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Radiation Therapy Physics pp 365–384Cite as

Dosimetry of Radiolabeled Antibodies

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Even before the advent of monoclonal antibodies, clinicians and scientists had been intrigued by the possibility of selectively targeting tumors and metastatic disease with a variety of agents including hormones, transmitters, drugs, metabolites, and polyclonal antibodies (Wagner 1968). Naturally, if it was found that any of these agents were not sufficiently cytotoxic to the tumor, a radionuclide label was added to promote selective tumor lethality and “action at a distance” tumor cell kill. This addition of the radionuclide to the biologically targeted therapy also made it possible to externally monitor the time-dependent distribution of the agent in animals and humans.

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Authors and Affiliations

  1. Department of Radiation Oncology, George Washington University Medical Center, 901 Twenty Third St. NW, Washington, DC, 20037, USA

    Barry W. Wessels PhD

  2. Department of Radiation Oncology, University of Alabama-Birmingham, 619 S. 19th Street, Birmingham, AL, 35233, USA

    Donald J. Buchsbaum PhD

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  1. Barry W. Wessels PhD
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Editors and Affiliations

  1. Department of Radiation Medicine, Massachusetts General Hospital, Cox Bldg., 3rd Floor, Boston, MA, 02114, USA

    Alfred R. Smith PhD (Radiation Biophysicist) (Radiation Biophysicist)

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Wessels, B.W., Buchsbaum, D.J. (1995). Dosimetry of Radiolabeled Antibodies. In: Smith, A.R. (eds) Radiation Therapy Physics. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03107-0_15

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  • DOI: https://doi.org/10.1007/978-3-662-03107-0_15

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