Expression of Proto-Oncogenes and Protein Kinases in the Testis

  • Debra J. Wolgemuth
  • Jeremy Don
  • Deborah L. Chapman
  • Martin A. Winer
Part of the Schering Foundation Workshop book series (SCHERING FOUND, volume 4)


Specificity of expression is regarded as a strong indication that genes play a role in determining the phenotype or function of the cells in which they are expressed. A molecular genetic approach to understanding the control of male germ cell differentiation involves, in part, identifying genes that are expressed in a spermatogenic cell type-specific manner. Previous observations from our laboratory and others have shown that some testis-specific genes are expressed in spermatogenic cells in a stage-specific manner. Similarly, more ubiquitously expressed genes can exhibit particularly abundant expression in germ cells, often of uniquely sized transcripts. Both patterns of expression suggest a role for these genes in spermatogenesis or subsequent function of male gametes (rev. in Willison and Ashworth 1987; Hecht 1990; Erickson 1990; Wolgemuth and Watrin 1991).


Germ Cell Primordial Germ Cell Male Germ Cell Spermatogenic Cell Round Spermatid 
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© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Debra J. Wolgemuth
  • Jeremy Don
  • Deborah L. Chapman
  • Martin A. Winer

There are no affiliations available

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