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Spermatogenesis — Fertilization — Contraception pp 201–224Cite as

Expression of Proto-Oncogenes and Protein Kinases in the Testis

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Part of the book series: Schering Foundation Workshop ((SCHERING FOUND,volume 4))

Abstract

Specificity of expression is regarded as a strong indication that genes play a role in determining the phenotype or function of the cells in which they are expressed. A molecular genetic approach to understanding the control of male germ cell differentiation involves, in part, identifying genes that are expressed in a spermatogenic cell type-specific manner. Previous observations from our laboratory and others have shown that some testis-specific genes are expressed in spermatogenic cells in a stage-specific manner. Similarly, more ubiquitously expressed genes can exhibit particularly abundant expression in germ cells, often of uniquely sized transcripts. Both patterns of expression suggest a role for these genes in spermatogenesis or subsequent function of male gametes (rev. in Willison and Ashworth 1987; Hecht 1990; Erickson 1990; Wolgemuth and Watrin 1991).

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Authors
  1. Debra J. Wolgemuth
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  2. Jeremy Don
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  3. Deborah L. Chapman
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  4. Martin A. Winer
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  1. Institute of Reproductive Medicine of the University, Steinfurter Str. 107, 4400, Münster, Germany

    Eberhard Nieschlag

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Wolgemuth, D.J., Don, J., Chapman, D.L., Winer, M.A. (1992). Expression of Proto-Oncogenes and Protein Kinases in the Testis. In: Nieschlag, E., Habenicht, UF. (eds) Spermatogenesis — Fertilization — Contraception. Schering Foundation Workshop, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02815-5_9

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