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Magnetic Resonance of Myelin, Myelination, and Myelin Disorders pp 129–139Cite as

X-linked Adrenoleukodystrophy

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Abstract

X-linked adrenoleukodystrophy (XALD) is a genetically determined disorder that mainly involves the adrenal cortex and white matter structures of the CNS. Inheritance is X-linked recessive. The disease has a wide phenotypic variability. The childhood cerebral form is the most frequent and accounts for about half of the cases. The second most common form is adrenomyeloneuropathy (AMN), which accounts for about a quarter to one-third of the patients. The less frequently occurring forms are the adolescent cerebral form, the adult cerebral form and the Addison-only form. In addition, there are asymptomatic cases and cases with unusual presentation. These different phenotypes may occur within one affected family.

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References

  • Antoku Y, Koike F, Ohtsuka Y, Sakai T, Tsukamoto K, Nagara H, Iwashita H, Goto I (1991) Adrenoleukodystrophy: a correlation between satuated very long-chain fatty acids in mononuclear cells and phenotype. Ann Neurol 30: 101–103

    Article  PubMed  CAS  Google Scholar 

  • Aubourg P, Sellier N, Chaussain JL, Kalifa G (1989) MRI detects cerebral involvement in neurologically asymptomatic patients with adrenoleukodystrophy. Neurology 39: 1619–1621

    Article  PubMed  CAS  Google Scholar 

  • Aubourg P, Blanche S, Jambaqué I, Rocchiccioli F, Kalifa G, Naud-Saudreau C, Rolland MO, Debré M, Chaussain JL

    Google Scholar 

  • Griscelli C, Fischer A, Bougnères PF (1990) Reversal of early neurologic and neuroradiologic manifestations of X-linked adrenoleukodystrophy by bone marrow transplantation. N Engl J Med 322: 1860–1866

    Article  PubMed  Google Scholar 

  • Aubourg P, Adamsbaum C, Lavallard-Rousseau MC, Lemaitre A, Boureau F, Mayer M, Kalifa G (1992) Brain MRI and electrophysiologic abnormalities in preclinical and clinical adrenomyeloneuropathy. Neurology 42: 85–91

    Article  PubMed  CAS  Google Scholar 

  • Bewermeijer H, Bamborschke S, Ebhardt G, Hunermann B, Heiss WD (1985) MR imaging in adrenoleukomyeloneuropathy. J Comput Assist Tomogr 9: 793–796

    Article  Google Scholar 

  • Blaw ME, Osterberg K, Kozak P, Nelson E (1964) Sudanophilic leukodystrophy and adrenal cortical atrophy. Arch Neurol 11: 626–631

    Article  PubMed  CAS  Google Scholar 

  • Boles DJ, Craft DA, Padgett DA, Loria RM, Rizzo WB (1991) Clinical variation in X-linked adrenoleukodystrophy: fatty acid and lipid metabolism in cultured fibroblasts. Biochem Med Metab Biol 45: 74–91

    Article  PubMed  CAS  Google Scholar 

  • Boutin B, Matsuguchi L, Lebon P, Ponsol G, Arthuis C (1989) Immunohistochemical analysis of brain macrophages in adrenoleukodystrophy. Neuropediatrics 20: 202–206

    Article  PubMed  CAS  Google Scholar 

  • Brown FR, Chen WW, Kirschner DA, Frayer KL, Powers JM, Moser AB, Moser HW (1983) Myelin membrane from adrenoleukodystrophy brain white matter -biochemical properties. J Neurochem 41: 341–348

    Article  PubMed  CAS  Google Scholar 

  • Coria F, Garcia-Viejo MA, Delgado JA, Duarte J, Claveria LE, Giros M, Pampols T (1993) Diagnosis of X-adrenoleucodystrophy phenotypic variants. Acta Neurol Scand 87: 499–502

    Article  PubMed  CAS  Google Scholar 

  • Davis LE, Snyder RD, Orth DN, Nicholson WE, Kornfeld M, Seelinger DF (1979) Adrenoleukodystrophy and adrenomyeloneuropathy associated with partial adrenal insufficiency in three generations of a kindred. Am J Med 66: 342347

    Google Scholar 

  • Demaerel P, Faubert C, Wilms G, Casaer P, Piepgras U, Baert AL (1991) MR findings in leukodystrophy. Neuroradiology 33: 368–371

