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Data Mining in Structural Biology pp 81–99Cite as

Elements of Signal Transduction in Drug Discovery with Special Reference to Inhibitors of Protein Kinase C

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Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 34))

Abstract

Although for a few malignancies, such as childhood leukaemia, Hodgkin’s disease, and testicular cancer, impressive progress has been achieved, cancer mortality as a whole has remained almost unchanged during the last two decades despite enormous worldwide efforts. This is particularly surprising in view of the tremendous progress that has been achieved during the last 20–25 years with regard to our understanding of the molecular mechanisms underlying the regulation of normal growth and dysregulation of malignant growth. Major scientific breakthroughs — the discovery of oncogenes, tumour suppressor genes, mechanisms of angiogenesis, and apoptosis — have occurred during the last two to three decades, but these have not led to any major progress in cancer treatment.

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Authors
  1. H. H. Grunicke
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  2. S. Kampfer
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  3. M. Spitaler
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  4. F. Hochholdinger
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  5. G. Baier
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  6. F. Überall
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Editors and Affiliations

  1. Department of Biophysical Chemistry, Max-Planck-Institute for Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany

    I. Schlichting

  2. Research Laboratories, Schering AG, Müllerstrasse 178, 13342, Berlin, Germany

    U. Egner

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© 2001 Springer-Verlag Berlin Heidelberg

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Grunicke, H.H., Kampfer, S., Spitaler, M., Hochholdinger, F., Baier, G., Überall, F. (2001). Elements of Signal Transduction in Drug Discovery with Special Reference to Inhibitors of Protein Kinase C. In: Schlichting, I., Egner, U. (eds) Data Mining in Structural Biology. Ernst Schering Research Foundation Workshop, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04645-6_5

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  • DOI: https://doi.org/10.1007/978-3-662-04645-6_5

  • Publisher Name: Springer, Berlin, Heidelberg

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  • Online ISBN: 978-3-662-04645-6

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