 

  • Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML (1997) A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity 7: 273–282

    Article  PubMed  CAS  Google Scholar 

  • Daeron M (1997) Fc receptor biology. Annu Rev Immunol 15: 203–234

    Article  PubMed  CAS  Google Scholar 

  • Daeron M, Vivier E (1999) Biology of immunoreceptor tyrosine-based inhibition motif-bearing molecules. Current Topics in Microbiol Immunol 244: 1–12

    Article  CAS  Google Scholar 

  • Daeron M, Latour S, Malbec O, Espinosa E, Pina P, Pasmans S, Fridman WH (1995) The same tyrosine-based inhibition motif, in the intracytoplasmic domain of FcyRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation. Immunity 3: 635–646

    Google Scholar 

  • D’Ambrosio D, Hippen KL, Minskoff SA, Mellman I, Pani G, Siminovitch KA, Cambier JC (1995) Recruitment and activation of PTP1 C in negative regulation of antigen receptor signaling by Fc gamma RI1B1. Science 268 (5208): 293–297

    Article  PubMed  Google Scholar 

  • Davis RS, Wang YH, Kubagawa H, Cooper MD (2001) Identification of a family of Fc receptor homologs with preferential B cell expression. Proc Natl Acad Sci USA 98: 9772–9777

    Article  PubMed  CAS  Google Scholar 

  • Dennis G Jr, Kubagawa H, Cooper MD (2000) Paired Ig-like receptor homologs in birds and mammals share a common ancestor with mammalian Fc receptor. Proc Natl Acad Sci USA 97: 13245–13250

    Article  PubMed  CAS  Google Scholar 

  • Dyall R, Vasovic LV, Clynes RA, Nikolic-Zugic J (1999) Cellular requirements for the monoclonal antibody-mediated eradication of an established solid tumor. Eur J Immunol 29: 30–37

    Article  PubMed  CAS  Google Scholar 

  • Dyomin VG, Palanisamy N, Lloyd KO, Dyomina K, Jhanwar SC, Houldsworth J, Chaganti RS (2000) MUCI is activated in a B-cell lymphoma by the t(1;14)(g21;g32) translocation and is rearranged and amplified in B-cell lymphoma subsets. Blood 95: 2666–2671

    PubMed  CAS  Google Scholar 

  • Ernst LK, Duchemin AM, Anderson CL (1993) Association of the high-affinity receptor for IgG ( Fc gamma RI) with the gamma subunit of the IgE receptor. Proc Natl Acad Sci USA 90: 6023–6027

    Google Scholar 

  • Fan QR, Mosyak L, Winter CC, Wagtmann N, Long EO, Wiley DC (1997) Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors. Nature 389: 96–100

    Article  PubMed  CAS  Google Scholar 

  • Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L (1998) The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. Eur J Immunol 28: 3423–3434

    Article  PubMed  CAS  Google Scholar 

  • Garman SC, Kinet J-P, Jardetzky TS (1998) Crystal structure of the human high-affinity IgE receptor. Cell 95: 951–961

    Article  PubMed  CAS  Google Scholar 

  • Garman SC, Wurzburg BA, Tarchevskaya SS, Kinet JP, Jardetzky TS (2000) Structure of the Fc fragment of human IgE bound to its high-affinity receptor FcaRla. Nature 406: 259266

    Google Scholar 

  • Gergely J, Pecht I, Sarmay G (1999) Immunoreceptor tyrosine-based inhibition motif-bearing receptors regulate the immunoreceptor tyrosine-based activation motif-induced activation of immune competent cells. Immunol Lett 68: 3–15

    Article  PubMed  CAS  Google Scholar 

  • Gilles F, Goy A, Remache Y, Shue P, Zelenetz AD (2000) MUC1 dysregulation as the consequence of a t(1;14)(q21;q32) translocation in an extranodal lymphoma. Blood 95: 2930–2936

    PubMed  CAS  Google Scholar 

  • Guex N, Peitsch MC (1997) SWISS-MODEL and the Swiss-Pdb viewer: an environment for comparative protein modeling. Electrophoresis 18: 2714–2723

    Article  PubMed  CAS  Google Scholar 

  • Hatakeyama S, Osawa M, Omine M, Ishikawa F (1999) JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation. Oncogene 18: 2085–2090

    Article  PubMed  CAS  Google Scholar 

  • Hatzivassiliou G, Miller I, Takizawa J, Palanisamy N, Rao PH, Iida S, Tagawa S, Taniwaki M, Russo J, Neri A, Catoretti G, dynes R, Mendlsohn C, Chaganti RSK, Dalla-Favera, R (2001) IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. Immunity 14: 277–289