    Article  PubMed  CAS  Google Scholar 

  • Domagk J, Linke I, Argyrakis A, Spaar FW, Rahlf G, Schulte FJ (1975) Adrenoleukodystrophy. Neuropediatrics 6: 41–64

    Article  Google Scholar 

  • Dumic M, Gubarev n, Sikic N, Roscher A, Playsic V, FilipovicGrcic B (1992) Sparse hair and multiple endocrine disorders in two women heterozygous for adrenoleukodystrophy. Am J Med Genet 43: 829–832

    Article  PubMed  CAS  Google Scholar 

  • Elrington GM, Bateman DE, Jeffrey MJ, Flawton N (1989) Adrenoleukodystrophy: heterogeneity in two brothers. J Neurol Neurosurg Psychiatry 52: 310–313

    Article  PubMed  CAS  Google Scholar 

  • Farrell DF, Hamilton SR, Knauss TA, Sanocki E, Deeb SS (1993) X-linked adrenoleukodystrophy:Adult cerebral variant. Neurology 43: 1518–1522

    Article  PubMed  CAS  Google Scholar 

  • Federico A, Dotti MT, Annunziata P, Bonuccelli U, Fenzi G, Ciacci G, Malandrini A, Meucci G, Guazzi GC (1988) Adrenomyeloneurodystrophy with late cerebral involvement and evidence of a multiple autoimmune disorder. J Inherited Metab Dis 11 Suppl 2: 169–172

    Article  Google Scholar 

  • Garg BP, Markand ON, DeMeyer WE, Warren C (1983) Evoked response studies in patients with adrenoleukodystrophy and heterozygous relatives. Arch Neurol 40: 356–359

    Article  PubMed  CAS  Google Scholar 

  • Graham GE, MacLeod PM, Lillicrap DP, Bridge PJ (1992) Gonadal mosaicism in a family with adrenoleukodystrophy:molecular diagnosis of carrier status among daughters of a gonadal mosaic when direct detection of the mutation is not possible. J Inherited Metab Dis 15: 68–74

    Article  PubMed  CAS  Google Scholar 

  • Hashimi M, Stanley W, Singh I (1986) Lignoceryol-CoASH ligase:enzyme defect in fatty acid 3-oxidation system in X-linked childhood adrenoleukodystrophy. FEBS Lett 196: 247–250

    Article  Google Scholar 

  • Higgens CB, Taketa RM, Halpern SE (1975) Abnormal brain scans in adrenal leukodystrophy. Radiology 114:667–669 Holmberg BH, Hägg E, Duchek M, Hagenfeldt L (1992) Screening of patients with hereditary spastic paraparesis and Addisons disease for adrenoleukodystrophy/adrenomyeloneuropathy. Acta Neurol Scand 85: 147–149

    Google Scholar 

  • Hong-Magno ET, Muraki AS, Huttenlocher PR (1987) Atypical CT scans in adrenoleukodystrophy. J Comput Assist Tomogr 11: 333–336

    Article  PubMed  CAS  Google Scholar 

  • Igarashi M, Belchis D, Suzuki K (1976a) Brain gangliosides in adrenoleukodystrophy. J Neurochem 27: 327–328

    Article  CAS  Google Scholar 

  • Igarashi M, Schaumburg HH, Powers J, Kishimoto Y, Kolodny E, Suzuki K (1976b) Fatty acid abnormality in adrenoleukodystrophy. J Neurochem 26: 851–860

    Article  PubMed  CAS  Google Scholar 

  • Igarashi M, Belchis D, Suzuki K (1976c) Brain gangliosides in adrenoleukodystrophy. J Neurochem 27: 327–328

    Article  CAS  Google Scholar 

  • Jensen ME, Sawyer RW, Braun IF, Rizzo WB (1990) MR imaging appearance of childhood adrenoleukodystrophy with auditory, visual, and motor pathway involvement. Radiographics 10: 53–66

    PubMed  CAS  Google Scholar 

  • Kaplan PW, Tusa RJ, Shankroff J, Heller J, Moser HW (1993) Visual evoked potentials in adrenoleukodystrophy:a trial with glycerol trioleate and Lorenzo oil. Ann Neurol 34: 169174

