Strategies in Lead Selection and Optimization: Application of a Graphical Model and Automated In Vitro ADME Screening
The drug discovery process in the pharmaceutical industry has undergone a dramatic change in the last decade due to advances in molecular biology, high-throughput pharmacological screens and combinatorial synthesis. In addition, the high cost, the long development time and the high failure rate in bringing drugs to market have also been the driving forces behind this change. The convergence of computational power, information management, robotics and automation technologies have aided in the dramatic acceleration in the pace of early drug discovery.
KeywordsOral Bioavailability Metabolic Stability Hepatic Extraction Ratio Absolute Oral Bioavailability Lead Selection
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