    Article  PubMed  CAS  Google Scholar 

  • Hayami K, Fukuta D, Nishikawa Y, Yamashita Y, Inu M, Ohyama Y, Hikida M, Ohmori H, Takai T (1997) Molecular cloning of a novel murine cell surface glycoprotein homologous to killer cell inhibitory receptors. J Biol Chem 272: 7320–7327

    Article  PubMed  CAS  Google Scholar 

  • Henry C, Jerne NK (1968) Competition of 19 S and 7 S antigen receptors in the regulation of the primary immune response. J Exp Med 128: 133–152

    Article  PubMed  CAS  Google Scholar 

  • Heyman B (1999) Antibody feedback suppression: towards a unifying concept? Immunol Lett 68: 41–45

    Article  PubMed  CAS  Google Scholar 

  • Heyman B (2000) Regulation of antibody responses via antibodies, complement, and Fc receptors. Annu Rev Immunol 18: 709–737

    Article  PubMed  CAS  Google Scholar 

  • Hibbs ML, Selvaraj P, Carpen O, Springer TA, Kuster H, Jouvin MH, Kinet JP (1989) Mechanisms for regulating expression of membrane isoforms of Fc gamma RIII (CD16). Science 246: 1608–1611

    Article  PubMed  CAS  Google Scholar 

  • Ho LH, Uehara T, Chen CC, Kubagawa H, Cooper MD (1999) Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B. Proc Natl Acad Sci USA 96: 15086–15090

    Article  PubMed  CAS  Google Scholar 

  • Hulett MD, Witort E, Brinkworth RI, McKenzie IFC, Hogarth PM (1995) Multiple regions of human FcyRII (CD32) contribute to the binding of IgG. J Biol Chem 270: 21188–21194

    Article  PubMed  CAS  Google Scholar 

  • Johansson B, Mertens F, Mitelman F (1995) Cytogenetic evolution patterns in non-Hodg-kin’s lymphoma. Blood 86: 3905–3914

    PubMed  CAS  Google Scholar 

  • Kasahara M (1999) The chromosomal duplication model of the major histocompatibility complex. Immunol Rev 167: 17–32

    Article  PubMed  CAS  Google Scholar 

  • Kleinau S, Martinsson P, Heyman B (2000) Induction and suppression of collagen-induced arthritis is dependent on distinct FcyR. J Exp Med 191: 1611–1616

    Article  PubMed  CAS  Google Scholar 

  • Krajci P, Grzeschik KH, Geurts van Kessel AH, Olaisen B, Brandtzaeg P (1991) The human transmembrane secretory component (poly-Ig receptor): molecular cloning, restriction fragment length polymorphism and chromosomal sublocalization. Hum Genet 87: 642–648.

    Article  PubMed  CAS  Google Scholar 

  • Kremer EJ, Kalatzis V, Baker E, Callen DF, Sutherland GR, Maliszewski CR (1992) The gene for the human IgA Fc receptor maps to 19q13.4. Hum Genet 89: 107–108

    Article  PubMed  CAS  Google Scholar 

  • Kubagawa H, Burrows P, Cooper MD (1997) A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Proc Natl Acad Sci USA 94: 5261–5266

    Article  PubMed  CAS  Google Scholar 

  • Kulczycki A Jr, Webber J, Soares HA, Onken MD, Thompson JA, Chaplin DD, Loh DY (1990) Genomic organization of the mouse Fcy receptor genes. Proc Natl Acad Sci USA 87: 2856–2860

    Article  PubMed  CAS  Google Scholar 

  • Kuppers R, Klein U, Hansmann ML, Rajewsky K (1999) Cellular origin of human B-cell lymphomas. N Engl J Med 341: 1520–1529

    Article  PubMed  CAS  Google Scholar 

  • Lanier LL (1998a) NK cell receptors. Annu Rev Immunol 16: 359–393

    Article  PubMed  CAS  Google Scholar 

  • Lanier LL (1998b) Follow the leader: NK cell receptors for classical and non-classical MHC class I. Cell 92: 705–707

    Article  PubMed  CAS  Google Scholar 

  • Long EO (1999) Regulation of immune responses through inhibitory receptors. Annu Rev Immunol 17: 875–904