    Google Scholar 

  • Koike R, Tsuji S, Ohno T, Suzuki Y, Orii T, Miyatake T (1991) Physiological significance of fatty acid elongation system in adrenoleukodystrophy. J Neurol Sci 103: 188–194

    Article  PubMed  CAS  Google Scholar 

  • Kukowski B (1991) Magnetic transcranial brain stimulation and multimodality evoked potentials in an adrenoleukodystrophy patient and members of his family. Electroencephalogr Clin Neurophysiol 78: 260–262

    Article  PubMed  CAS  Google Scholar 

  • Kumar AJ, Rosenbaum AE, Naidu S, Wener L, Citrin CM, Lindenberg R, Kim WS, James Zinreich S, Molliver ME, Mayberg HS, Moser HW (1987) Adrenoleukodystrophy:Correlating MR imaging with CT. Radiology 165: 497–504

    PubMed  CAS  Google Scholar 

  • Kurihara M, Kumagai K, Yagishita S, Imai M, Watanabe M, Suzuki Y, Orii T (1993) Adrenoleukomyeloneuropathy presenting as cerebellar ataxia in a young child: a probable variant of adrenoleukodystrophy. Brain Dev 15: 377–380

    Article  PubMed  CAS  Google Scholar 

  • Kusaka H, Imai T (1992) Ataxic variant of adrenoleukodystrophy: MRI and CT findings. J Neurol 239: 307–310

    Google Scholar 

  • Lazo O, Contreras M, Hashmi M, Stanley W, Irazu C, Singh I (1988) Peroxisomal lignoceroyl-CoA ligase deficiency in childhood adrenoleukodystrophy and adrenomyeloneuropathy. Proc Natl Acad Sci U S A 85: 7647–7651

    Article  PubMed  CAS  Google Scholar 

  • Lenard HG (1984) Adrenoleukodystrophy. Neuropediatrics 15: 16–19

    Article  PubMed  Google Scholar 

  • Loes DJ, Hite S, Moser H, Stillman AE, Shapiro E, Lockman L, Latchaw RE, Krivit W (1994) Adrenoleukodystrophy: a scoring method for brain MR observations. AJNR 15: 1761–1766

    PubMed  CAS  Google Scholar 

  • Loes DJ, Stillman AE, Hite S, Shapiro E, Lockman L, Latchaw RE, Moser H, Krivit W (1994) Childhood cerebral form of adrenoleukodystrophy: short-term effect of bone marrow transplantation on brain MR observations. AJNR 15: 1767–1771

    PubMed  CAS  Google Scholar 

  • Lyon-Caen O, Benoit N, Carreau V, Montreuil M, Menage P, Lubetzki C, Cabanis E, Iba-Zizen MT, Tourbah A, Baumann N (1991) Cognitive function in adult adrenoleukodystrophy: comparison with leukoaraiosis and multiple sclerosis. Dev Neurosci 13: 251–253

    Article  PubMed  CAS  Google Scholar 

  • Maestri NE, Beaty TH (1992) Predictions of a 2-locus model for disease heterogeneity: application to adrenoleukodystrophy. Am J Med Genet 44: 576–582

    Article  PubMed  CAS  Google Scholar 

  • Marsh WW, Hurst DL (1991) Variable phenotypes in a family kindred with adrenoleukodystrophy. Pediatr Neurol 7: 50–52

    Article  PubMed  CAS  Google Scholar 

  • Martin JJ, Centerick C, Libert J (1980) Skin and conjunctival nerve biopsies in adrenoleukodystrophy and its variants. Ann Neurol 8: 291–295

    Article  PubMed  CAS  Google Scholar 

  • Molzer B, Bernheimer H, Budka H, Pilz P, Toifl K (1981) Accumulation of very long chain fatty acids is common to 3 variants of adrenoleukodystrophy ( ALD ). J Neurol Sci 51: 301–310

    Google Scholar 

  • Moser HW (1993) Lorenzo oil therapy for adrenoleukodystrophy: a prematurely amplified hope. Ann Neurol 34: 121–122

    Article  PubMed  CAS  Google Scholar 

  • Moser HW, Moser AB, Kawamura N, Murphy J, Suzuki K, Schaumburg H, Kishimoto Y (1980) Adrenoleukodystrophy: elevated C26 fatty acid in cultered skin fibroblasts. Ann Neurol 7: 542–549

