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Sperm-Zona Pellucida Interaction: A Model for Zona Receptor Kinase-Mediated Signaling

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Signal Transduction in Testicular Cells

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 2/1996))

Abstract

Successful mammalian fertilization requires the precise recognition and interaction of specific molecules on the sperm with complementary molecules of the egg. Over the last decade, the identification of many of the proteins involved in these events has significantly advanced our understanding of the molecular basis of gamete interaction. In addition to permitting focused attention on each of the individual gamete components identified, this analysis has re-enforced the concept that the intercellular interactions between sperm and eggs that lead to fertilization are similar to many aspects of somatic cell interactions.

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References

  • Almeida EA, Huovila AP, Sutherland AE, Stephens LE, Calarco PG, Shaw LM, Mercurio AM, Sonnenberg A, Primakoff P, Myles DG (1995) Mouse egg integrin α6β1 functions as a sperm receptor. Cell 81:1095–1104.

    Article  PubMed  CAS  Google Scholar 

  • Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC (1989) PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 57:167–175.

    Article  PubMed  CAS  Google Scholar 

  • Bennett MK, Scheller RH (1993) The molecular machinery for secretion is conserved from yeast to neurons. Proc Natl Acad Sci USA 90:2559–2563.

    Article  PubMed  CAS  Google Scholar 

  • Berridge MJ, Dawson M, Downes CP, Heslop JP, Irvine RF (1983) Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem J 212:473–482.

    PubMed  CAS  Google Scholar 

  • Blobel CP, Wolfsberg TG, Turck CW, Myles DG, Primakoff P, White JM (1992) A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion. Nature 356:248–252.

    Article  PubMed  CAS  Google Scholar 

  • Bookbinder LH, Cheng A, Bleil JD (1995) Tissue-and species-specific expression of sp56, a mouse sperm fertilization protein. Science 269:86–89.

    Article  PubMed  CAS  Google Scholar 

  • Burks DJ, Carballada R, Moore HDM, Saling PM (1995a) Interaction of a tyrosine kinase from human sperm with the zona pellucida at fertilization. Science 269:83–86.

    Article  PubMed  CAS  Google Scholar 

  • Burks DJ, McLeskey SB, Morales P, Saling PM (1995b) Activation of human sperm ZRK using recombinant human ZP3 (submitted).

    Google Scholar 

  • Burks DJ, Tomes CN, Saling PM (1995c) PI 3-Kinase couples to ZRK and regulates acrosomal exocytosis in human sperm (submitted).

    Google Scholar 

  • Cardullo RA, Wolf DE (1995) Distribution and dynamics of mouse sperm surface galactosyltransferase: implications for mammalian fertilization. Biochemistry 34:10027–10035.

    Article  PubMed  CAS  Google Scholar 

  • Cheng A, Le T, Palacios M, Bookbinder LH, Wassarman PM, Suzuki F, Bleil JD (1994) Sperm-egg recognition in the mouse: characterization of sp56, a sperm protein having specific affinity for ZP3. J Cell Biol 125:867–878.

    Article  PubMed  CAS  Google Scholar 

  • Cunningham SA, Waxham MN, Arrate PM, Brock TA (1995) Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase — mapping of a novel site involved in binding. J Biol Chem 270:20254–20257.

    Article  PubMed  CAS  Google Scholar 

  • Epifano O, Dean J (1994) Biology and structure of the zona pellucida: a target for immunocontraception. Reprod Fertil Dev 6:319–330.

    Article  PubMed  CAS  Google Scholar 

  • Fry MJ, Waterfield MD (1993) Structure and function of phosphatidylinositol 3-kinase: a potential second messenger system involved in growth control. Philos Trans R Soc Lond 340:337–344.

    Article  CAS  Google Scholar 

  • Gmachl M, Sagan S, Ketter S, Kreil G (1993) The human sperm protein PH-20 has hyaluronidase activity. FEBS Lett 336:545–548.

