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Expression of Proto-Oncogenes and Protein Kinases in the Testis

  • Debra J. Wolgemuth
  • Jeremy Don
  • Deborah L. Chapman
  • Martin A. Winer
Part of the Schering Foundation Workshop book series (SCHERING FOUND, volume 4)

Abstract

Specificity of expression is regarded as a strong indication that genes play a role in determining the phenotype or function of the cells in which they are expressed. A molecular genetic approach to understanding the control of male germ cell differentiation involves, in part, identifying genes that are expressed in a spermatogenic cell type-specific manner. Previous observations from our laboratory and others have shown that some testis-specific genes are expressed in spermatogenic cells in a stage-specific manner. Similarly, more ubiquitously expressed genes can exhibit particularly abundant expression in germ cells, often of uniquely sized transcripts. Both patterns of expression suggest a role for these genes in spermatogenesis or subsequent function of male gametes (rev. in Willison and Ashworth 1987; Hecht 1990; Erickson 1990; Wolgemuth and Watrin 1991).

Keywords

Germ Cell Primordial Germ Cell Male Germ Cell Spermatogenic Cell Round Spermatid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Debra J. Wolgemuth
  • Jeremy Don
  • Deborah L. Chapman
  • Martin A. Winer

There are no affiliations available

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