    Article  PubMed  CAS  Google Scholar 

  • Moser HW, Moser AB, Frayer KK, Chen W, Schulman JD, ONeill BP, Kishimoto Y (1981) Adrenoleukodystrophy:increased plasma content of saturated very long chain fatty acids. Neurology 31: 1241–1249

    Article  PubMed  CAS  Google Scholar 

  • HW, Moser AE, Singh I, ONeill BP (1984) Adrenoleukodystrophy: survey of 303 cases: biochemistry, diagnosis, and therapy. Ann Neurol 16: 628–641

    Article  Google Scholar 

  • Moser HW, Bergin A, Naidu S, Ladenson PW (1991a) Adrenoleukodystrophy. Endocrinol Metab Clin North Am 20: 297–318

    PubMed  CAS  Google Scholar 

  • Moser HW, Moser AB, Naidu S, Bergin A (1991b) Clinical aspects of adrenoleukodystrophy and adrenomyeloneuropathy. Dev Neurosci 13: 254–261

    Article  PubMed  CAS  Google Scholar 

  • Moser HW, Moser AB, Smith KD, Bergin A, Borel J, Shankroff J, Stine OC, Merette C, Ott J, Krivit W, Shapiro E (1992) Adrenoleukodystrophy: phenotypic variability and implications for therapy. J Inherited Metab Dis 15: 645–664

    Article  PubMed  CAS  Google Scholar 

  • Mosser J, Douar AM, Sarde CO, Kioschis P, Feil R, Moser H, Poustka AM, Mandel JL, Aubourg P (1993) Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters. Nature 361: 726–730

    Article  PubMed  CAS  Google Scholar 

  • Nishio H, Kodama S, Tsubota T, Takumi T, Takahashi T, Yokoyama S, Matsuo T (1985) Adrenoleukodystrophy without adrenal insufficiency and its magnetic resonance imaging. J Neurol 232: 265–270

    Article  PubMed  CAS  Google Scholar 

  • Notarangelo LD, Parolini O, Baiguini G, Buzi F, Paterlini C, Perini A, Rimoldi M, Tiberti S, Uziel G, Notarangelo L, Camerino G, Ugazio AG (1992) Carrier detection in X-linked adrenoleukodystrophy by determination of very long chain fatty acid levels and by linkage analysis. Eur J Pediatr 151: 761–763

    Article  PubMed  CAS  Google Scholar 

  • ONeill BP, Forbes GS (1981) Computerized tomography and adrenoleukomyeloneuropathy. Arch Neurol 38: 293–296

    Article  CAS  Google Scholar 

  • ONeill BP, Marmion LC, Feringa ER (1981) The adrenoleukomyeloneuropathy complex: expression in four generations. Neurology 31: 151–156

    Article  CAS  Google Scholar 

  • ONeill BP, Moser HW, Saxena KM (1982) Familial X-linked Addison disease as an expression of adrenoleukodystrophy (ALD): elevated C26 fatty acid in cultured skin fibroblasts. Neurology 32: 543–547

    Article  CAS  Google Scholar 

  • Pasco A, Kalifa G, Sarrazin JL, Adamsbaum C, Aubourg P (1991) Contribution of MRI to the diagnosis of cerebral lesions of adrenoleukodystrophy. Pediatr Radiol 21: 161163

    Google Scholar 

  • Powell H, Tindall R, Schultz P, Paa D, OBrien J, Lampert P (1975) Adrenoleukodystrophy. Electron microscopic findings. Arch Neurol 32: 250–260

    Google Scholar 

  • Powers JM, Schaumburg HH (1974) Adreno-leukodystrophy (sex-linked Schilders disease). Am J Pathol 76: 481–491

    PubMed  CAS  Google Scholar 

  • Powers JM, Liu Y, Moser AB, Moser HW (1992) The inflammatroy myelinopathy of adreno-leukodystrophy: cells, effector molecules, and pathogenetic implications. J Neuropathol Exp Neurol 51: 630–643

    Article  PubMed  CAS  Google Scholar 

  • Ramsey RB, Banik NL, Scott T, Davison AN (1976) Neuro-chemical findings in adreno-leukodystrophy. J Neurol Sci 29: 277–294

