Abstract
It is easily understood that behavioral psychopharmacology faced with the task of dealing with extremely complex behavioral disturbances of the elderly certainly has difficulties in designing up appropriate analogue models in experimental animals for human aging or the deficits occurring during human aging. One of the major problems for experimental behavioral pharmacology is whether or not old animals are the appropriate models. At the first view it seems obvious that the study of potential geronto-psychopharmacologic drugs should be performed in old animals. However, the problem is much more complicated. Laboratory animals are not a homogenous population, especially when old. Most of these old animals who are one third survivors of a population have an individually different pathological history which is mostly unknown to the investigators. Some animals may be arthritic others may have bronchitis or cardiac deficiencies. If, for example, an arthritic rat is given a performance task associated with lever pressing, the animals may fail because of his rigid and painful joints and not because of a brain deficit or of the ineffectiveness of the test compound. Similar effects can be observed with old animals having a cataract in a visual discrimination task. Failure to perform a task may even be the result of both central and peripheral disturbances. Consequently it is impossible to describe the failure of one animal to perform the task to deficits in some parts of the brain or to pathological changes in the body.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bartus RT, Dean RL, Beer B (1980) Memory deficits in aged cebus monkeys and facilitation with central cholinomimetics. Neurobiol Aging 1: 145–152
Bartus RT, Dean RL, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217: 408–417
Bartus RT, Dean RL, Flicker C (1987) Cholinergic psycho-pharmacology: an integration of human and animal research on memory. In: Meltzer HY (ed) Psychopharmacology: The Third Generation of Progress. Raven Press, New York, pp 219–232
Campbell BA, Spear NE (1972) Ontogeny of memory. Psycho! Rev 79: 215–236
Christie JE, Shering A, Ferguson J, Glen AIM (1981) Physostigmine and arecoline: Effects of intravenous infusions in Alzheimer presenile dementia. Br J Psychiatry 138: 46–50
Craik FJM (1977) Age differences in human memory. In: Birren JE, Schaie KW (eds., Handbook of the Psychology of Aging, Von Nostrand Reinhold Co., New York, NY, pp 384–420
Davis KL, Mohs RC (1982) Enhancement of memory proc- esses in Alzheimer’s disease with multiple dose intrave-nous physostigmine. Am J Psychiatry 139: 1421–1424
Fisher A, Hanin I (1986) Potential animal models for senile dementia of Alzheimer’s type, with emphasis on AF64A-induced cholinotoxicity. Ann Rev Pharmacol Toxicol 26: 161–181
Giurgea C, Mouravieff-Lesiusse F (1971) Pharmacological studies on an elementary model of learning - The fixation of an experience at spinal level: Part I: Pharmacological reactivity of the spinal cord fixation time. Arch Int Pharmacodyn 191: 279–291
Giurgea C, Salama M (1977) Nootropic drugs. Progr NeuroPsychopharmac 1: 235–247
Gold PE, McGaugh JL (1975) Changes in learning and memory during aging, In: Ordy JM, Brizzee KR (eds.), Neurobiology of Aging, Plenum Press, New York, NY, pp 145–158
Gold PE, van Buskirk RB, McGaugh JL (1975) Age-related changes in learning and memory. In: Maletta G (ed.), A Survey Report on the Aging Nervous System, US Government Printing Office, Washington, DC, pp 169–178
Hess EH (1972) “Imprinting” in a natural laboratory. Scientific American 227:24–31
Hock FJ (1987) Drug influences on learning and memory in aged animals and humans. Neuropsychobiol 17: 145–160
Jarvik ME (1964) Techniques for evaluating the effects of drugs on memory. In: Nodin JH, Siegler PE (eds) Animal and Clinical Pharmacologic Techniques in Drug Evaluation. Year Book Medical Publ. Inc.; Chicago, pp 339–347
Kubanis P, Zornetzer SF (1981) Age-related behavioral and neurobiological changes: A review with emphasis on memory. Behay. neural Biol. 31: 115–172
Lennenberg E (1967) The Biological Foundations of Language. Wiley & Sons, New York, NY
Nordberg A (1990) Pharmacological modulation of transmitter activity in Alzheimer brains–an experimental model. In: Novel Therapeutic Strategies for Dementia Diseases. Acta Neur Scand, Suppl 129: 17–20
Scheich H (1987) Neural correlates of auditory filial imprinting. J Comp Physiol A 161: 605–619
Schindler U, Rush DK, Fielding S (1984) Nootropic drugs: Animal models for studying effects on cognition. Drug Devel Res 4: 567–576
Summers WE, Viesselman JO, March GM, Candelora K (1981) Use of THA in treatment of Alzheimer-like dementia. Pilot study in twelve patients. Biol Psychiatry 16: 145–153
Sunderland T, Tariot PN, Newhouse PA (1988) Differential responsitivity of mood, behavior, and cognition to cholinergic agents in elderly, neuropsychiatric populations. Brain Res. Rev 13: 371–389
Thal LJ, Fuld PA, Masur DM, Sharpless NS (1983) Oral physostigmine and lecithin improve memory in Alzheimer’s disease. Ann Neurology 13: 491–496
Thompson G (1983) Rodent models of learning and memory in aging research. In Walker RF, Cooper RL (eds) Experimental and Clinical Interventions in Aging. Marcel Dekker, Inc., New York and Basel, pp 261–278
Weidemann A, König G, Bunke D, Fischer P, Salbaum JM, Masters CL, Beyreuther K (1989) Identification, biogenesis, and localization of precursors of Alzheimer’s disease A4 amyloid protein. Cell 57: 115–126
Atak JR, Perry EK, Bonham JR, Perry RH, Tomlinson BE, Blessed G, Fairbairn A (1983) Molecular forms of acetyl-cholinesterase in senile dementia of Alzheimer type: selective loss of the intermediate (10S) form. Neurosci Lett 40: 199–204
Augustinsson KB (1971) Determination of activity of cholinesterases. In: Glick D (ed.) Methods of Biochemical Analysis, John Wiley & Sons, New York, pp 217–273
Chan SL, Shirachi DY, Bhargava HN, Gardner E, Trevor AJ (1972) Purification and properties of multiple forms of brain acetylcholinesterase. J Neurochem 19: 2747–2758
Cheng Y, Prusoff WH (1973) Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 percent inhibition (IC50) of an enzymatic reaction. Biochem Pharmacol 22: 3099–3108
Christie JE, Shering A, Ferguson J, Glen AIM (1981) Physostigmine and arecoline: Effects of intravenous infusions in Alzheimer presenile dementia. Br J Psychiatry 138: 46–50