    Article  PubMed  CAS  Google Scholar 

  • Maxwell KF, Powell MS, Hulett MD, Barton PA, McKenzie IF, Garrett TP, Hogarth PM (1999) Crystal structure of the human leukocyte Fc receptor, FcyRIIA. Nat Struct Biol 6: 437–442

    Google Scholar 

  • Moretta A, Bottino C, Vitale M, Pende D, Biassoni R, Mingari MC, Moretta L (1996) Receptors for HLA class-I molecules in human natural killer cells. Annu Rev Immunol 14: 619–648

    Article  PubMed  CAS  Google Scholar 

  • Morton HC, Zandbergen van G, Kooten van C, Howard CJ, Winkel van de JG, Brandtzaeg P (1999) Immunoglobulin-binding sites of human FcaRI (CD89) and bovine Fcy2R are located in their membrane-distal extracellular domains. J Exp Med 189: 17151722

    Google Scholar 

  • Morton HC, Van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJA, Winkel van de JGJ (1995) Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcRy chain. Molecular basis for CD89/FcRy chain association. J Biol Chem 270: 29781–29787

    Article  PubMed  CAS  Google Scholar 

  • Nakamura A, Yuasa T, Ujike A, Ono M, Nukiwa T, Ravetch JV, Takai T (2000) FcyRIIBdeficient mice develop Goodpasture’s syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease. J Exp Med 191: 899–906

    Article  PubMed  CAS  Google Scholar 

  • Nicholas KB, Nicholas HB Jr, Deerfield DW II (1997) EMBnet News 4: 14

    Google Scholar 

  • Oakley RJ, Howard TA, Hogarth PM, Tani K, Seldin MF (1992) Chromosomal mapping of the high affinity Fey receptor gene. Immunogenetics 35: 279–282

    Article  Google Scholar 

  • Offit K, Wong G, Filippa DA, Tao Y, Chaganti RS (1991) Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin’s lymphoma: clinical correlations. Blood 77: 1508–1515

    PubMed  CAS  Google Scholar 

  • Ohno T, Kubagawa H, Sanders SK, Cooper MD (1990) Biochemical nature of an Felt receptor on human B-lineage cells. J Exp Med 172: 1165–1175

    Article  PubMed  CAS  Google Scholar 

  • Ono M, Bolland S, Tempst P, Ravetch JV (1996) Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB Nature 383: 263–266

    CAS  Google Scholar 

  • Pang J, Taylor GR, Munroe DG, Ishaque A, Fung-Leung WP, Lau CY, Liu FT, Zhou L (1994) Characterization of the gene for the high affinity IgE receptor ( FccRI) a-chain. J Immunol 151: 6166–6174

    Google Scholar 

  • Pascual V, Liu Y-J, Magalski A, de Bouteiller O, Bancereau J, Capra JD (1994) Analysis of somatic mutation in five B cell subsets of human tonsil. J Exp Med 180: 329–339

    Article  PubMed  CAS  Google Scholar 

  • Perez-Montfort R, Kinet JP, Metzger H (1983) A previously unrecognized subunit of the receptor for immunoglobulin E. Biochemistry 22: 5722–5728

    Article  CAS  Google Scholar 

  • Pfefferkorn LC, Yeaman GR (1994) Association of IgA-Fc receptors (FcaR) with FcaRIy2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of y2. J Immunol 153: 3228–3236

    PubMed  CAS  Google Scholar 

  • Pleass RJ, Dunlop JI, Anderson CM, Woof JM (1999) Identification of residues in the CH2/ CH3 domain interface of IgA essential for interaction with the human Fca receptor (FcaR) CD89. J Biol Chem 274: 23508–23514

    Article  PubMed  CAS  Google Scholar 

  • Qui WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (1990) Organization of the human and mouse low-affinity FcyR genes: amplification and recombination Science 248: 732–735

    Google Scholar 

  • Ravetch JV, Kinet J-P (1991) Fc receptors. Annu Rev Immunol 9: 457–492

    Article  CAS  Google Scholar 

  • Ravetch JV, Clynes RA (1998) Divergent roles for Fc receptors and complement in vivo. Annu Rev Immunol 16: 421–432

    Article  PubMed  CAS  Google Scholar 

  • Ravetch JV, Lanier LL (2000) Immune inhibitory receptors. Science 290:84–89 Ravetch JV, Bolland S (2001) IgG Fc receptors. Annu Rev Immunol 19:275–290 Reth M (1992) Antigen receptors on B lymphocytes. Annu Rev Immunol 10: 97–121

