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Apoptosis in Hormone-Dependent Cancers pp 35–55Cite as

Apoptosis in Experimental Prostate Cancer

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Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 14))

Abstract

Metastatic prostate cancer is a disease with a high incidence and mortality rate despite advances in early diagnosis and therapeutic intervention (Carter et al. 1990; Schröder 1991). Androgen ablation therapy aiming at reducing tumor burden by inhibition of proliferative activity and inducing programmed cell death (apoptosis) in the tumor tissue is still the current frontline therapy for (advanced) prostate carcinoma (Walsh 1975; Menon and Walsh 1979; Szende et al. 1993). After an initial response, however, tumor relapse occurs due to the growth of androgen-independent prostate cancer cells. This relapse develops even if complete androgen blockade is used, and as a consequence androgen ablation is rarely curative.

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Authors
  1. G. J. van Steenbrugge
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  2. W. M. van Weerden
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  3. M. H. A. Oomen
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  4. C. M. A. de Ridder
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  5. T. H. van der Kwast
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  6. F. H. Schröder
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Editor information

Editors and Affiliations

  1. W. Alton Jones Cell Science Center, 10 Old Barn Road, 12946, Lake Placid, NY, USA

    Martin Tenniswood

  2. Research Laboratories, Schering AG, Müllerstraße 170-178, 13342, Berlin, Germany

    Horst Michna

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© 1995 Springer-Verlag Berlin Heidelberg

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van Steenbrugge, G.J., van Weerden, W.M., Oomen, M.H.A., de Ridder, C.M.A., van der Kwast, T.H., Schröder, F.H. (1995). Apoptosis in Experimental Prostate Cancer. In: Tenniswood, M., Michna, H. (eds) Apoptosis in Hormone-Dependent Cancers. Ernst Schering Research Foundation Workshop, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03122-3_2

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  • DOI: https://doi.org/10.1007/978-3-662-03122-3_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-03124-7

  • Online ISBN: 978-3-662-03122-3

  • eBook Packages: Springer Book Archive

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