Davis KL, Mohs RC (1982) Enhancement of memory processes in Alzheimer’s disease with multiple dose intravenous physostigmine. Am J Psychiatry 139: 1421–1424
Ellman GL, Courtney KD, Andres V, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7: 88–95
Grassi J, Vigny M, Massoulié J (1982) Molecular forms of acetylcholinesterase in bovine caudate nucleus and superior cervical ganglion: solubility properties and hydrophobic character. J Neurochem 38: 457–469
Koelle GB, Koelle FS, Friedenwald JS (1950) The effect of inhibition of specific and non-specific cholinesterase. J Pharmacol Exp Ther 100: 180–191
McIntosh CHS, Plummer DT (1973) Multiple forms of acetyl- cholinesterase from pig brain. Biochem J 133: 655–665
Nachmansohn D, Rothenberg MA (1945) Studies on cholinesterase 1. On the specificity of the enzyme in nerve tissue. J Biol Chem 158: 653–666
Rieger F, Vigny M (1976) Solubilization and physicochemical characterization of rat brain acetylcholinesterase: development and maturation of its molecular forms. J Neurochem 27: 121–129
Summers WE, Viesselman JO, March GM, Candelora K (1981) Use of THA in treatment of Alzheimer-like dementia. Pilot study in twelve patients. Biol Psychiatry 16: 145–153
Taylor P (1980) Anticholinesterase agents, In: Gilman AG, Goodman LS, Gilman A. (eds) The Pharmacological Basis of Therapeutics, MacMillan Publishing Company, New York, pp 100–119
Thal LJ, Fuld PA, Masur DM, Sharpless NS (1983) Oral physostigmine and lecithin improve memory in Alzheimer’s disease. Ann Neurology 13: 491–496
Trevor AJ, Gordon MA, Parker KK, Chan SL (1978) Acetylcholinesterases. Life Sci 23: 1209–1220
Chemnitius J-M, Haselmeyer K-H, Zech R (1983) Brain cholinesterases: Differentiation of target enzymes for toxic organophosphorus compounds. Biochem Pharmacol 32: 1693–1699
Ellman GL, Courtney KD, Andres V, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7: 88–95
Walker CH, Mackness MI (1983) Esterases: Problems of identification and classification. Biochem Pharmacol 32: 3265–3269
Christie JE, Shering A, Ferguson J, Glen AIM (1981) Physostigmine and arecoline: Effects of intravenous infusions in Alzheimer presenile dementia. Br J Psychiatry 138: 46–50
Davis KL, Mohs RC (1982) Enhancement of memory process in Alzheimer’s disease with multiple dose intravenous physostigmine. Am. J. Psychiatry 139: 1421–1424
Ellman GL, Courtney KD, Andres V, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7: 88–95
Heilbronn E (1961) Inhibition of cholinesterase by tetrahydroaminacrin. A Chem Scand 15: 1386–1390
Muller F, Dumez Y, Massoulié J (1985) Molecular forms and solubility of acetylcholinesterase during the embryonic development of rat and human brain. Brain Res 331: 295–302
O’Brien RD (1969) Phosphorylation and carbamylation of cholinesterase. Ann NY Acad Sci 160: 204–214
Sivam SP, Norris JC, Lim DK, Hoskins B, Ho IK (1983) Effect of acute and chronic cholinesterase inhibition with diisopropylfluorophosphate on mu scarinic, dopamine, and GABA receptors in the rat striatum. J Neurochem 40: 14141422
Steinberg GM, Mednick ML, Maddox J, Rice R, Cramer J (1975) A hydrophobic binding site in acetylcholinesterase. J Med Chem 18: 1056–1061
Summers WK, Majovski LV, Marsh GM, Tachiki K, Kling A (1986) Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type. New Eng J Med 315: 1241–1245
Taylor P (1980) Anticholinesterase agents, In: Gilman AG, Goodman LS, Gilman A (eds.) The Pharmacological Basis of Therapeutics MacMillan Publishing Co., New York,. pp 100–119
Thal LJ, Fuld PA, Masur DM, Sharpless NS (1983) Oral physostigmine and lecithin improve memory in Alzheimer’s disease. Ann Neurology 13: 491–496
Yamada S, Isogai M, Okudaira H, Hayashi R (1983) Correlation between cholinesterase inhibition and reduction in muscarinic receptors and choline uptake by repeated diisopropylfluorophosphate administration: antagonism by physostigmine and atropine. J Pharmacol Exp Ther 226: 519525
Damsa G, Westerink GHC, Horn AS (1985) A simple, sensitive, and economic assay for choline and acetylcholine using HPLC, an enzyme reactor, and an electrochemical detector. J Neurochem 45: 1649–1652
DeBelleroche JS, Gardiner IM (1982) Cholinergic action in the nucleus accumbens: Modulation of dopamine and acetylcholine release. Br J Pharmacol 75: 359–365
Drukarch B, Schepens E, Schoffelmeer ANM, Stoof JC (1989) Stimulation of D-2 dopamine receptors decreases the evoked in vitro release of [3H]-acetylcholine from rat neostriatum: Role of K. and Ca+2. J Neurochem 52: 1680–1685
Gibson GE, Peterson C (1981) Aging decreases oxidative metabolism and the release and synthesis of acetylcholine. J Neurochem 37: 978–984
Hadhazy P, Szerb JC (1977) The effect of cholinergic drugs on [3H] acetylcholine release from slices of rat hippocampus, striatum and cortex. Brain Res 123: 311–322
Harms HH, Wardeh G, Mulder AH (1979) Effects of adenosine on depolarization-induced release of various radiolabelled neurotransmitters from slices of rat corpus striatum. Neuropharmacol 18: 577–580
Israel M. Lesbats B (1982) Application to mammalian tissue of the chemoluminescent method for detecting acetylcholine. J Neurochem 39: 248–250
Jackson D, Stachowiak MK, Bruno JP, Zigmond MJ (1988) Inhibition of striatal acetylcholine release by endogenous serotonin. Brain Res 457: 259–266
James MK, Cubeddu LX (1984) Frequency-dependent muscarinic receptor modulation of acetylcholine and dopamine release from rabbit striatum. J Pharmacol Exp Ther 229: 98–104
James MK, Cubeddu LX (1987) Pharmacological characterization and functional role of muscarinic autoreceptors in the rabbit striatum. J Pharmacol Exp Ther 240: 203–214
Magnusson O, Nilsson LB, Westerlund D (1980) Simultaneous determination of dopamine, DOPC and homovanillic acid. Direct injections of supernatants from brain tissue homogenates in a liquid chromatography-electrochemical detection system. J Chromatogr 221: 237–247
Muramatsu M, Tamaki-Ohashi J, Usuki C, Araki H, Aihara H (1988) Serotonin-2 receptor-mediated regulation of release of acetylcholine by minaprine in cholinergic nerve terminal of hippocampus of rat. Neuropharmacol 27: 603–609
Nielsen JA, Johnston CA (1982) Rapid, concurrent analysis of dopamine, 5-hydroxytryptamine, their precursors and metabolites utilizing high performance liquid chromatography with electrochemical detection: analysis of brain tissue and cerebrospinal fluid. Life Sci 31: 2847–2856
