Antiphospholipid Syndrome

  • P. G. Vlachoyiannopoulos
  • H. M. Moutsopoulos


Antiphospholipid (anticardiolipin) syndrome (APS) is a chronic disorder associated with recurrent venous and/or arterial thrombosis, recurrent abortions, thrombocytopenia and/or autoimmune hemolytic anemia and positive results are obtained from tests for antiphospholipid antibodies (aPL) and/or lupus anticoagulant (LA). The disease can occur alone (primary APS) or in association with other systemic autoimmune diseases, especially systemic lupus erythematosus (SLE), (secondary APS).


Anticardiolipin Syndrome 


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  1. 1.
    Haris EN (1997) “Management of the antiphospholipid syndrome. In: van de Putte LBA, Furst DE, Williams H), van Riel PLCM (eds) Therapy of systemic rheumatic disorders. Marcel Dekker, New York 33:629–656Google Scholar
  2. 2.
    Rosove MH, Brewer PMC (1992) Antiphospholipid thrombosis: clinical course after the first thrombotic event in 70 patients. Ann Intern Med 17: 303–308CrossRefGoogle Scholar
  3. 3.
    Sturtelt G, Mousa F, Jonsson H et al. (1990) Recurrent cerebral infarction and the antiphospholipid syndrome: effect of intravenous gammaglobulin in a patient with systemic lupus erythematosous. Ann Rheum Dis 49: 939–941CrossRefGoogle Scholar
  4. 4.
    Roach BA, Hutchinson GJ (1993) Treatment of refractory, systemic lupus erythematosus–associated thrombocytopenia with intermittent low dose intravenous cyclophosphamide. Artritis Rheum 36: 682–684CrossRefGoogle Scholar
  5. 5.
    Laskin CA, Bombardier C, Hannah M et al. (1997) Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss. N Engl J Med 337: 148–152PubMedCrossRefGoogle Scholar
  6. 6.
    Vlachoyiannopoulos PG, Tsiakou E, Chalevelakis G, Raptis SA, Moutsopoulos HM (1993) Antiphospolipid syndrome: Clinical and therapeutic aspects. Lupus 3: 91–96CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • P. G. Vlachoyiannopoulos
  • H. M. Moutsopoulos

There are no affiliations available

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