    Google Scholar 

  • Samaridis J, Colonna M (1997) Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: Structural evidence for new stimulatory and inhibitory pathways. Eur J Immunol 27: 660–665

    Google Scholar 

  • Sanders SK, Kubagawa H, Suzuki T, Butler JL, Cooper MD (1987) IgM binding protein expressed by activated B cells. J Immunol 139: 188–193

    PubMed  CAS  Google Scholar 

  • Scholl PR, Geha RS (1993) Physical association between the high-affinity IgG receptor (Fc gamma RI) and the gamma subunit of the high-affinity IgE receptor ( Fc epsilon RI gamma ). Proc Natl Acad Sci USA 90: 8847–8850

    Google Scholar 

  • Selvakumar A, Steffens U, Palansami N, Chaganti RS, Dupont B (1997) Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR103. Tissue Antigens 49: 564–573

    Article  PubMed  CAS  Google Scholar 

  • Shibuya A, Sakamoto N, Shimizu Y, Shibuya K, Osawa M, Hiroyama T, Eyre HJ, Sutherland GR, Endo Y, Fujita T, et al (2000) Fc alpha/mu mediates endocytosis of IgM-coated microbes. Nature Immunol 1: 441–446

    Article  CAS  Google Scholar 

  • Sondermann P, Huber R, Jacob U (1999) Crystal structure of the soluble form of the human FcyRIIB: a new member of the immunoglobulin superfamily at 1.7 A resolution. Embo J 18: 1095–1103

    Article  PubMed  CAS  Google Scholar 

  • Sondermann P, Kaiser J, Jacob U (2001) Molecular Basis for Immune Complex Recognition: a comparison of Fc-receptor Structures. J Mol Biol 309: 737–749

    Article  PubMed  CAS  Google Scholar 

  • Sondermann P, Huber R, Oosthuizen V, Jacob U (2000) The 3.2-A crystal structure of the human IgG1 Fc fragment-FcyRI1I complex. Nature 406: 267–273

    Article  PubMed  CAS  Google Scholar 

  • Sylvestre DL, Ravetch JV (1996) A dominant role for mast cell Fc receptor in the Arthus reaction. Immunity 5: 387–390

    Article  PubMed  CAS  Google Scholar 

  • Tamm A, Schmidt RE (1997) IgG binding sites on human Fey receptors. Int Rev Immunol 16: 57–85

    Article  PubMed  CAS  Google Scholar 

  • Tepler I, Morton CC, Shimizu A, Holcombe RF, Eddy R, Shows TB, Leder P (1989) The gene for the human mast cell high-affinity IgE receptor alpha chain: chromosomal locaticalization to 1q21- of 23 and RFLP analysis. Am J Hum Genet 45: 761–765

    PubMed  CAS  Google Scholar 

  • Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG (1997) The CLUSTALX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 25: 4876–4882

    Article  PubMed  CAS  Google Scholar 

  • Torkar M, Norgate Z, Colonna M, Trowsdale J, Wilson MJ (1998) Isotypic variation of the novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex. Eur J Immunol 28: 3959–3967

    Article  PubMed  CAS  Google Scholar 

  • Tse W, Zhu W, Chen HS, Cohen A (1995) A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cells. Blood 85: 650–656

    PubMed  CAS  Google Scholar 

  • Unkeless JC, Jin J (1997) Inhibitory receptors, ITIM sequences and phosphatases. Curr Opin Immunol 9: 338–343

    Google Scholar 

  • Van de Peer Y, De Wachter R (1993) TREECON: a software package for the construction and drawing of evolutionary trees. Comp Appl Biosci 9: 177–182

    PubMed  Google Scholar 

  • Vely F, Vivier E (1997) Conservation of structural features reveals the existence of a large family of inhibitory cell surface receptors and noninhibitory/activatory counterparts. J Immunol 159: 2075–2077

    PubMed  CAS  Google Scholar 

  • Wagtmann N, Rojo S, Eichler E, Mohrenweiser H, Long EO (1997) A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors. Curr Biol 7: 615–618

    Article  PubMed  CAS  Google Scholar 

  • Wende H, Colonna M, Ziegler A, Volz A (1999) organization of the leukocyte receptor cluster (LRC) on human chromosome 19813.4. Mamm Genome 10: 154–160

    Google Scholar 

  • Whang-Peng J, Knutsen T, Jaffe ES, Steinberg SM, Raffeld M, Zhao WP, Duffey P, Condron K, Yano T, Longo DL (1995) Sequential analysis of 43 patients with non-Hodgkin’s lymphoma: clinical correlations with cytogenetic, histologic, immunophenotyping, and molecular studies. Blood 85: 203–216