Nishino N, Fuji Y, Kondo M, Shuntoh H, Fujiwara H, Tanaka C (1987) Effects of L-Threo-3,4,-dihydroxyphenylserine on efflux of monoamines and acetylcholine in guinea pig brain. J Pharmacol Exp Ther 242: 621–628
Parker EM, Cubeddu LX (1986) Effects of d-amphetamine and dopamine synthesis inhibitors on dopamine and acetylcholine neurotransmission in the striatum. I. Release in the absence of vesicular transmitter stores. J Pharmacol Exp Ther 237: 179–192
Raiteri M, Angelini F, Levi G (1974) A simple apparatus for studying the release of neurotransmitters from synaptosomes. Eur J Pharmacol 25: 411–414
Raiteri M, Marchi M, Maura G (1984) Release of catecholamines, serotonin, and acetylcholine from isolated brain tissue. In: Lajtha A (ed) Handbook of Neurochemistry, 2nd ed, Plenum Press New York, London, pp 431–462
Richardson IW, Szerb JC (1974) The release of labelled acetylcholine and choline from cerebral cortical slices stimulated electrically. Br J Pharmacol 52: 499–507
Robinson S (1983) Effect of 5HT-lesions on cholinergic neurons in the hippocampus, cortex and striatum. Life Sci 32: 345–353
Saijoh K, Fujiwara H, Tanaka C ( 1985 a) Influence of hypoxia on release and uptake of neurotransmitters in guinea pig striatal slices: Dopamine and acetylcholine. Jpn J Pharmacol 39: 529–539
Saijoh K, Fujiwara H, Tanaka C (1985 b) Influence of hypoxia on release and acetylation of [3H]choline in brain slices from adult and newborn guinea pigs. Neurosci Lett 58: 371–374
Schacht U, Leven M, Bäcker G (1977) Studies on brain metabolism of biogenic amines. Br J Clin Pharmacol 4: 77S - 87S
Sethy VH, Francis JW, Russell RR, Ruppel PL (1988) Dual effect of N-methyl-N-(1-methyl-4-pyrrolidino)-2-butyl) acetamide on release of (3H) acetylcholine from the rat hippocampal slices. Neuropharmacol 27: 1191–1195
Smith CP, Huger FP, Petko W, Kongsamut S (1994) HP 749 enhances calcium-dependent release of [3H]norepinephrine from rat cortical slices and synaptosomes. Neurochem Res 19: 1265–1270
Smith CP, Petko WW, Kongsamut S, Roehr JE, Effland RC, Klein HT, Huger FP (1984) Mechanisms for the increase in electrically-stimulated norepinephrine (NE) release from cortical slices by HP 749 [N-(n-propyl)-N-(4-pyridinyl)1H-indol-1-amine]. Drug Dev Res 32: 13–18
Smith CP, Petko WW, Kongsamut S, Roehr JE, Effland RC, Klein JT, Huger FP (1994) Mechanisms for the increase in electrically stimulated [3H]norepinephrine release from rat cortical slices by N-(n-propyl)-N-(4-pyridinyl)-1H-indol-Iamine. Drug Dev Res 32: 13–18
Spignoli G, Pedata F, Giovannelli L, Banfi S, Moroni F, Pepeu G (1986) Effect of oxiracetam and piracetam on central cholinergic mechanisms and active-avoidance acquisition. Clin Neuropharmacol 9: S39 — S47
Stadler S, Nesselhut T (1986) Simple and rapid measurement of acetylcholine and choline by HPLC and enzymatic-electrochemical detection. Neurochem Int 9: 127–129
Strittmatter H, Jackisch R, Hertting G (1982) Role of dopamine receptors in the modulation of acetylcholine release in the rabbit hippocampus. Naunyn-Schmiedeberg’s Arch. Pharmacol. 321: 195–200
Supavilai P, Karobath M (1985) Modulation of acetylcholine release from rat striatal slices by the GABA/benzodiazepine receptor complex. Life Sci 36: 417–426
Szerb JC, Hadhazy P, Dudar JC (1977) Release of [3H]-acetylcholine from rat hippocampal slices: Effect of septal lesion and of graded concentrations of muscarinic agonists and antagonists. Brain Res 128: 285–291
Wagner J, Palfreyman M, Zraika M (1979) Determination of DOPA, dopamine, DOPAC, epinephrine, norepinephrine, a-fluoromethylDOPA, and a-difluoromethylDOPA in various tissues of mice and rats using reversed-phase ion-pair liquid chromatography with electrochemical detection. J Chromatogr 221: 237–247
Wagner J, Vitali P, Palfreyman MG, Zraika M, Huot S (1982) Simultaneous determination of 3,4-dihydroxyphenylalanine, 5-hydroxytryptophan, dopamine, 4-hydroxy-3methoxyphenylalanine, norepinephrine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, serotonin, and 5hydroxyindoleacetic acid in rat cerebrospinal fluid and brain by high-performance liquid chromatography with electrochemical detection. J Neurochem 38: 1241–1254
Zahniser NR, Penis J, Dwoskin LP (1986) Modulation of neurotransmitter release: an assay for receptor function. In: Chemical and functional assay of receptor binding. Soc Neurosci, Short Course 1, Syllabus, Washington, DC, pp 73–81
Cho AK, Haslett WL, Jenden DJ (1962) The peripheral actions of oxotremorine, a metabolite of tremorine. J Pharmacol Exp Ther 138: 249–257
Bebbington A, Brimblecombe RW, Shakeshaft D (1966) The central and peripheral activity of acetylenic amines related to oxotremorine. Br J Pharmacol 26: 56–57
Aronstam RS, Abood LG, Hoss W (1978) Influence of sulfhydryl reagents and heavy metals on the functional state of the muscarinic acetylcholine receptor in rat brain. Mol Pharmacol 14: 575–586
Birdsall NJM, Burgen ASV, Hulme EC (1978) The binding of agonists to brain muscarinic receptors. Mol Pharmacol 14: 723–736
Hulme EC, Birdsall NJM, Burger ASV, Mehta P (1978) The binding of antagonists to muscarinic receptors. Mol Pharmacol 14: 737–750
Sokolovsky M, Gurwitz D, Galron R (1980) Muscarinic receptor binding in mouse brain: regulation by guanine nucleotides. Biochem Biophys Res Commun 94: 487–492
Watson M, Roeske WR, Yamamura HI (1982) [3H]Pirenzepine selectively identifies a high affinity population of muscarinic cholinergic receptors in the rat cerebral cortex. Life Sci 31: 2019–2023
Ringdahl B, Jenden DJ (1983) Minireview: Pharmacological properties of oxotremorine and its analogs. Life Sci 32: 2401–2413
Olianas MC, Onali P, Neff NH, Costa E (1983) Adenylate cyclase activity of synaptic membranes from rat striatum: inhibition by muscarinic receptor agonists. Mol Pharmacol 23: 393–398
Smith CP, Huger FP (1983) Effect of zinc on [3H]-QNB displacement by cholinergic agonists and antagonists. Biochem Pharmacol 32: 377–380
Watson M, Roeske WR, Yamamura HI (1983 a) [3H]Pirenzepine selectively identifies a high affinity population of muscarinic cholinergic receptors in the rat cerebral cortex. Life Sci 31: 2019–2023
Watson M, Yamamura HI, Roeske WR (1983 b) A unique regulatory profile and regional distribution of [3H]pirenzepine in the rat provide evidence for distinct M, and MZ muscarinic receptor subtypes. Life Sci 32: 3001–3011
