Abstract
The approval of interferon-β lb for the treatment of multiple sclerosis (MS) in 1993 has had a profound impact on the attitude of both physicians and patients concerning the illness. To fully appreciate the impact one needs to understand the failures of previous therapies and the frustration associated with dealing with a disease of uncertain prognosis and course. The approval of interferon-β 1b opened a new era of treatment of and research on MS. In this review I will examine the natural history of the disease in order for the reader to understand the difficulties associated with the care of patients with MS and in identifying new therapies for the disease. I will then discuss the impact of that approval and the current thoughts on treatment MS.
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References
Weinshenker BG (1994) Natural history of multiple sclerosis. Ann Neurol 36 [Suppl]: S6–11
McFarland HF (1998) The lesion in multiple sclerosis: clinical, pathological, and magnetic resonance imaging considerations. J Neurol Neurosurg Psychiatry 64 [Suppl 1]: S26–30
Frank JA et al (1994) Serial contrast-enhanced magnetic resonance imaging in patients with early relapsing-remitting multiple sclerosis: implications for treatment trials. Ann Neurol 36 [Suppl]: S86–90
Molyneux PD et al (1998) Correlations between monthly enhanced MRI lesion rate and changes in T2 lesion volume in multiple sclerosis. Ann Neurol 43: 332–339
Stone LA et al (1995) Blood-brain barrier disruption on contrast-enhanced MRI in patients with mild relapsing-remitting multiple sclerosis: relationship to course, gender, and age. Neurology 45: 1122–1126
Thorpe JW et al (1996) Serial gadolinium-enhanced MRI of the brain and spinal cord in early relapsing-remitting multiple sclerosis. Neurology 46: 373–378
McFarland HF et al (1992) Using gadolinium-enhanced magnetic resonance imaging lesions to monitor disease activity in multiple sclerosis. Ann Neurol 32: 758–766
Miller DH et al (1998) The role of magnetic resonance techniques in understanding and managing multiple sclerosis. Brain 121: 3–24
Filippi M et al (1994) Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis. Neurology 44: 635–641
O’Riordan J et al (1998) The prognostic value of brain MRI in clinically isolated syndromes of the CNS. A 10-year follow-up. Brain 121: 495–503
Optic Neuritis Study Group (1997) The 5-year risk of MS after optic neuritis. Experience of the optic neuritis treatment trial. Optic Neuritis Study Group [see comments]. Neurology 49: 1404–1413
Smith ME et al (1993) Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine-enhancing magnetic resonance imaging lesions. Ann Neurol 33: 480–489
Jacobs L, O’Malley J, Freedman A, Ekes R (1981) Intratrhecal interferon reduces exacerbations in multiple sclerosis. Science 214: 1026–1028
The IFNB Multiple Sclerosis Study Group (1993) Interferon beta-lb is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 43: 655–661
Paty DW, Li DK (1993) Interferon beta-lb is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group [see comments]. Neurology 43: 662–667
Johnson K et al (1995) Glatiramer acetate reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multi-center, double blind, placebo controlled trial. Neurology 45: 1266–1276
Jacobs LD et al (1996) Intramuscular interferon beta-la for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG) [see comments; published erratum appears in Ann Neurol 1996; 40(3):480]. Ann Neurol 39: 285–294
Martin R, McFarland H (1996) Experimental immunotherapies for multiple sclerosis. Springer Semin Immunopathol 9: 1–24
Thompson A, Noseworthy J (1996) New treatments for multiple sclerosis: a clinical perspective. Curr Opin Neurol 9: 187–198
Stone LA et al (1995) The effect of interferon-beta on blood-brain barrier disruptions demonstrated by contrast-enhanced magnetic resonance imaging in relapsing-remitting multiple sclerosis. Ann Neurol 37: 611–619
Miller DH (1996) Guidelines for MRI monitoring of the treatment of multiple sclerosis: recommendations of the US Multiple Sclerosis Society’s task force. Mult Scler 1: 335–338
Stone LA et al (1997) Characterization of MRI response to treatment with interferon beta-lb: contrast-enhancing MRI lesion frequency as a primary outcome measure. Neurology 49: 862–869
Jacobs LD et al (1995) A phase III trial of intramuscular recombinant interferon beta as treatment for exacerbating-remitting multiple sclerosis: design and conduct of study and baseline characteristics of patients. Multiple Sclerosis Collaborative Research Group (MSCRG). Mult Scler 1: 118–135
PRISMS (1998) Randomised double-blind placebo-controlled study of interferon beta-la in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-la Subcutaneously in Multiple Sclerosis) Study Group. Lancet 352: 1498–1504
European Study Group on Interferon beta-lb in Secondary Progressive MS (1998) Placebo-controlled multicenter randomized trial of interferon beta-lb in treatment of secondary progressive multiple sclerosis. Lancet 352: 1491–1497
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McFarland, H.F. (1999). The Clinical and Social Impact of Interferon-β: The First Approved Therapy in Multiple Sclerosis. In: Lindenmann, J., Schleuning, WD. (eds) Interferon: The Dawn of Recombinant Protein Drugs. Ernst Schering Research Foundation Workshop, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03787-4_6
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DOI: https://doi.org/10.1007/978-3-662-03787-4_6
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