The Small GTPase Rab4 Controls an Early Endocytic Sorting Event

  • Peter van der Sluijs
  • Michael Hull
  • Ira Mellman
Conference paper
Part of the NATO ASI Series book series (volume 74)


Small GTP binding proteins of the rab family have been implicated in the control of vesicular traffic in eukaryotes. It is thought that rab proteins ensure the specificity or directionality of a vesicle budding or fusion event by coupling the completion of the reaction to the hydrolysis of bound GTP (Bourne, 1988). Rab4 and rab5, two distinct rab proteins, have now been localized to early endosomes (Chavrier et al., 1990; van der Sluijs et al., 1991). Although the functions of the endosome-associated rabs are not clear, in vitro evidence indicates that rab5 is involved in lateral fusion between early endosomes (Gorvel et al., 1991). Although an activity for rab4 has yet to be established, it seems likely that it will play a role in the pathway of receptor recycling since it co-localizes with the transferrin receptor (Tfn-R) (van der Sluijs et al., 1991).


Transferrin Receptor Early Endosome Semliki Forest Virus Lateral Fusion Endocytic Compartment 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Peter van der Sluijs
    • 1
  • Michael Hull
    • 1
  • Ira Mellman
    • 1
  1. 1.Department of Cell BiologyYale University School of MedicineNew HavenUSA

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