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Magnetic Resonance Spectroscopy

  • Chapter
Inborn Metabolic Diseases

Summary

Information about intracellular metabolites and pH can be obtained directly and non-invasively from human tissues in vivo by using 31P magnetic resonance spectroscopy. These data can be used in the diagnosis of inherited metabolic conditions which result in abnormal cellular energetics. Defects in the glycogenolytic, glycolytic and oxidative phosphorylation pathways, and other types of disorders, lead to abnormalities identifiable in the magnetic resonance spectra. Because the overall response of the tissue to the basic biochemical abnormality is observed, magnetic resonance spectroscopy should prove to be particularly valuable in the identification and study of new and unusual disorders not easily diagnosed by other methods.

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Authors
  1. D. J. Taylor
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Editors and Affiliations

  1. Department of Pediatrics, University Hospital, Oostersingel 59, 9713 EZ, Groningen, The Netherlands

    John Fernandes M. D. (Professor of Pediatrics) (Professor of Pediatrics)

  2. Clinique de Génétique Médicale, Hôpital des Enfants Malades, 149, rue de Sèvres, 75743, Paris Cedex, France

    Jean-Marie Saudubray M. D. (Professor of Pediatrics) (Professor of Pediatrics)

  3. Department of Pediatrics, Tohoku University, School of Medicine, 1-1 Seiryo-machi, Sendai 980, Japan

    Keiya Tada M. D. (Professor of Pediatrics) (Professor of Pediatrics)

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© 1990 Springer-Verlag Berlin Heidelberg

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Taylor, D.J. (1990). Magnetic Resonance Spectroscopy. In: Fernandes, J., Saudubray, JM., Tada, K. (eds) Inborn Metabolic Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02613-7_6

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  • DOI: https://doi.org/10.1007/978-3-662-02613-7_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-02615-1

  • Online ISBN: 978-3-662-02613-7

  • eBook Packages: Springer Book Archive

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