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In Vitro Screening of Cytochrome P450 Induction Potential

  • O. Pelkonen
  • J. Hukkanen
  • P. Honkakoski
  • J. Hakkola
  • P. Viitala
  • H. Raunio
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 37)

Abstract

Induction is defined as the increase in the amount and activity of a drug-metabolising enzyme, which is a long-term (hours and days) consequence of a chemical exposure. Previously, the study of induction of drug metabolism was largely empirical and phenomenological, and prediction beyond the compounds under actual study was practically impossible. During the last decade, however, and particularly as a consequence of the detailed knowledge obtained about regulatory factors governing the expression and induction of cytochrome P450 (CYP) enzymes, induction can be understood on a detailed mechanistic basis and predictability of pharmacological and toxicological consequences has become possible. Mechanistic understanding provides also a basis for the development of new in vitro methods to measure and predict induction.

Keywords

Glucocorticoid Receptor Nuclear Receptor Human Hepatocyte Primary Hepatocyte Aryl Hydrocarbon Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • O. Pelkonen
  • J. Hukkanen
  • P. Honkakoski
  • J. Hakkola
  • P. Viitala
  • H. Raunio

There are no affiliations available

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