    PubMed  CAS  Google Scholar 

  • Williams AF, Barclay AN (1988) The immunoglobulin superfamily-domains for cell surface recognition. Annu Rev Immunol 6: 381–405

    Article  PubMed  CAS  Google Scholar 

  • Willis TG, Zalcberg IR, Coignet LJ, Wlodarska I, Stul M, Jadayel DM, Bastard C, Treleaven JG, Catovsky D, Silva ML, Dyer MJ (1998) Molecular cloning of translocation t(1;14)(g21;g32) defines a novel gene (BCL9) at chromosome 1q21. Blood 91: 1873–1881

    PubMed  CAS  Google Scholar 

  • Wilson MJ, Torkar M, Trowsdale J (1997) Genomic organization of a human killer cell inhibitory receptor gene Tissue Antigens 49: 574–579

    CAS  Google Scholar 

  • Wilson MJ, Torkar M, Haude A, Milne S, Jones T, Sheer D, Beck S, Trowsdale J (2000) Plasticity in the organization and sequences of human KIR/ILT gene families. Proc Natl Acad Sci USA 97: 4778–4783

    Article  PubMed  CAS  Google Scholar 

  • Winkel van de JG, Capel PJ (1993) Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol Today 14: 215–221

    Article  Google Scholar 

  • Wit de TPM, Morton HC, Capel PJA, Winkel van de JGJ (1995) Structure of the gene for the human myeloid IgA Fc receptor (CD89). J Immunol 155: 1203–1209

    PubMed  Google Scholar 

  • Xu M, Zhao R, Zhao ZJ (2001) Molecular cloning and characterization of SPAP1, an inhibitory receptor. Biochem Biophys Res Commun 280: 768–775

    Article  PubMed  CAS  Google Scholar 

  • Ye ZS, Kinet JP, Paul WE (1992) Structure of the gene for the a-chain of the mouse high affinity receptor for IgE ( FcERI ). J Immunol 149: 897–900

    Google Scholar 

  • Yuasa T, Kubo S, Yoshino T, Ujike A, Matsumura K, Ono M, Ravetch JV, Takai T (1999) Deletion of FcyIIB renders H-2(b) mice susceptible to collagen-induced arthritis. J Exp Med 189: 187–194

    Article  PubMed  CAS  Google Scholar 

  • Zhang G, Young JR, Tregaskes CA, Sopp P, Howard CJ (1995) Identification of a novel class of mammalian FcyR. J Immunol 155: 1534–1541

    PubMed  CAS  Google Scholar 

Download references

Author information

Author notes

  1. G. Dennis Jr.

    Present address: Laboratory of Immunopathogenesis and Bioinformatics, Clinical Services Program, National Institute of Allergy and Infectious Disease, Science Applications International Corporation-Frederick, MD, USA

Authors and Affiliations

  1. Division of Hematology/Oncology and Department of Medicine, University of Alabama at Birmingham, AL, 35294-3300, USA

    R. S. Davis

  2. Department of Microbiology, University of Alabama at Birmingham, AL, 35294-3300, USA

    G. Dennis Jr.

  3. Department of Pathology, University of Alabama at Birmingham, AL, 35294-3300, USA

    H. Kubagawa

  4. Howard Hughes Medical Institute, University of Alabama at Birmingham, 378 Wallace Tumor Institute, Birmingham, AL, 35294, USA

    M. D. Cooper

Authors
  1. R. S. Davis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Dennis Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Kubagawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. D. Cooper
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Howard Hughes Medical Institute Research Laboratories, University of Alabama at Birmingham, 378 Wallace Tumor Institute, 35294, Birmingham, Alabama, USA

    Max D. Cooper

  2. Department of Microbiology and Immunology Center for Neurobiology, Jefferson Alumni Hall, Jefferson Medical College, 1020 Locust Street, 19197-6799, Philadelphia, PA, USA

    Hilary Koprowski

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Davis, R.S., Dennis, G., Kubagawa, H., Cooper, M.D. (2002). Fc Receptor Homologs (FcRH1-5) Extend the Fc Receptor Family. In: Cooper, M.D., Koprowski, H. (eds) The Interface Between Innate and Acquired Immunity. Current Topics in Microbiology and Immunology, vol 266. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04700-2_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-04700-2_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-07682-4

  • Online ISBN: 978-3-662-04700-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation