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Abstract

The nucleus of the cell contains the structural information for all proteins present in the cell, and is responsible directly or indirectly for the synthesis of all molecules in the cell. The information is coded in deoxyribonucleic acid (DNA) by the sequence of four nitrogenous bases: the purines adenine and guanine (A and G), and the pyrimidines cytosine and thymine (C and T). The information is carried in the form of a three letter code, the letters being A, G, C and T. Different arrangements of three consecutive bases code for different amino acids in the peptides to be synthesized. Such coding triplets are called codons. The segment of DNA that codes for one peptide chain is called a gene. Peptides are strings of amino acids that form the building blocks of enzymes and other proteins. There are 20 naturally occurring amino acids.

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References

  • Burn J (1994) Relevance of the human genome project to inherited metabolic disease. J Inherited Metab Dis 17: 421429

    Google Scholar 

  • Cattanach BM, Jones J (1994) Genetic imprinting in the mouse: implications for gene regulation. J Inherited Metab Dis 17: 403–420

    Article  PubMed  CAS  Google Scholar 

  • Craig IW (1994) Organization of the human genome. J Inherited Metab Dis 17: 391–402

    Article  PubMed  CAS  Google Scholar 

  • Edlin G (1990) Human genetics. Jones and Bartlett, Boston Giannelli F (1986) DNA maintenance and its relation to human pathology. J Cell Sci 4 Suppl: 383–416

    Google Scholar 

  • Lambert WC (1987) Genetic diseases associated with DNA and chromosomal instability. Dermatol Clin 5: 85–108

    PubMed  CAS  Google Scholar 

  • Martin JB (1993) Molecular genetics in neurology. Ann Neurol 34: 757–773

    Article  PubMed  CAS  Google Scholar 

  • Mazzarello P, Poloni M, Spadari S, Focher F (1992) DNA repair mechanisms in neurological diseases: facts and hypotheses. J Neurol Sci 112: 4–14

    Article  PubMed  CAS  Google Scholar 

  • Rosenthal N (1994) DNA and the genetic code. N Engl J Med 331: 39–41

    Article  PubMed  CAS  Google Scholar 

  • Rosenthal N (1994) Stalking the gene–DNA libraries. N Engl J Med 331: 599–600

    Article  PubMed  CAS  Google Scholar 

  • Rosenthal N (1994) Regulation of gene expression. N Engl J Med 331: 931–933

    Article  PubMed  CAS  Google Scholar 

  • Tager JM, Aerts JMFG, Van den Bogert C, Wanders RJA (1994) Signals on proteins, intracellular targeting and inborn errors of organellar metabolism. J Inherited Metab Dis 17: 459–469

    Article  PubMed  CAS  Google Scholar 

  • Weatherall DJ (1991) The new genetics and clinical practice. Oxford University Press, Oxford

    Google Scholar 

Download references

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© 1995 Springer-Verlag Berlin Heidelberg

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van der Knaap, M.S., Valk, J. (1995). Nucleus, DNA, and DNA Repair. In: Magnetic Resonance of Myelin, Myelination, and Myelin Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03078-3_26

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  • DOI: https://doi.org/10.1007/978-3-662-03078-3_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-03080-6

  • Online ISBN: 978-3-662-03078-3

  • eBook Packages: Springer Book Archive

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