Treatment Optimization Using Physical and Radiobiological Objective Functions

  • Anders Brahme
Part of the Medical Radiology book series (MEDRAD)


Radiation therapy is a truly multidisciplinary field where the developments have taken place gradually and almost coherently in many different areas. This is fortunate because a chain is only as strong as its weakest link, and significant developments in one single area are not always sufficient for general improvements of the overall performance. The development of radiation therapy planning during the last decade has been enormous. We have witnessed an unprecedented improvement in three-dimensional (3D) diagnostic imaging through the advent of computed tomography (CT ), magnetic resonance imaging, single-photon emission tomography, positron emission tomography, and ultrasound techniques. Simultaneously, we have seen a considerable improvement of dose-planning systems that now are capable of making use of this new diagnostic information and in some cases perform true 3D dose planning to improve the accuracy in the delivered dose distributions.


Target Volume Dose Distribution Dose Delivery Pencil Beam Irradiation Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Anders Brahme
    • 1
    • 2
  1. 1.Department of Medical Radiation PhysicsThe Karolinska InstituteStockholmSweden
  2. 2.Department of Medical Radiation PhysicsUniversity of StockholmStockholmSweden

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