    Article  PubMed  CAS  Google Scholar 

  • Gong XH, Dubois DH, Miller DJ, Shur BD (1995) Activation of a G protein complex by aggregation of β-1,4-galactosyltransferase on the surface of sperm. Science 269:1718–1721.

    Article  PubMed  CAS  Google Scholar 

  • Leyton L, Saling P (1989a) 95 kD sperm proteins bind ZP3 and serve as tyrosine kinase substrates in response to zona binding. Cell 57:1123–1130.

    Article  PubMed  CAS  Google Scholar 

  • Leyton L, Saling P (1989b) Evidence that aggregation of mouse sperm receptors by ZP3 triggers the acrosome reaction. J Cell Biol 108:2163–2168.

    Article  PubMed  CAS  Google Scholar 

  • Leyton L, LeGuen P, Bunch D, Saling PM (1992) Regulation of mouse gamete interaction by a sperm tyrosine kinase. Proc Natl Acad Sci USA 89:11692–11695.

    Article  PubMed  CAS  Google Scholar 

  • Li W, Nishimura R, Kashishian A, Batzer AG, Kim WJH, Cooper JA, Schlessinger J (1994) A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol Cell Biol 14:509–517.

    Article  PubMed  CAS  Google Scholar 

  • Lin Y, Mahan K, Lathrop WF, Myles DG, Primakoff P (1994) A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg. J Cell Biol 125:1157–1163.

    Article  PubMed  CAS  Google Scholar 

  • Lo Leggio L, Williams RM, Jones R (1994) Some effects of zona pellucida glycoproteins and sulfated polymers on the autoactivation of boar sperm proacrosin and activity of β-acrosin. J Reprod Fertil 100:177–185.

    Article  Google Scholar 

  • Miller DJ, Macek MB, Shur BD (1992) Complementarity between sperm surface β-1,4-galactosyltransferase and egg-coat ZP3 mediates sperm-egg binding. Nature 357:589–593.

    Article  PubMed  CAS  Google Scholar 

  • Moore HDM, Hartman TD, Bye AP, Lutjen P, De Witt M, Trounson AO (1987) Monoclonal antibody against a sperm antigen Mr 95,000 inhibits attachment of human spermatozoa to the zona pellucida. J Reprod Immunol 11:157–166.

    Article  PubMed  CAS  Google Scholar 

  • Myles DG, Primakoff P (1991) Sperm proteins that serve as receptors for the zona pellucida and their post-testicular modification. Ann N Y Acad Sci 637:486–493.

    Article  PubMed  CAS  Google Scholar 

  • Ning X, Ward CR, Kopf GS (1995) Activation of a Gi protein in digitonin/cholate-solubilized membrane preparations of mouse sperm by the zona pellucida, an egg-specific extracellular matrix. Mol Reprod Dev 40:355–363.

    Article  PubMed  CAS  Google Scholar 

  • Nishibe S, Wahl MI, Hernandez-Sotomayor SM, Tonks NK, Rhee SG, Carpenter G (1990) Increase of the catalytic activity of phospholipase C-γ1 by tyrosine phosphorylation. Science 250:1253–1256.

    Article  PubMed  CAS  Google Scholar 

  • Rhee SG, Choi KD (1992a) Regulation of inositol phospholipid-specific phospholipase C isozymes. J Biol Chem 267:12393–12396.

    PubMed  CAS  Google Scholar 

  • Rhee SG, Choi KD (1992b) Multiple forms of phospholipase C isozymes and their activation mechanisms. Adv Sec Messenger Phosphoprot Res 26:35–61.

    CAS  Google Scholar 

  • Rhee SG, Ryu SH, Lee KY, Cho KS (1991) Assays of phosphoinositide-specific phospholipase C and purification of isozymes from bovine brains. Methods Enzymol 197:502–511.

    Article  PubMed  CAS  Google Scholar 

  • Saling PM, Burks DJ, Carballada MR, Dowds CA, Leyton L, McLeskey SB, Robinson AG, Tomes CN (1995) Sperm interaction with the zona pellucida: the role of ZRK. In: Fenichel P, Parinaud J (eds) The human sperm acrosome reaction. Libbey Eurotext, Montrouge, France, pp 85–104.

