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Protection of Hematopoietic Progenitor Cells from Chemotherapy Toxicity by Transfer of Drug Resistance Genes

  • Conference paper
Gene Therapy

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 27))

  • 191 Accesses

Abstract

A major obstacle in eradicating unresectable or disseminated tumor cells with chemotherapy is thought to be due to inherent drug resistance, which in some instances may be overcome by the use of higher doses (Hryniuk and Bush 1984). Currently available chemotherapy, however, is often associated with various toxicities, in particular, bone marrow toxicity which is limiting for many of these agents. Use of recombinant hematopoietic growth factors or cytokines has enabled a modest increase in the dose chemotherapy that is tolerated. Most commonly used cytokines are granulocyte colony—stimulating factor (G—CSF) and granulocyte macrophage colony—stimulating factor (GM—CSF). Clinical trials using interleukin—3 (IL—3) and PIXY 321 (fusion protein of GM—CSF and IL—3) did not show a significant advantage over control groups (Ellis et al. 1996; Hofstra et al. 1997). Thrombopoietin, alone or in combination with other cytokines, is currently being evaluated in clinical trials. Another means of overcoming myelosuppression is the use of autologous bone marrow or peripheral stem cell transplantation after high doses of chemotherapy. This approach is currently being used in Hodgkin’s disease, breast and ovarian carcinomas (Bierman et al. 1993; Rosti et al. 1992; Reece et al. 1992; Chopra et al. 1993; Barnett et al. 1993).

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Authors
  1. N. Takebe
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  2. S.-C. Zhao
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  3. D. Banerjee
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  4. J. R. Bertino
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R. E. Sobol K. J. Scanlon E. Nestaas

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Takebe, N., Zhao, SC., Banerjee, D., Bertino, J.R. (1998). Protection of Hematopoietic Progenitor Cells from Chemotherapy Toxicity by Transfer of Drug Resistance Genes. In: Sobol, R.E., Scanlon, K.J., Nestaas, E. (eds) Gene Therapy. Ernst Schering Research Foundation Workshop, vol 27. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03577-1_8

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  • DOI: https://doi.org/10.1007/978-3-662-03577-1_8

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