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The Berlin “Protein Structure Factory” Initiative: A Technology-Oriented Approach to Structural Genomics

  • Conference paper
Data Mining in Structural Biology

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 34))

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Abstract

The Ernst Schering Research Foundation Workshop 34 on Data Mining in Structural Biology: Signal Transduction and Beyond, which served as the basis for this volume, coincided almost perfectly with the public announcement of a “working draft” of the human genome sequence (Macilwaine 2000). This major publicity event followed closely completion of the DNA sequencing of the two smallest human chromosomes (Dunham et al. 1999; Hattori et al. 2000). In addition, a rapidly growing number of DNA sequences representing complete genomes from all kingdoms of life is known. It is anticipated that these landmark achievements will have a major impact on medicine and pharmacology (Roses 2000; Sander 2000). However, new insight does not flow directly from genomic sequences: Computer-assisted (Bork and Eisenberg 1998; Enright et al. 1999; Marcotte et al. 1999; Šali 1999; Eisenberg et al. 2000) and experimental approaches (Gerhold et al. 1999; Lockhart and Winzeler 2000; Oliver 2000; Pandey and Mann 2000; Roberts et al. 2000; Uetz et al. 2000) need to be developed and are, indeed, being developed in order to complement the vast amount of genomic information with the corresponding data pertaining to the gene products and their interactions.

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  1. U. Heinemann
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  1. Department of Biophysical Chemistry, Max-Planck-Institute for Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany

    I. Schlichting

  2. Research Laboratories, Schering AG, Müllerstrasse 178, 13342, Berlin, Germany

    U. Egner

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Heinemann, U. (2001). The Berlin “Protein Structure Factory” Initiative: A Technology-Oriented Approach to Structural Genomics. In: Schlichting, I., Egner, U. (eds) Data Mining in Structural Biology. Ernst Schering Research Foundation Workshop, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04645-6_6

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  • DOI: https://doi.org/10.1007/978-3-662-04645-6_6

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