    Article  PubMed  CAS  Google Scholar 

  • Rizzo WB (1993) Lorenzos oil–hope and disappointment. N Engl J Med 329: 801–802

    Article  PubMed  CAS  Google Scholar 

  • Rizzo WB, Leshner RT, Odone A, Dammann AL, Craft BS, Jensen ME, Jennings SS, Davis S, Jaitly R, Sgro JA (1989) Dietary erucic acid therapy for X-linked adrenoleukodystrophy. Neurology 39: 1415–1422

    Article  PubMed  CAS  Google Scholar 

  • Romero C, Dietemann JL, Kurtz D, Bataillard M, Christmann D (1990) Adrenoleucodystrophie: intéret de lIRM avec Gadolinium. J Neuroradiol 17: 267–276

    PubMed  CAS  Google Scholar 

  • Sack GH, Morrell JC (1993) Adrenoleukodystrophy: overlapping deletions point to a gene location in Xq28. Biochem Biophys Res Commun 191: 955–960

    Article  PubMed  CAS  Google Scholar 

  • Sadeghi-Nejad A, Senior B (1990) Adrenomyeloneuropathy presenting as addisons disease in childhood. N Engl J Med 322: 13–16

    Article  PubMed  CAS  Google Scholar 

  • Schaumburg HH, Powers JM, Raine CS, Suzuki K, Richardson EP (1975) Adrenoleukodystrophy: a clinical and pathological study of 17 cases. Arch Neurol 32: 577–591

    Article  PubMed  CAS  Google Scholar 

  • Schaumburg HH, Powers JM, Raine CS, Spencer PS, Griffin JW, Prineas JW, Boehme DM (1977) Adrenomyeloneuropathy: a probable variant of adrenoleukodystrophy. Neurology 27: 1114–1119

    Article  PubMed  CAS  Google Scholar 

  • Scholte W, Molzer B, Peiffer J, Poremba M, Schumm F, Harzer K, Schnabel R, Bernheimer H (1987) Adrenoleukodystrophy in an adult female. A clinical, morphological and neurochemical study. J Neurol 235: 1–9

    Google Scholar 

  • Sharp P, Johnson D, Poulos A (1991) Molecular species of phosphatidylcholine containing very long chain fatty acids in human brain:enrichment in X-linked adrenoleukodystrophy brain and diseases of peroxisome biogenesis brain. J Neurochem 56: 30–37

    Article  PubMed  CAS  Google Scholar 

  • Shimizu H, Moser HW, Naidu S (1988) Auditory brainstem response and audiologic findings in adrenoleukodystrophy: its variant and carrier. Otolaryngol Head Neck Surg 98: 215–220

    PubMed  CAS  Google Scholar 

  • Tanaka K, Koyama A, Koike R, Ohno T, Atsumi T, Miyatake T (1985) Adrenomyeloneuropathy:report of a family and electron microscopical findings in peripheral nerve. J Neurol 232: 73–78

    Article  PubMed  CAS  Google Scholar 

  • Theda C, Moser AB, Powers JM, Moser HW (1992) Phospholipids in X-linked adrenoleukodystrophy white matter: fatty acid abnormalities before the onset of demyelination. J Neurol Sci 110: 195–204

    Article  PubMed  CAS  Google Scholar 

  • Uchiyama M, Hata Y, Tada S (1991) MR imaging of adrenoleukodystrophy. Neuroradiology 33: 25–29

    Article  PubMed  CAS  Google Scholar 

  • Uyama E, Iwagoe H, Maeda J, Nakamura M, Terasaki T, Ando M (1993) Presenile-onset cerebral adrenoleukodystrophy presenting as Balints syndrome and dementia. Neurology 43: 1249–1251

    Article  PubMed  CAS  Google Scholar 

  • Uziel G, Bertini E, Bardelli P, Rimoldi M, Gambetti M (1991) Experience on therapy of adrenoleukodystrophy and adrenomyeloneuropathy. Dev Neurosci 13: 274–279

    Article  PubMed  CAS  Google Scholar 

  • Valle D, Gärtner J (1993) Penetrating the peroxisome. Nature 361: 682–683

    Article  PubMed  CAS  Google Scholar 

  • Van der Knaap MS, Valk J (1989) MR of adrenoleukodystrophy: histopathologic correlations. AJNR 10: S12 - S14

