Abstract
Cellular homeostasis of various solid tissues as well as those composed of single cells such as skin, intestine and the haematopoietic system is maintained by a hierarchical structured cell system, with stem cells as their cellular origin. Stem cells are functionally defined by their capacity to self-renew and to lead to multi-lineage differentiation; hence, stem cells have the ability to generate both new stem cells and to clonally regenerate all the different cell types that constitute a stem cell system.
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Müller, A.M., Geiger, H., Eichholz, G., Harder, F. (2001). Origin and Developmental Plasticity of Haematopoietic Stem Cells. In: Holzgreve, W., Lessl, M. (eds) Stem Cells from Cord Blood, in Utero Stem Cell Development and Transplantation-Inclusive Gene Therapy. Ernst Schering Research Foundation Workshop, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04469-8_3
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DOI: https://doi.org/10.1007/978-3-662-04469-8_3
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