Abstract
In the last 25 years, extensive progress has been made in the prenatal diagnosis of congenital diseases using non-invasive and invasive techniques. In contrast to prenatal diagnosis, prenatal therapy has shown limited success so far. Therefore, if a severe congenital disease is diagnosed early in gestation, many parents choose to terminate pregnancy. Prenatal transfer of hematopoietic stem cells (HSC) is a promising approach to successfully treat fetuses affected by hematologic, immunologic, or metabolic diseases. Recently, clinical success has been achieved (Flake et al. 1996). The success, however, is limited to diseases where severe immunodeficiency is present in the fetus. This article aims to provide an overview of the current experience in animals and humans and to identify strategies to overcome the current obstacles.
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References
Almeida-Porada G, Flake AW, Glimp HA, Zanjani ED (1999) Cotransplantation of stroma results in enhancement and early expression of donor hematopoietic stem cells in utero. Exp Hematol 27: 1569–1575
Elwood ET, Larsen CP, Maurer DH et al (1998) Microchimerism and rejection in clinical transplantation. Lancet 349: 1358–1360
Flake AW, Zanjani ED (1999) In utero hematopoietic stem cell transplantation: ontogenetic opportunities and biologic barriers. Blood 94: 2179–2191
Flake AW, Roncarolo MG, Puck JM et al (1996) Treatment of X-linked severe combined immunodeficiency by in utero transplantation of paternal bone marrow. N Engl J Med 335: 1806–1810
Surbek DV, Holzgreve W, Jansen W et al (1998) Quantitative immunophenotypic characterization, cryopreservation, and enrichment of second and third trimester human fetal cord blood hematopoietic stem/progenitor cells. Am J Obstet Gynecol 179: 1228–1233
Surbek DV, Gratwohl A, Holzgreve W (1999) In utero hematopoietic stem cell transfer: current status and future strategies. Eur J Obstet Gynecol Reprod Biol 85: 109–115
Thilaganathan B, Nicolaides KH (1993) Intrauterine bone-marrow transplantation at 12 weeks’ gestation. Lancet 342: 243
Zanjani ED, Anderson WF (1999) Prospects for in utero human gene therapy. Science 285: 2084–2088
Zanjani ED, Flake AW, Almeida-Porada G, Tran N, Papayannopoulou T (1999) Homing of human cells in fetal sheep model: modulation by anti-bodies activating or inhibiting very late activation antigen-4-dependent function. Blood 94: 2515–2522
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© 2001 Springer-Verlag Berlin Heidelberg
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Surbek, D.V., Holzgreve, W. (2001). Prenatal Transplantation of Hematopoietic Stem Cells: Overview. In: Holzgreve, W., Lessl, M. (eds) Stem Cells from Cord Blood, in Utero Stem Cell Development and Transplantation-Inclusive Gene Therapy. Ernst Schering Research Foundation Workshop, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04469-8_8
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DOI: https://doi.org/10.1007/978-3-662-04469-8_8
Publisher Name: Springer, Berlin, Heidelberg
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