Regulation of Mammalian Fertilization by Gamete Adhesion Molecules

  • Paul M. Wassarman
Part of the Schering Foundation Workshop book series (SCHERING FOUND, volume 4)


Summarized here are certain aspects of research performed in this laboratory during the past twelve years or so. The focus is on the current status of our attempts to identify and characterize those molecules associated with the surface of mouse eggs and sperm that regulate species-specific gamete adhesion before and after fusion of gametes. We have made considerable headway with the egg surface (zona pellucida) components and, consequently, this aspect constitutes the bulk of the presentation. However, some attention is paid to sperm surface components involved in adhesion of sperm to eggs. It should be noted that there is evidence to suggest that conclusions drawn from our research on mice apply as well to many other mammals, including human beings.


Zona Pellucida Acrosome Reaction Cortical Granule Mouse Sperm Acrosomal Membrane 
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© Springer-Verlag Berlin Heidelberg 1992

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  • Paul M. Wassarman

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