Brown JH, Brown SL (1984) Agonists differentiate muscarinic receptors that inhibit cyclic AMP formation from those that stimulate phosphoinositide metabolism. J Biol Chem 259: 3777–3781
Fisher SK, Figueirdo JC, Bartus R.J (1984) Differential stimulation of inositol phospholipid turnover in brain by analogs of oxotremorine. J Neurochem 43: 1171–1179
Marks MJ, O’Connor MF, Artman LD, Burch JB, Collins AC (1984) Chronic scopolamine treatment and brain cholinergic function. Pharmacol Biochem Behav 20: 771–777
Luthin GR, Wolfe BB (1984) Comparison of [3H]pirenzepine and [3H]quinuclidinylbenzilate binding to muscarinic cholinergic receptors in rat brain. J Pharmacol Exp Ther 228: 648–655
Nonaka R, Moroji T (1984) Quantitative autoradiography of muscarinic cholinergic receptors in the rat brain. Brain Res 296: 295–303
Ehlert FJ (1985) The relationship between muscarinic receptor occupancy and adenylate cyclase inhibitor in the rabbit myocardium. Mol Pharmacol 28: 410–421
El-Fakahani EE, Ramkumar V, Lai WS (1986) Multiple binding affinities of N-methylscopolamine to brain muscarinic acetylcholine receptors: differentiation from M, and MZ subtypes. J Pharmacol Exp Ther 238: 554–563
Aronstam RS, Narayanan TK (1988) Temperature effect on the detection of muscarinic receptor-G protein interactions in ligand binding assays. Biochem Pharmacol 37: 1045–1049
McKinney M, Coyle JT (1991) The potential for muscarinic receptor subtype-specific pharmacotherapy for Alzheimer’s disease. Mayo Clinic Proc 66: 1225–1237
Narahashi T (1992) Overview of toxins and drugs as tools to study excitable membrane ion channels: II. Transmitter activated channels. Meth Enzymol 207: 643–658
Berridge MJ (1987) Inositol trisphosphate and diacylglycerol: two interacting second messengers. Ann Rev Biochem 56: 159–193
Berridge MJ, Irvine RF (1984) Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 312: 315–321
Cockcroft S, Gomperts BD (1985) Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase. Nature 313: 534–536
Conklin BR, Brann MR, Ma AL, Buckley NJ, Bonner TI, Axelrod J (1988) Stimulation of arachidonic acid release in transfected cells expressing cloned muscarinic receptors. Soc Neurosci Abst 14: 600
Fisher SK, Agranoff BW (1987) Receptor activation and inositol lipid hydrolysis in neural tissues. J Neurochem 48: 999–1017
Fisher SK, Bartus RT (1985) Regional differences in the coupling of muscarinic receptors to inositol phospholipid hydrolysis in guinea pig brain. J. Neurochem. 45: 1085 1095
Fisher SK, Domask LM, Roland RM (1989) Muscarinic receptor regulation of cytoplasmic Ca“ concentrations in human SK-N-SH neuroblastoma cells: Ca’ requirements for phospholipase C activation. Mol Pharmacol 35: 195–204
Fisher SK, Figueiredo JC, Bartus RT (1984) Differential stimulation of inositol phospholipid turnover in brain by analogs of oxotremorine. J Neurochem 43: 1171–1179
Fisher SK, Klinger PD, Agranoff BW (1983) Muscarinic agonist binding and phospholipid turnover in brain. J Biol Chem 258: 7358–7363
Gusovsky F, Daly JW (1988) Formation of inositol phosphates in synaptoneurosomes of guinea pig brain: stimulatory effects of receptor agonists, sodium channel agents and sodium and calcium ionophores. Neuropharmacol 27: 95–105
Gusovsky F, Hollingsworth EB, Daly JW (1986) Regulation of phosphatidylinositol turnover in brain synaptoneurosomes: Stimulatory effects of agents that enhance influx of sodium ions. Proc Natl Acad Sci USA 83: 3003–3007
Gusovsky F, McNeal EZ, Daly JW (1987) Stimulation of phosphoinositide breakdown in brain synaptoneurosomes by agents that activate sodium influx: antagonism by tetrodotoxin, saxitoxin, and cadmium. Mol Pharmacol 32: 479–487
Heller Brown J, Brown SL (1984) Agonists differentiate muscarinic receptors that inhibit cyclic AMP formation from those that stimulate phosphoinositide metabolism. J Biol Chem 259: 3777–3788
Heller Brown J, Goldstein D, Masters SB (1985) The putative M1 muscarinic receptor does not regulate phosphoinositide hydrolysis. Mol Pharmacol 27: 525–531
Hirasawa K (1985) Phospatidylinositol turnover in receptor mechanisms and signal tranduction. Ann Rev Pharmacol Toxicol 25: 147–170
Hirasawa K, Nishizuka Y (1985) Phosphatidylinositol turnover in receptor mechanism and signal transduction. Ann Rev Pharmacol Toxicol 25: 147–170
Hokin LE and Hokin MR (1955) Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices. Biochem Biophys Acta 18: 102–110
McKinney M (1993) Muscarinic receptor subtype-specific coupling to second messengers in neuronal systems. In; Cuello AC (ed) Progress in Brain Research, Vol 98, Chapter 40, pp 333–340
Nahorski SR, Kendall DA, Batty 1 (1986) Receptors and phosphoinositide metabolism in the central nervous system. Biochem Pharmacol 35: 2447–2453
Shapiro RA, Scherer NM, Habecker BA, Subers EM, Nathanson NM (1988) Isolation, sequence and functional expression of the mouse M1 muscarinic acetylcholine receptor gene. J Biol Chem 263: 18397–18403
Alkondon M, Albuquerque EX (1993) Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes. J Pharmacol Exp Ther 265: 1455–1473
Araujo DM, Lapchak PA, Collier B, Quirion R (1988) Characterization of N-[3H]methylcarbamylcholine on acetylcholine release in rat brain J. Neurochem 51: 292–299
Araujo DM, Lapchat PA, Robitaille Y, Gauthier S, Quirion R (1988) Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer’s disease. J Neurochem 50: 1914–1923
Balfour DJK (1982) The effects of nicotine on brain neurotransmitter systems. Pharmacol Ther 16: 269–282
Clarke PBS (1987) Nicotine and smoking: A perspective from animal studies. Psychopharmacology 92: 135–143
Connolly J, Boulter J, Heinemann SF (1992) a4–32 and other nicotinic acetylcholine receptor subtypes as targets of psychoactive and addictive drugs. Br J Pharmacol 105:657666
Drasdo A, Caulfield M, Bertrand D, Bertrand S, Wonnacott(1992) Methyllycaconitine: a novel nicotinic antagonist. Mol Cell Neurosci 3: 237–243
Karlin A (1991) Explorations of the nicotinic acetylcholine receptor. Harvey Lect 85: 71–107
Lapchak PA, Araujo DM, Quirion R, Collier B (1989) Effect of chronic nicotine treatment on nicotinic autoreceptor function and N-[3H]methylcarbamylcholine binding sites in the rat brain. J Neurochem 52: 483–491
Luetje CW, Patrick J (1991) Both cc-and 13-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors. J Neurosci 11: 837–845