    Google Scholar 

  • Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, Ren R, Baltimore D, Ratnofsky S, Feldman RA, Cantley LC (1994) Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol 14:2777–2785.

    Article  PubMed  CAS  Google Scholar 

  • Stephens LR, Jackson TR, Hawkins PT (1993) Agonist-stimulated synthesis of phosphatidylinositol(3,4, 5)-trisphosphate: a new intracellular signalling system. Biochim Biophys Acta Mol Cell Res 1179:27–75.

    Article  CAS  Google Scholar 

  • Suh PG, Ryu SH, Choi WC, Lee KY, Rhee SG (1988) Monoclonal antibodies to three phospholipase C isozymes from bovine brain. J Biol Chem 263:14497–14504.

    PubMed  CAS  Google Scholar 

  • Tomes CN, McMaster C, Saling PM (1995) Activation of mouse PIP2-PLC by zona pellucida is modulated by tyrosine phosphorylation. Mol Reprod Dev (in press).

    Google Scholar 

  • Topfer-Petersen E, Cechova D (1990) Zona pellucida induces conversion of proacrosin to acrosin. Int J Androl 13:190–196.

    Article  PubMed  CAS  Google Scholar 

  • Van der Geer P, Hunter T, Lindberg RA (1994) Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol 10:251–337.

    Article  PubMed  Google Scholar 

  • Varticovski L, Harrison-Findik D, Keeler ML, Susa M (1994) Role of PI 3-ki-nase in mitogenesis. Biochim Biophys Acta Mol Basis Dis 1226:1–11.

    Article  CAS  Google Scholar 

  • Ward CR, Kopf GS (1993) Molecular events mediating sperm activation. Dev Biol 158:9–34.

    Article  PubMed  CAS  Google Scholar 

  • Wassarman PM (1994) Gamete interactions during mammalian fertilization. Theriogenology 41:31–44.

    Article  Google Scholar 

  • Wassarman PM (1995) Mammalian fertilization — egg and sperm (glycoproteins. Am J Reprod Immunol 33:253–258.

    PubMed  CAS  Google Scholar 

  • Williams RM, Jones R (1993) Specificity of binding of zona pellucida glycoproteins to sperm proacrosin and related proteins. J Exp Zool 266:65–73.

    Article  PubMed  CAS  Google Scholar 

  • Wolfsberg TG, Primakoff P, Myles DG, White JM (1995) ADAM, a novel family of membrane proteins containing a disintegrin and metalloprotease domain — multipotential functions in cell-cell and cell-matrix interactions. J Cell Biol 131:275–278.

    Article  PubMed  CAS  Google Scholar 

  • Yagamihiromasa T, Sato T, Kurisaki T, Kamijo K, Nabeshima Y, Fujisawasehara A (1995) A metalloprotease-disintegrin participating in myoblast fusion. Nature 377:652–656.

    Article  CAS  Google Scholar 

  • Yanagimachi R (1994) Mammalian fertilization. In: Knobil E, Neill JD (eds) The physiology of reproduction. Raven, New York, pp 189–317.

    Google Scholar 

  • Yano H, Nakanishi S, Kimura K, Hanai N, Saitoh Y, Fukui Y, Nonomura Y, Matsuda Y (1993) Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem 268:25846–25856.

    PubMed  CAS  Google Scholar 

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© 1996 Springer-Verlag Berlin Heidelberg

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Saling, P.M., Burks, D.J., Tomes, C.N. (1996). Sperm-Zona Pellucida Interaction: A Model for Zona Receptor Kinase-Mediated Signaling. In: Hansson, V., Levy, F.O., Taskén, K. (eds) Signal Transduction in Testicular Cells. Ernst Schering Research Foundation Workshop, vol 2/1996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03230-5_12

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  • DOI: https://doi.org/10.1007/978-3-662-03230-5_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-03232-9

  • Online ISBN: 978-3-662-03230-5

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