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The Ovarian and Testicular IGF-I System: A Comparative Analysis

  • Conference paper
Spermatogenesis — Fertilization — Contraception

Part of the book series: Schering Foundation Workshop ((SCHERING FOUND,volume 4))

Abstract

As the significance of putative intraovarian regulators becomes increasingly recognized, much of the attention centers on insulin-like growth factors (IGFs). Indeed, a large body of evidence now suggests the existence of an intraovarian IGF system complete with ligands, re-ceptors, and binding proteins (Adashi et al. 1985c). More importantly, IGFs have been shown to exert a variety of significant effects in murine (Adashi et al. 1985a,b,d; 1986b; Bicsak et al. 1986; Cara and Rosenfeld 1988; Davoren et al. 1985; Magoffin et al. 1990; Zhiwen et al. 1987), porcine (Baranao et al. 1984; Maruo et al. 1988; May et al. 1988; Veldhuis and Demers 1985; Veldhuis and Furlanetto 1985, Veldhuis et al. 1986a, b; Veldhuis et al. 1987; Veldhuis and Rodgers, 1987; Veldhuis and Gwynne 1989), and human (Erickson et al. 1989, 1990; Steinkampf et al. 1988) somatic ovarian cells, thereby raising the possibility of a meaningful in vivo role.

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Authors
  1. Eli Y. Adashi
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  2. Carol E. Resnick
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  3. Arye Hurwitz
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  4. Elisabetta Ricciarelli
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  5. Eleuterio R. Hernandez
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  6. Charles T. Roberts
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  7. Derek Leroith
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  8. Ron Rosenfeld
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Editors and Affiliations

  1. Institute of Reproductive Medicine of the University, Steinfurter Str. 107, 4400, Münster, Germany

    Eberhard Nieschlag

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© 1992 Springer-Verlag Berlin Heidelberg

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Adashi, E.Y. et al. (1992). The Ovarian and Testicular IGF-I System: A Comparative Analysis. In: Nieschlag, E., Habenicht, UF. (eds) Spermatogenesis — Fertilization — Contraception. Schering Foundation Workshop, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02815-5_7

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  • DOI: https://doi.org/10.1007/978-3-662-02815-5_7

  • Publisher Name: Springer, Berlin, Heidelberg

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