Luetje CW, Wada K, Rogers S, Abramson SN, Tsuji K, Heinemann S, Patrick J (1990) Neurotoxins distinguish between different neuronal nicotinic acetylcholine receptor subunit combinations. J Neurochem 55: 632–640
Mulle C, Vidal C, Benoit P, Changeux JP (1991) Existence of different subtypes of nicotinic acetylcholine receptors in the rat habenulo-interpeduncular system. J Neurosci 11: 2588–2597
Nordberg A, Winblad B (1986) Reduced number of [3H]nicotine and [3H]-acetylcholine binding sites in the frontal cortex of Alzheimer brains. Neurosci Lett 72: 115–119
Pabreza LA, Dhawan S, Kellar KJ (1991) [3H]Cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol 39: 9–12
Role LW (1992) Diversity in primary structure and function of neuronal nicotinic acetylcholine receptor channels. Curr Opin Neurobiol 2: 254. 262
Sargent PB (1993) The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci 16: 403–443
Shimohama S, Taniguchi T, Fujiwara M, Kameyama M (1986) Changes in nicotinic and muscarinic cholinergic receptors in Alzheimer-type dementia. J Neurochem 46: 288–293
Sunderland T, Tariot PN, Newhouse PA (1988) Differential responsivity of mood, behavior and cognition to cholinergic agents in elderly neuropsychiatric populations. Brain Res Rev 13: 371–389
Vernalllis AB, Conroy WG, Berg DK (1993) Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes. Neuron 10: 451–464
Whitehouse PJ, Martino AM, Wagster MV, Price DL, Mayeux R, Atack JR, Kellar KJ (1988) Reductions in [3H]nicotinic acetylcholine binding in Alzheimer’s disease and Parkinson’s disease: an autoradiographic study. Neurology 38: 720–723
Choi DW, Koh JY, Peters S (1988) Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J Neurosci 8: 185–195
Dichter MA (1986) The pharmacology of cortical neurons in tissue culture. In:Electrophysiological Techniques in Pharmacology, Alan R. Liss, Inc., pp 121–147
Furukawa S, Furukawa Y, Akazawa S, Satoyoshi E, Itoh K, Hayashi K (1983) A highly sensitive enzyme immunoassay for mouse ß nerve growth factor. J Neurochem 40: 734–744
Furukawa S, Furukawa Y, Satoyoshi E, Hayashi K (1986) Synthesis and secretion of nerve growth factor by mouse astroglial cells in culture. Biochem Biophys Res Commun 136: 57–63
Furukawa S, Furukawa Y, Satoyoshi E, Hayashi K (1987) Regulation of nerve growth factor synthesis/secretion by catecholamine in cultured mouse astroglial cells. Biochem Biophys Res Commun 147: 1048–1054
Graeber MB, Kreutzberg GW (1986) Astrocytes increase in glial fibrillary acidic protein during retrograde changes of facial motor neurons. J Neurocytol 15: 363–373
Hefti F (1986) Nerve growth factor promotes survival of septal cholinergic neurons after fibrial transsections. J Neurosci 6: 2155–2162
Kinoshita A, Yamada K, Hayakawa T (1991) Human recombinant superoxide dismutase protects primary cultured neurons against hypoxic injury. Pathobiol 59: 340–344
Koh JY, Choi DW (1988) Vulnerability of cultured cortical neurons to damage by excitotoxins: Differential susceptibility of neurons containing NADPH-diaphorase. J Neurosci 8: 2153–2163
Krieglstein J, Brungs H, Peruche B (1988) Cultured neurons for testing cerebroprotective drug effects in vitro. J Pharmacol Meth 20: 39–46
Kromer LF (1987) Nerve growth factor treatment after brain injury prevents neuronal death. Science 235: 214–216
Lärkfors L, Ebendal T (1987) Highly sensitive immunoassays for fi-nerve growth factor. J Immunol Meth 97: 41–47
Matsumoto T, Oshima K, Miyamoto A, Sakurai M, Goto M, Hayashi S (1990) Image analysis of CNS neurotrophic factor effects on neuronal survival and neurite outgrowth. J Neurosci Meth 31: 153–162
Oberpichler-Schwenk H, Krieglstein J (1994) Primary cultures of neurons for testing neuroprotective drug effects. J Neural Transm (Suppl) 44: 1–20
Ogura A, Miyamoto M, Kudo Y (1988) Neuronal death in vitro: parallelism between survivability of hippocampal neurons and sustained elevation of cytosolic Ca’ after exposure to glutamate receptor agonist. Exp Brain Res 73: 447458
Peruche B, Ahlemeyer B, Brungs H, Krieglstein J (1990) Cultured neurons for testing antihypoxic drug effects. J Pharmacol Meth 23: 63–77
Peruche B, Krieglstein J (1991) Neuroblastoma cells for testing neuroprotective drug effects. J Pharmacol Meth 26: 139–148
Prehn JHM, Backhauß C, Krieglstein J (1993) Transforming growth factor-ß, prevents glutamate neurotoxicity in rat neocortical cultures and protects mouse neocortex from ischemic injury in vivo. J Cerebr Blood Flow Metab 13: 521–525
Prehn JHM, Lippert K, Krieglstein J (1995) Are NMDA or AMPA/kainate receptor antagonists more efficacious in the delayed treatment of excitotoxic neuronal injury? Eur J Pharmacol 292: 179–189
Shinoda I, Furukawa Y, Furukawa S (1990) Stimulation of nerve growth factor synthesis/secretion by propentofylline in cultured mouse astroglial cells. Biochem Pharmacol 39: 1813–1816
Thoenen H, Barde YA (1980) Physiology of nerve growth factor. Physiol Rev 60: 1284–1355
White HS, Harmsworth WL, Sofia RD, Wof HH (1995) Felbamate modulates the strychnine-insensitive receptor. Epilepsy Res 20: 41–48
Williams LR, Varon S, Peterson GM, Wictorin K, Fischer W, Bjorklund A, Gage FH (1986) Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transsection. Proc Natl Acad Sci USA 83: 9231–9235
Yankner BA, Shooter EM (1982) The biology and mechanism of action of nerve growth factor. Ann Rev Biochem 51: 845–968
Yu ACH, Hertz E, Hertz L (1984) Alterations in uptake and release rates for GABA, glutamate, and glutamine during biochemical maturation of highly purified cultures of cerebral neurones, a GABAergic preparation. J Neurochem 42: 951–8960
Banati RB, Rothe G, Valet G, Kreutzberg GW (1991) Respiratory burst in brain macrophages: a flow cytometric study on cultured brain macrophages. Neuropath Appl Neurobiol 17: 223–230
Banati RB, Schubert P, Rothe G, Rudolphi K, Valet G, Kreutzberg GW (1994) Modulation of intracellular formation of reactive oxygen intermediates in peritoneal macrophages and microglial/brain macrophages by propentofylline. J Cerebr Blood Flow Metab 14: 145–149
Bellavite P (1988) The superoxide-forming enzymatic system of phagocytes. Free Rad Biol Med 4: 255–261
Frei K, Siepl C, Groscurth P, Bodmer S, Schwerdel C, Fontana A (1987) Antigen presentation and tumor cytotoxicity by interferon-y-treated microglial cells. Eur J Immunol 17: 1271–1278
Giulian D, Baker TJ (1986) Characterization of ameboid microglia isolated from developing mammalian brain. J Neurosci 6: 2163–2178
