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Structure and Function of the Human Androgen Receptor

  • Albert O. Brinkmann
  • Guido Jenster
  • George G. J. M. Kuiper
  • Carrie Ris-Stalpers
  • Jacoba H. van Laar
  • Peter W. Faber
  • Jan Trapman
Conference paper
Part of the Schering Foundation Workshop book series (SCHERING FOUND, volume 4)

Abstract

Androgens play an essential role in several stages of male development [e.g. sexual differentiation, initiation and maintenance of spermatogenesis, development and maintenance of secondary male characteristics, feedback regulation of gonadotrophin secretion](Griffin and Wilson 1989). The action of androgenic hormones (e.g. testosterone and 5αdihydrotestosterone) is mediated by the intracellular androgen receptor, which belongs to a superfamily of ligand-dependent transcription factors. This family also includes the other steroid hormone receptors and the thyroid hormone and retinoic acid receptor subfamilies (Evans 1988; O’Malley 1990).

Keywords

Androgen Receptor Androgen Receptor Gene Androgen Receptor Protein Complete Androgen Insensitivity Syndrome Human Androgen Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Albert O. Brinkmann
  • Guido Jenster
  • George G. J. M. Kuiper
  • Carrie Ris-Stalpers
  • Jacoba H. van Laar
  • Peter W. Faber
  • Jan Trapman

There are no affiliations available

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