    PubMed  Google Scholar 

  • Van Geel BM, Assies J, Haverkort EB, Barth PG, Wanders RJA, Schutgens RBH, Keyser A, Zwetsloot CP (1993) Delay in diagnosis of X-linked adrenoleukodystrophy. Clin Neurol Neurosurg 95: 115–120

    Article  PubMed  Google Scholar 

  • Van Oost BA, van Zandvoort PM, Tünte W, Brunner HG, Hoogeboom AJM, Maaswinkel-Mooy PD, Bakkeren J, Hamel B, Ropers HH (1991) Linkiage analysis in X-linked adrenoleukodystrophy and application in post-and prenatal diagnosis. Hum Genet 86: 404–407

    Article  PubMed  Google Scholar 

  • Volkow ND, Patchell L, Kulkarni MV, Reed K (1987) Adrenoleukodystrophy: imaging with CT, MRI and PET. J Nucl Med 28: 524–527

    Google Scholar 

  • Wanders RJA, van Roermund CWT, van Wijland MJA, Heikoop J, van den Put A, Bentlage P, Meijboom E, Tager JM, Schram AW, van den Bosch H, Schutgens RBH (1987) Peroxisomal fatty acid 13-oxidation in human skin fibroblasts: X-linked adrenoleukodystrophy, a peroxisomal very long chain fatty acyl-CoA synthetase deficiency? J Inherited Metab Dis 10 Suppl 21: 220–224

    Article  Google Scholar 

  • Wanders RJA, van Roermund CWT, van Wijland MJA, Schutgens RBH, Schram AW, Tager JM, van den Bosch H, Schalkwijk C (1988) X-linked adrenoleukodystrophy: identification of the primary defect at the level of a deficient peroxisomal very long chain fatty acyl-CoA synthetase using a newly developed method for the isolation of peroxisomes from skin fibroblasts. J Inherited Metab Dis 11 Suppl 21: 173–177

    Article  Google Scholar 

  • Watkins PA, Naidu S, Moser HW (1987) Adrenoleukodystrophy: biochemical procedures in diagnosis, prevention and treatment. J Inherited Metab Dis 10: 46–53

    Article  PubMed  Google Scholar 

  • Weller M, Liedtke W, Petersen D, Opitz H, Poremba M (1992) Very-late-onset adrenoleukodystrophy:Possible precipitation of demyelination by cerebral contusion. Neurology 42L 367–370

    Article  PubMed  CAS  Google Scholar 

  • Willems PJ, Vits L, Wanders RJA, Coucke PJ, van der Auwera BJ, van Elsen AF, Raeymaekers P, van Broeckhoven C, Schutgens RBH, Dacremont G, Leroy JG, Martin JJ, Dumon JE (1990) Linkage of DNA markers at Xq28 to adrenoleukodystrophy and adrenomyeloneuropathy present within the same family. Arch Neurol 47: 665–669

    Article  PubMed  CAS  Google Scholar 

  • Wilson R, Sargent JR (1993) Lipid and fatty acid composition of brain tissue from adrenoleukodystrophy patients. J Neurochem 61: 290–297

    Article  PubMed  CAS  Google Scholar 

  • Wilson R, Tocher DR, Sargent JR (1992) Effects of exogenous monounsaturated fatty acids on fatty acid metabolism in cultured skin fibroblasts from adrenoleukodystrophy patients. J Neurol Sci 109: 207–214

    Article  PubMed  CAS  Google Scholar 

  • Zwetsloot CP, Padberg GW, van Seters AP, Maaswinkel-Mooy PD, Onkenhout W (1992) Adult adrenoleukodystrophy: the clinical spectrum in a large Dutch family. J Neurol 239: 107111

    Google Scholar 

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  1. Department of Child Neurology, Free University Hospital, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands

    Marjo S. van der Knaap MD, PhD

  2. Department of Diagnostic Radiology, Free University Hospital, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands

    Jacob Valk MD, PhD

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© 1995 Springer-Verlag Berlin Heidelberg

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van der Knaap, M.S., Valk, J. (1995). X-linked Adrenoleukodystrophy. In: Magnetic Resonance of Myelin, Myelination, and Myelin Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03078-3_19

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  • DOI: https://doi.org/10.1007/978-3-662-03078-3_19

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