Rothe G, Oser A, Valet G (1988) Dihydrorhodamine 123: a new flow cytometric indicator for respiratory burst activity in neutrophil granulocytes. Naturwissensch 75: 354–355
Rothe G, Valet G (1994) Flow cytometric assays of oxidative burst activity in phagocytes. Meth Enzymol 233: 539–548
Netto CA, Izquierdo I (1985) On how passive is inhibitory avoidance. Behav Neural Biol 43: 327–330
Chorover SL, Schiller PH (1965) Short-term retrograde amnesia in rats. J Comp Physiol Psychol 59: 73–78
Dilts SL, Berry CA (1967) Effect of cholinergic drugs on passive avoidance in the mouse. J Pharmacol Exp Ther 158: 279–285
Dunn RW, Flanagan DM, Martin LL, Kerman LL, Woods AT, Camacho F, Wilmot CA, Cornfeldt ML, Effland RC, Wood
PL, Corbett R (1992) Stereoselective R-(+) enantiomer of HA-966 displays anxiolytic effects in rodents. Eur J Pharmacol 214: 207–214
Hudspeth WJ, McGaugh JL, Thomson CW (1964) Aversive and amnesic effects of electroconvulsive shock. J Comp Physiol Psycho] 57: 61–64
Jarvik ME, Essmann WB (1960) A simple one-trial learning situation in mice. Psychol Rep 6: 290
Kubanis P, Zornetzer SF (1981) Age-related behavioral and neurobiological changes: A review with emphasis on memory. Behav neural Biol 31: 115–172
Lien EJ (1993) Design and discovery of new drugs by stepping-up and stepping-down approaches. Progr Drug Res 40: 163–189
Zometzer SF, Thompson R, Rogers J (1982) Rapid forgetting in aged rats. Behav Neural Biol 36: 49–60
Banfi S, Cornelli U, Fonio W, Dorigotti L (1982) A screening method for substances potentially active on learning and memory. J Pharmacol Meth 8: 255–263
Fekete M, deWied D (1982) Potency and duration of action of the ACTH¢9 analog (ORG 2766) as compared to ACTH¢10 and [D-Phe’IACTH4_10 on active and passive avoidance behavior of rats. Pharmacol Biochem Behav 16: 387–392
Fine A, Dunnett SB, Björklund A, Iversen SD (1985) Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease. Proc Natl Acad Sci USA 82: 5227–5230
Fisher A, Brandeis R, Karton I, Pittel Z, Gurwitz D, Haring R, Sapir M, Levy A, Heldman E (1991) (±)-cis-2-Methylspiro(1,3-oxathiolane-5,3’)quinuclidine, an Ml selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer’s disease. J Pharmacol Exp Ther 257: 392–403
Hock FJ (1994) Involvement of nitric oxide-formation in the action of losartan (DUP 753): effects in an inhibitory avoidance model. Behav Brain Res 61: 163–167
Hock FJ, Gerhards HJ, Wiemer G, Stechl J, Rüger W, Urbach H (1989) Effects of the novel compound, Hoe 065, upon impaired learning and memory in rodents. Eur J Pharmacol 171: 79–85
Hock FJ, McGaugh JL (1985) Enhancing effects of Hoe 175 on memory in mice. Psychopharmacology 86: 114–117
Jarvik ME, Kopp R (1967) An improved one-trial learning situation in mice. Psychol Rep 21: 221–224
King RA, Glasser RL (1970) Duration of electroconvulsive shock-induced retrograde amnesia in rats. Physiol Behav 5: 335–339
Rush DK, Streit K (1992) Memory modulation with peripherally acting cholinergic drugs. Psychopharmacology 106: 375–382
Wan R, Diamant A, de Jong W, de Wied D (1990) Changes in heart rate and body temperature during passive avoidance behavior in rats. Physiol Behav 47: 493–499
Bures J, Buresova 0 (1963) Cortical spreading depression as a memory disturbing factor. J Comp Physiol Psychol 56: 268–272
Gouret C, Raynaud G (1976) Utilisation du test de la boite a deux compartiments pour la recherche de substances protégeant le rat contre l’amnésie par hypoxie: Intérèt at limites de la méthode. J Pharmacol (Paris) 7: 161–175
Kurtz KH, Pearl J (1960) The effect of prior fear experience on acquired-drive learning. J Comp Physiol Psycho] 53: 201–206
Staubli U, Huston JP (1978) Up-hill avoidance: A new passive avoidance task. Physiol Behav 21: 775–776
Brioni JD (1993) Role of GABA during the multiple consolidation of memory. Drug Dev Res 28: 3–27
Decker MW, Tran T, McGaugh JL (1990) A comparison of the effects of scopolamine and diazepam on acquisition and retention of inhibitory avoidance in mice. Psychopharmacology 100: 515–521
Fine A, Dunnett SB, Bjorklund A, Iversen SD (1985): Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer’s disease. Proc Natl Acad Sci, USA 82: 5227–5230
Hepler DJ, Wenk G, Cribbs BL, Olton DS, Coyle JT (1985) Memory impairments following basal forebrain lesions. Brain Res 346: 8–14
Kameyama T, Nabeshima T, Kozawa T (1986) Step-down-type passive avoidance-and escape-learning method. J Pharmacol Meth 16: 39–52
Tomaz C, Dickinson-Anson H, McGaugh JL (1992): Basolateral amygdala lesions block diazepam-induced anterograde amnesia in an inhibitory avoidance task. Proc Natl Acad Sci USA 89: 3615–3619
Dilts SL, Berry CA (1976) Effects of cholinergic drugs on passive avoidance in the mouse. J Pharmacol Exper Ther 158: 279–285
Drachman DA, Leavitt J (1974) Human memory and the cholinergic system. Arch Neurol 30: 113–121
Glick SD, Zimmerberg B (1972) Amnesic effects of scopolamine. Behav Biol 7: 245–254
Porsolt RD, Lenègre A, Avril I, Doumont G (1988) Antagonism by exifone, a new cognitive enhancing agent, of the amnesias induced by four benzodiazepines in mice. Psychopharmacology 95: 291–297
Schindler U, Rush DK, Fielding S (1984) Nootropic drugs: Animal models for studying effects on cognition. Drug Devel Res 4: 567–576
Yamaoto T, Yatsugi SI, Ohno M, Furuya Y, Kitajima I, Ueki S (1990) Minaprine improves impairment of working memory induced by scopolamine and cerebral ischemia in rats. Psychopharmacology 100: 316–322
Connor DJ, Langlais PJ, Thal LJ (1991) Behavioral impairment after lesions of the nucleus basalis by ibotenic acid and quisqualic acid. Brain Res 555: 84
Dunnett SB, Whishaw IQ, Jones GH, Bunch ST (1989) Behavioral, biochemical and histochemical effects of different neurotoxic amino acids injected into nucleus basalis magnocellularis of rats. Neurosci 20: 653–669
Fonnum F (1975) A rapid radiochemical method for the determination of choline acetyltransferase. J Neurochem 24: 407–409
Fuji K, Hiramatsu M, Hayashi S, Kameyama T, Nabeshima T (1993b) Effects of propentofylline, a NGF stimulator, on alterations in muscarinic cholinergic receptors induced by basal forebrain lesion in rats. Neurosci Lett 150: 99–102
Fuji K, Hiramatsu M, Kameyama T, Nabeshima T (1993a) Effects of repeated administration of propentofylline on memory impairment produced by basal forebrain lesion in rats. Eur J Pharmacol 236: 411–417
