Strategies in Lead Selection and Optimization: Application of a Graphical Model and Automated In Vitro ADME Screening

  • A. K. Mandagere
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 37)


The drug discovery process in the pharmaceutical industry has undergone a dramatic change in the last decade due to advances in molecular biology, high-throughput pharmacological screens and combinatorial synthesis. In addition, the high cost, the long development time and the high failure rate in bringing drugs to market have also been the driving forces behind this change. The convergence of computational power, information management, robotics and automation technologies have aided in the dramatic acceleration in the pace of early drug discovery.


Oral Bioavailability Metabolic Stability Hepatic Extraction Ratio Absolute Oral Bioavailability Lead Selection 
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© Springer-Verlag Berlin Heidelberg 2002

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  • A. K. Mandagere

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