Morris RGM (1981) Spatial localization does not require the presence of local cues. Learn Motitiv 12: 239–260
Chandler MJ, DeLeo JA, Carney JM (1985) An unanesthetized-gerbil model of cerebral ischemia-induced behavioral changes. J Pharmacol Meth 14: 137–146
Gibson GE, Pulsinelli W, Blass JP, Duffy TE (1981) Brain dysfunction in mild to moderate hypoxia. Am J Med 70: 1247–1254
Levine S, Sohn D (1969) Cerebral ischemia in infant and adult gerbils. Arch Pathol 87: 315–317
Lundy EF, Solik BS, Frank RS, Lacy PS, Combs DJ, Zelenok GB, D’Alecy LG (1986) Morphometric evaluation of brain infarcts in rats and gerbils. J Pharmacol Meth 16: 201–214
Schindler U (1983) The effect of graded cerebral ischemia on brain water content and learning ability in the Mongolian gerbil. J Cerebr Blood Flow Metab 3: S335 — S336
Schindler U (1983) The effect of graded cerebral ischemia on brain water content and learning ability in the Mongolian gerbil. J Cerebr Blood Flow Metab 3: S335 — S336
Schindler U, Rush DK, Fielding S (1984) Nootropic drugs: Animal models for studying effects on cognition. Drug Devel Res 4: 567–576
Brush FR (1971) Aversive Conditioning and Learning. Academic Press, New York and London
Campbell BA, Church RM (1969) Punishment and Aversive Behavior. Appleton-Century-Crofts, New York, NY
D’Amato MR (1970) Experimental Psychology: Methodology, Psychophysics and Learning. McGraw-Hill, New York, NY, pp 381–416
Herrnstein RJ (1969) Method and theory in the study of avoidance. Psychol Rev 76: 49–69
Capaldi EJ, Capaldi ED (1972) Aversive learning situations: apparatus and procedures. In: Myers RD (ed) Methods in Psychobiology, Vol. 2, Academic Press, London and New York, NY, pp 59–81
Hock FJ, McGaugh JL (1985) Enhancing effects of Hoe 175 on memory in mice. Psychopharmacology 86: 114–117
Munn NL (1950) Handbook of Psychological Research on the Rat. Houghton Mifflin, Boston, MA
Silverman P (1978) Conditioned avoidance of aversive stimuli. In: Animal behaviour in the laboratory. Chapman and Hall, London, pp 204–219
Capaldi EJ, Capaldi ED (1972) Aversive learning situations: apparatus and procedures. In: RD. Myers (ed.), Methods in Psychobiology, Vol. 2, Academic Press, London and New York, NY, pp 59–81
Netto CA, Valente JT, Borges-Sobrinho JB, Lasevitz J, Tomaz CA (1991) Reversal of retrieval impairment caused by retroactive interference in a two-way active avoidance task in rats. Behav Neur Biol 55: 114–122
McKean DB, Pearl J (1968) Avoidance box for mice. Physiol Behav 3: 795–796
Tenen SS (1966) An automated one-way avoidance box for the rat. Psychonom Sci 6: 407–408
Gilbert RM (1969) Discrimination learning? In: Gilbert RM, Sutherland NS (eds) Animal Discrimination Learning. Academic Press, New York, NY and London, pp 455–498
Hurwitz HMB (1969) Discrimination learning under avoidance schedules. In: Gilbert RM, Sutherland NS (eds) Animal Discrimination Learning. Academic Press, New York, NY and London, pp 413–454
Siegel S (1969) Discrimination overtraining and shift behavior. In: Gilbert RM, Sutherland NS (eds) Animal Discrimination Learning. Academic Press, New York, NY and London, pp 187–213
Sutherland NS (1969) Outlines of a theory of visual pattern recognition in animals and man. In: Gilbert RM, Sutherland NS (eds) Animal Discrimination Learning. Academic Press, New York, NY and London, pp 385–411
Barnes CA (1979) Memory deficits associated with senescence: a neurophysiological and behavioral study in rat. J Comp Physiol Psycho! 93: 74–104
Lamberty Y, Gower Ai (1990) Age-related changes in spontaneous behavior and learning in NMRI mice from maturity to middle age. Physiol Behav 47: 1137–1144
Sara SJ, Devauges V (1989) Idazoxan, an a-2 antagonist, facilitates memory retrieval in the rat. Behav Neural Biol 51: 401–411
Siegel S (1969) Discrimination overtraining and shift behavior. In: Gilbert RM, Sutherland NS (eds.) Animal Discrimination Learning, Academic Press, New York, NY, pp 187–213
Buresova O, Bures J, Oitzl M, Zahalka A (1985): Radial maze in the water tank: an aversively motivated spatial working memory task. Physiol Behav 34: 1003–1005
Kesner R (1980): An attribute analysis of memory: the role of the hippocampus. Physiol Psychol 8: 189–197
Kesner R (1986): Neurobiological views of memory, In: Martinez J, Kesner R (eds): Learning and Memory, Academic Press, Inc.: Orlando, pp 399–438
Levin ED (1988): Psychopharmacological effects in the radial-arm maze. Neurosci Biobehav Rev 12: 169–175
Olton D, Walker J, Gage F (1978): Hippocampal connections and spatial discrimination. Brain Res 139: 295–308
Olton DS (1983) Memory functions and the hippocampus. In: Seifert W (ed) Neurobiology of the Hippocampus. Academic Press, London, New York, pp 335–373
Olton DS, Becker J, Handelman G (1979): Hippocampus, space and memory. The Behavioral and Brain Sciences 2: 313–365
Olton DS, Samuelson RJ (1976): Remembrance of places passed: spatial memory in rats. J Exp Psychol An Behav Proc 2: 97–116
Grilsser OJ, Klinke R. (eds): Pattern Recognition in Biological and Technical Systems. Springer Verlag, Berlin ( 1971 ) Munn NL Handbook of Psychological Research on the Rat. Houghton Mifflin, Boston, MA (1950)
Sutherland NS (1969) Outlines of a theory of visual pattern recognition in animals and man. In: Gilbert RM, Sutherland NS (eds.). Animal Discrimination Learning. Academic Press, New York, NY, pp 385–411
Thompson R (1969) Localization of the `visual memory sys-tem’ in the white rat. J Comp Physiol Psychol 69: 1–29
Thompson R, Huestis PW, Crinella FM, Yu J (1987) Further lesion studies on the neuroanatomy of mental retardation in the white rat. Neurosci Biobehav Rev 11: 415–440
Brandeis R, Dachir S, Sapir M, Levy A, Fisher A (1990) Reversal of age-related cognitive impairments by an M1 cholinergic agent, AF102B. Pharmacol Biochem Behav 36: 89–95
Brioni JD, Arolfo MP, Jerusalinski D, Medina JH, Izquierdo I (1991): The effect of flumazenil on acquisition, retention and retrieval of spatial information. Behav Neural Biol 56: 329–335
Brioni JD, Decker MW, Gamboa LP, Izquierdo I, McGaugh JL (1990): Muscimol injections in the medial septum impair spatial learning. Brain Res 522: 227–234
Buresova O, Krekule I, Zahalka A, Bures J (1985): On-demand platform improves accuracy of the Morris water maze. J Neurosci Meth 15: 63–72
Decker MW, Majchrzak MJ, Anderson DJ (1992): Effects of nicotine on spatial memory deficits in rats with spatial lesions. Brain Res 572: 281–285
Gallagher M, Burwell R, Burchinal M (1993): Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze. Behav Neurosci 107: 618–626
McNamara R, Skelton R (1993): The neuropharmacological and neurochemical basis of place learning in the Morris water maze. Brain Res Rev 18: 33–49
Morris R (1984): Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Meth 11: 4760
Morris R, Anderson E, Lynch G, Baudry M (1986): Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist. Nature 319: 774–776
Morris RGM (1981) Spatial localization does not require the presence of local cues. Learn Motitiv 12: 239–260
Morris RGM (1989): Synaptic plasticity and learning: Selective impairment in rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. J Neurosci 9: 3040–3057
Rapp PR, Rosenberg RA, Gallagher M (1987): An evaluation of spatial information processing in aged rats. Behay. Neurosci 101: 3–12
Eichenbaum H, Otto T, Cohen NJ (1992): The hippocampuswhat does it do? Behay. Neural Biol 57: 2–36
Lynch G, Stäubli U (1991): Possible contributions of longterm potentiation to the encoding and organization of memory. Brain Res Rev 16: 204–206
Nigrosh BJ, Slotnik BM, Nevin JA (1957): Olfactory discrimination, reversal learning and stimulus control in rats. J Comp Physiol Psychol 89: 285–194
Otto T, Schottler F, Stäubli U, Eichenbaum H, Lynch G (1991): Hippocampus and olfactory discrimination learning: effects of entorhinal cortex lesions on olfactory learning and memory in a successive-cue go-no-go task. Behav Neurosci 105: 111–119
Ravel N, Vigouroux M, Elaagouby A, Gervais R (1992): Scopolamine impairs delayed matching in an olfactory task in rats. Psychopharmacology 109: 439–443
Roman F, Han D, Baudry M (1989): Effects of two ACTH analogs on successive odor discrimination learning in rats. Peptides 10: 303–307
Roman FS, Simonetto I, Soumireu-Mourat B (1993): Learning and memory of odor-reward association: selective impairment following horizontal diagonal band lesions. Behav Neurosci 107: 72–81
Stäubli U, Ivy G, Lynch G (1984): Hippocampal denervation causes rapid forgetting of olfactory information in rats. Proc Natl Acad Sci, USA 81: 5885–5887
Bantus RT (1979) Physostigmine and recent memory: Effects in young and aged non-human primates. Science 206: 1087–1089
Bartus RT(1979) Effects of aging on visual memory, sensory processing and discrimination learning in the non-human primate. In: Ordy JM, Brizzee K (eds.) Aging. Vol. 10. Raven Press, New York, NY, pp 85–114
Bartus RT, Dean RL (1981) Age-related memory loss and drug therapy: Possible directions based on animal models. In: Enna SJ, Samorajski T, Beer B (eds.) Aging Vol. 17. Raven Press New York, NY, pp 209–223
Dean RL, Loullis C, Bartus RT (1983) Drug effects in an animal model of memory deficits in the aged: implications for future clinical trials. In: Walker RF, Cooper RL (eds) Experimental and Clinical Interventions in Aging. Marcel Dekker, New York, NY, pp 279–303
Struble RG, Cork LC, Whitehouse PJ, Price DL (1982) Cholinergic innervation in neuritic plaques. Science 216: 413–414
Wisniewski HM, Ghetti T, Terry RD (1973) Neuritic (senile) plaques and filamentous changes in aged Rhesus monkeys. J Neuropathol Exp Neurol 32: 566–584
Alger BE, Dhanjal SS, Dingledine R, Garthwaite J, Henderson G, King GL, Lipton P, North A, Schwartzkroin PA, Sears TA, Segal M, Whittingham TS, Williams J (1984) Brain slice methods. In: R. Dingledine (ed.). Brain Slices, Plenum Press. New York, NY pp 381–437
Bliss TVP, Lemo T (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 232: 331–356
Dingledine RY, Dodd Y, Kelly JS (1980) The in vitro brain slice as a useful neurophysiological preparation for intracellular recording. J Neurosci Methods 2: 323–362
Kettenmann H, Grantyn R (eds.): Practical electrophysiological methods. Wiley-Liss, New York, NY (1992)
Landfield PW, Deadwyler SA (eds) (1988): Long-term Potentiation: From Biophysics to Behavior. Alan R. Liss, Inc., New York, NY
Mcllwain H, Rodnight R (1962) Preparing neural tissues for metabolic study in vitro. In: Mcllwain H, Rodnight R (eds.) Practical neurochemistry. Churchill Ltd. London, pp 109133
Milner B (1972) Disorders of learning and memory after tem- poral lobe lesions in man. Clin Neurosurg 19: 421–446
Misgeld U (1992) Hippocampal Slices. In: Kettenmann H, Grantyn R (eds.): Practical electrophysiological methods. Wiley-Liss, New York, NY, pp 41–44
Scoville WB, Milner B (1957) Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 20: 11–21
Tanak Y, Sakurai M, Goto M, Hayashi S (1990) Effect of xanthine derivatives on hippocampal long-term potentiation Teyler TJ (1980) Brain slice preparations: Hippocampus. Brain Res Bull 5: 391–403
Barclay LL, Gibson GE, Blass PJ (1981) The string test: An early behavioral change in thiamine deficiency. Pharmacol Biochem Behav 14: 153–157
Gibson GE, Blass JP (1976) Impaired synthesis of acetylcholine in brain accompanying mild hypoxia and hypoglycemia. J Neurochem 27: 37–42
Gibson GE, Pelmas CJ, Peterson C (1983) Cholinergic drugs and 4-aminopyridine alter hypoxic-induced behavioral deficits. Pharmacol Biochem Behav 18: 909–916
Gibson GE, Pulsinelli W, Blass JP, Duffy TE (1981) Brain dysfunction in mild to moderate hypoxia. Am J Med. 70: 1247–1254
Gibson GE, Shimada M, Blass JP (1978) Alterations in acetylcholine synthesis and cyclic nucleotides in mild cerebral hypoxia. J Neurochem 31: 757–760
Hock FJ (1993) Effects of cromakalim on sodium nitrite intoxication. In: Elsner N, Heisenberg M (eds.) Gene, Brain and Behaviour. Proceedings of the 21st Göttingen Neurobiology Conference. Georg Thieme Verlag, Stuttgart, 681
Peterson C, Gibson GE (1982) 3,4-Diaminopyridine alters acetylcholine metabolism and behavior during hypoxia. J Pharmacol Exp Ther 222: 576–582
Schindler U, Rush DK, Fielding S (1984) Nootropic drugs: Animal models for studying effects on cognition. Drug Develop Res 4: 567–576
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Vogel, H.G., Vogel, W.H. (1997). Drug effects on learning and memory. In: Vogel, H.G., Vogel, W.H. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03333-3_6
Download citation
DOI: https://doi.org/10.1007/978-3-662-03333-3_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-03335-7
Online ISBN: 978-3-662-03333-3
eBook Packages: Springer Book Archive